Infratentorial Neoplasms (Posterior Fossa Tumors)

Intracranial tumors originating in the region of the brain inferior to the TENTORIUM CEREBELLI, which contains the cerebellum, FOURTH VENTRICLE; CEREBELLOPONTINE ANGLE; BRAIN STEM, and related structures. Primary tumors of this region are more frequent in children, and may present with ATAXIA; CRANIAL NERVE DISEASES; vomiting; HEADACHE; HYDROCEPHALUS; or other signs of neurologic dysfunction. Relatively frequent histologic subtypes include TERATOMA; MEDULLOBLASTOMA; GLIOBLASTOMA; ASTROCYTOMA; EPENDYMOMA; CRANIOPHARYNGIOMA; and choroid plexus papilloma (PAPILLOMA, CHOROID PLEXUS).

Also Known As:

Posterior Fossa Tumors; Benign Infratentorial Neoplasms; Infratentorial Cancer; Infratentorial Neoplasms, Benign; Infratentorial Neoplasms, Malignant; Malignant Infratentorial Neoplasms; Neoplasms, Infratentorial; Neoplasms, Posterior Fossa; Benign Infratentorial Neoplasm; Cancer, Infratentorial; Infratentorial Cancers; Infratentorial Neoplasm; Infratentorial Neoplasm, Benign; Infratentorial Neoplasm, Malignant; Infratentorial Tumor; Malignant Infratentorial Neoplasm; Neoplasm, Benign Infratentorial; Neoplasm, Infratentorial; Neoplasm, Malignant Infratentorial; Neoplasm, Posterior Fossa; Neoplasms, Malignant Infratentorial; Posterior Fossa Neoplasm; Posterior Fossa Tumor; Tumor, Infratentorial; Tumor, Posterior Fossa; Infratentorial Tumors; Posterior Fossa Neoplasms

Networked: 214 relevant articles (9 outcomes, 18 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Hydrocephalus (Hydrocephaly)
3.	Meningomyelocele (Myelomeningocele)
4.	Hypertension (High Blood Pressure)
5.	Wounds and Injuries (Trauma)

Experts

1.	Bouffet, Eric: 4 articles (06/2024 - 06/2011)
2.	Paganetti, Harald: 4 articles (01/2018 - 01/2017)
3.	Laughlin, Suzanne: 3 articles (06/2024 - 06/2011)
4.	Laprie, Anne: 3 articles (12/2023 - 01/2019)
5.	Tensaouti, Fatima: 3 articles (12/2023 - 01/2019)
6.	Biassoni, Veronica: 3 articles (01/2021 - 04/2009)
7.	Ferrari, Andrea: 3 articles (01/2021 - 04/2009)
8.	Massimino, Maura: 3 articles (01/2021 - 04/2009)
9.	Spreafico, Filippo: 3 articles (01/2021 - 04/2009)
10.	Terenziani, Monica: 3 articles (01/2021 - 04/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Infratentorial Neoplasms:

1.	Protons (Proton)IBA 01/01/2019 - "In the case of posterior fossa tumor, there was a lower dose to the brainstem with protons, in terms of V59 Gy, mean, and near-maximum (D2%) doses. " 01/01/2017 - "Proton Treatment Techniques for Posterior Fossa Tumors: Consequences for Linear Energy Transfer and Dose-Volume Parameters for the Brainstem and Organs at Risk." 01/01/2001 - "[Clinical application of proton magnetic resonance spectroscopy for differential diagnosis of pediatric posterior fossa tumors]." 01/01/2018 - "The 3 largest US pediatric proton therapy centers collectively summarized the incidence of symptomatic brainstem injury and physics details (planning, dosimetry, delivery) for 671 children with focal posterior fossa tumors treated with protons from 2006 to 2016. " 01/01/2001 - "Proton MRS of pediatric posterior fossa tumors seems to be helpful in prediction of tumor grading and histology. "
2.	Bromocriptine (Parlodel)FDA LinkGeneric 10/01/2021 - "Bromocriptine has shown to be an effective and safe treatment for CMS in pediatric patients after posterior fossa tumor resection."
3.	cytidylyl-(3'-5')-cytidine (CpC)IBA 01/01/2007 - "Endoscopic third ventriculostomy (ETV) alone or with choroid plexus cauterization (CPC) is an emerging and very useful technique to manage hydrocephalus specially in children with: ventriculitis as a consequence of meningitis, myelomeningocele, obstructive hydrocephalus idiopathic or seconday to posterior fossa tumors. "
4.	Fluorescein (Funduscein)FDA LinkGeneric 01/01/2023 - "This study aimed to verify the feasibility, safety, and benefit of using fluorescein sodium (FL) and a YELLOW 560 nm filter in posterior fossa tumors in children. " 01/01/2023 - "All cases of pediatric posterior fossa tumors that have undergone surgery using fluorescein (2018-2022) have been included and were examined retrospectively. " 01/01/2020 - "Using Fluorescein in the Resection of a Pediatric Posterior Fossa Tumor."
5.	Dexamethasone (Maxidex)FDA LinkGeneric 12/01/2017 - "Eligibility criteria for this biologic study included age 4-21 years, patients with CM undergoing craniectomy (as non-malignant surgical controls) and receiving dexamethasone for prevention of post-operative nausea, and those with newly diagnosed posterior fossa tumors (PFT) undergoing surgical resection and receiving dexamethasone as an anti-edema measure. "
6.	Biogenic Amines (Biogenic Amine)IBA 04/01/2014 - "The aim of the present study was to investigate the role of biogenic amines in the ventricular CSF of children suffering from posterior fossa tumors and their possible correlation with tumor histology and cognitive functioning. "
7.	SugammadexIBA 07/01/2015 - "The present comparative and randomized study investigated the use of sugammadex for reversing profound neuromuscular blockade (NMB) in pediatric neurosurgical patients undergone posterior fossa tumor excision. " 07/01/2015 - "Forty pediatric patients undergoing elective craniotomy for posterior fossa tumor excision were randomly divided into either of neostigmine or sugammadex group in which muscle relaxant was reversed at the end of anesthesia either with neostigmine 0.04 mg/kg added to atropine 0.02 mg/kg or sugammadex 4 mg/kg alone, respectively. "
8.	6-chloro-2-(1-piperazinyl)pyrazine (CPP)IBA 01/01/2024 - "CPP's should be included in the differential diagnosis of posterior fossa tumors, both in children and adults. " 09/01/2015 - "This report demonstrates that mild obstructive hydrocephalus due to a posterior fossa tumor may present with unexpected symptoms, such as CPP. " 05/01/2015 - "We herein report a sporadic case of posterior fossa tumor with synchronous choroid plexus papilloma (CPP) and ependymoma (EP) components. " 10/20/2021 - "A search was made in MEDLINE/Pubmed and MeSH Database using the terms "precocious puberty" AND "brain tumor" OR "posterior fossa tumor" OR "cerebellar tumor" OR "infratentorial tumor", identifying five cases of pediatric patients with infratentorial tumors and CPP and a case of cerebellar ganglioglioma without hypothalamic-pituitary-gonadal axis involvement and/or intracranial hypertension. "
9.	Carboplatin (JM8)FDA LinkGeneric 01/01/2021 - "Following surgery, patients with newly diagnosed high-risk/metastatic medulloblastoma received concurrent carboplatin (35 mg/m2 ) for 15 days (day 1 to day 15) during CSI plus posterior fossa/tumor bed boost, followed by six cycles of standard adjuvant chemotherapy. " 12/01/1997 - "We treated 25 children with nondisseminated medulloblastoma with complete or near complete surgical resection of the posterior fossa tumor, 3,600 cGy craniospinal irradiation (CSRT) and 5,400 cGy posterior fossa irradiation followed by adjuvant chemotherapy with carboplatin and vincristine. " 01/01/2021 - "All patients were in complete remission a median 65 months after treatment with craniospinal irradiation at 23.4 Gy, plus a boost on the posterior fossa/tumor bed up to 54 Gy, followed by cisplatin/carboplatin, lomustine, and vincristine for a maximum of eight courses. "
10.	Anesthetics (Anesthetic Agents)IBA 10/01/2016 - "Anesthetic Management of a Case of Posterior Fossa Tumor With An Intracardiac Mass." 08/01/1981 - "Perioperative anesthetic management of patients operated in sitting position for posterior fossa tumors." 09/01/1996 - "The authors compared anesthetic emergence from complex spinal surgery (spine; n = 47) with that from craniotomy for supratentorial nonfrontal (n = 22), frontal (n = 34), or posterior fossa tumor (n = 28). "

Therapies and Procedures

1.	Radiotherapy 08/01/2012 - "The primary aim of the present study was to establish the feasibility and safety of cardiorespiratory fitness testing in pediatric posterior fossa tumor survivors who had received cranial radiation therapy. " 01/01/2012 - "We summarize studies describing executive functioning deficits in pediatric posterior fossa tumor survivors who received cranial radiation therapy and intervention studies that have targeted executive functioning deficits. " 02/01/2024 - "This work explored the long-term impact of radiotherapy in children with posterior fossa tumor (PFT) on brain connectivity in neural circuits involved in memory using resting-state functional magnetic resonance imaging (rs-fMRI). " 01/01/2022 - "A review of long-term deficits in memory systems following radiotherapy for pediatric posterior fossa tumor." 01/01/2022 - "Treatment of malignant childhood posterior fossa tumors (CPFT) often includes surgical resection and craniospinal radiotherapy (CSI). "
2.	Ventriculostomy 08/01/2003 - "We report an unsuccessful trial of third ventriculostomy in a case with huge posterior fossa tumor." 01/01/2024 - "Considerations on very early management of endoscopic third ventriculostomy in children with posterior fossa tumors." 01/01/2023 - "We aim to find the temporal trend of incidence of post-resection cerebrospinal fluid (CSF) diversion (ventriculoperitoneal [VP] shunt/endoscopic third ventriculostomy [ETV]) in pediatric posterior fossa tumor (pPFT) patients with no pre-resection CSF diversion and the possible clinical predictors. " 02/21/2020 - "Does pre-resection endoscopic third ventriculostomy prevent the need for post-resection CSF diversion after pediatric posterior fossa tumor excision? " 01/01/2020 - "However, sometimes when the ventricular chambers distant from the site of pathology are tapped, there is a risk of neurological worsening due to paradoxical herniation of the brain, exemplified by the phenomenon of upward transtentorial herniation observed in posterior fossa tumors, consequent to a supratentorial ventriculostomy. "
3.	Drug Therapy (Chemotherapy) 12/01/2006 - "This study examined the effects of posterior fossa tumor surgery and concomitant irradiation and/or chemotherapy on the long-term recovery of balance function in children and adolescent patients. " 01/01/2021 - "Twenty-eight children with a history of posterior fossa tumor (17 treated with surgery, 11 treated with surgery and chemotherapy) underwent neuroimaging and neuropsychological assessment a mean of 4.5 years (surgery group) to 9 years (surgery + chemotherapy group) posttreatment, along with 18 healthy sibling controls. " 07/01/2020 - "Forty-four adults were considered (median follow-up 101 months): 36 had 23.4 Gy of CSI, and 8 had 30.6 Gy, plus a boost to the posterior fossa/tumor bed; 43 had chemotherapy as all 54 children, who had a median 83-month follow-up. " 04/01/2009 - "Seventeen patients were treated: previous treatment included CSI of 19.5-36 Gy with posterior fossa/tumor boost and chemotherapy in 16 patients. " 05/01/2008 - "The authors hypothesized that chemotherapy infusions directly into the fourth ventricle may potentially play a role in treating malignant posterior fossa tumors. "
4.	Therapeutics 01/01/2012 - "Improved medical therapies have increased survivorship rates for children with posterior fossa tumors; resultantly, morbidities associated with survivorship, such as executive function deficits, have become increasingly important to identify and address. " 09/01/2021 - "Quality of Life and Neurocognitive Functions of Children with Malignant Posterior Fossa Tumors after Adjuvant Therapy." 07/01/2015 - "Disease and therapy cause brain damage and subsequent functional loss in pediatric patients with posterior fossa tumors. " 04/01/2014 - "Diffusion tensor evaluation was performed in 14 children (median age, 4.1 years; age range, 1-20 years) who underwent serial MR imaging at 3T as part of routine follow-up after posterior fossa tumor resection with or without adjuvant therapy. " 12/01/2010 - "Gait analysis in children treated by surgery followed by adjuvant therapy for posterior fossa tumors."
5.	Operative Surgical Procedures 10/01/2002 - "Surgical procedures for posterior fossa tumors in children: does craniotomy lead to fewer complications than craniectomy?" 11/01/2013 - "Ommaya reservoir can produce good results through simple surgical procedures for treatment of acute hydrocephalus in children with posterior fossa tumors and is associated less trauma and complications." 01/01/2017 - "The incidence of a POH requiring a recraniotomy significantly correlated with the incidence of a hemangioblastoma, infratentorial tumors, and a prolonged operative time (>10 h), but not with the patient age or sex, surgical procedure (biopsy or craniotomy), surgical type (primary or secondary), bleeding volume, or intraoperative blood transfusion requirement. " 05/01/2009 - "The decline in IL-8 after RT was significant when stratified by infratentorial tumor location (p = 0.0345) and more than one surgical procedure (p = 0.0272). "