Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.
Also Known As:
Class I Histocompatibility Antigens; Class I Human Antigens; Class I MHC Proteins; Class I Major Histocompatibility Antigens; Class I Major Histocompatibility Molecules; Human Class I Antigens; MHC Class I Molecules; MHC-I Molecules; MHC-I Peptides; Antigen, Class I; Antigens, Class I; I Antigen, Class; MHC I Molecules; MHC I Peptide; MHC I Peptides; Molecules, MHC-I; Peptide, MHC-I; Peptides, MHC-I; Class I Antigen; Class I Antigens; Class I Histocompatibility Antigen; Class I MHC Protein; Class I Major Histocompatibility Antigen; MHC Class I Molecule; MHC-I Peptide