Spinal Tuberculosis (Pott's Disease)

06/12/2020 - "Allograft bone using titanium mesh in the posterior-only surgical treatment is effective for patients with thoracic and thoracolumbar spinal tuberculosis. "
01/01/2020 - "Both titanium mesh and bone grafts alone are effective for the treatment of thoracolumbar spinal tuberculosis based on safety. "
06/12/2020 - "We aimed to analyze the efficacy of bony fusion of allograft bone using titanium mesh in the posterior-only surgical treatment of thoracic and thoracolumbar spinal tuberculosis. "
06/12/2020 - "The efficacy of allograft bone using titanium mesh in the posterior-only surgical treatment of thoracic and thoracolumbar spinal tuberculosis."
01/01/2021 - "Objective: This study aimed to compare the effectiveness of titanium mesh cages (TMCs) with autogenous iliac bone grafts (AIBG) in posterior-only surgery for thoracic and lumbar spinal tuberculosis.Design"

12/01/2017 - "The aim of the present study was to compare the efficacy of the commercial Xpert Mycobacterium tuberculosis/rifampin (MTB/RIF) test for evaluating different types of spinal tuberculosis (TB) tissue specimens. "
01/01/2024 - "Proteomics study the potential targets for Rifampicin-resistant spinal tuberculosis."
02/01/2020 - "This study aims to determine the diagnostic accuracy, sensitivity, and specificity of the Xpert MTB/RIF assay (Mycobacterium Tuberculosis/Rifampicin resistance) for the detection of spinal Tuberculosis (TB) and rifampicin (RIF) resistance. "
01/01/2024 - "The findings suggest a promising avenue for the development of targeted drugs to enhance the management of Rifampicin-resistant spinal tuberculosis."
02/01/2020 - "Diagnostic Efficacy, Sensitivity, and Specificity of Xpert MTB/RIF Assay for Spinal Tuberculosis and Rifampicin Resistance."

02/01/2014 - "However, the pathogenesis of spinal tuberculosis has not been established because it was almost completely eradicated by the establishment of antibiotic treatment in the mid-20th century. "
03/01/2012 - "Magnetic Resonance Imaging has proven to be the best imaging modality to identify spinal TB while antibiotic treatment has made spinal tuberculosis a diagnostic problem instead of a therapeutic one. "
01/01/2011 - "Were selected, all folders with the probable diagnosis of spinal tuberculosis and whose antibiotic treatment was instituted. "
05/01/2011 - "Surgical treatment was previously the mainstay of therapy in cases of Pott's disease with neurological deficiency, but since clinical recovery was found in patients awaiting surgery, conservative management with antibiotic treatment as a first Line treatment has been advocated. "
01/01/2023 - "Lumbosacral tuberculosis, a rare manifestation of Pott's disease - How identified human skeletons from the pre-antibiotic era can be used as reference cases to establish a palaeopathological diagnosis of tuberculosis."

02/01/2010 - "To study the distribution of isoniazid and its metabolite in spinal tuberculosis following chemotherapy. "
04/04/2022 - "Here, we present an interesting case of new-onset delirium associated with isoniazid in an elderly female with spinal tuberculosis. "
04/04/2022 - "Case Report: Isoniazid-Associated Delirium in an Elderly Female with Spinal Tuberculosis."
04/11/2014 - "We report a case of pulmonary sarcoidosis, which occurred shortly after an isoniazid (INH)-resistant spinal tuberculosis was diagnosed which was suspected to be a miliary tuberculosis. "
03/01/2022 - "To evaluate the clinical efficacy of bovine serum albumin nanoparticles loaded with isoniazid and rifampicin (INH-RFP-BSA-NPs) in the treatment of spinal tuberculosis in rabbits. "

04/01/2009 - "Two cases were diagnosed as spinal tuberculosis after liver transplantation and were treated with socarboxazide, rifampicin, streptomycin and ethambutol for more than one year. "
05/01/2010 - "In conclusion, postoperative chemotherapy with the 9-month three-drug regimen of isoniazid, rifampicin, and ethambutol is effective when combined with surgical treatment of spinal tuberculosis using single-stage anterior autogenous bone grafting and instrumentation."
01/01/2023 - "Compared to the control tuberculosis group, the incidences of resistance to rifampicin (RFP) + isoniazid (INH) + streptomycin (STR) and INH + ethambutol (EMB) were lower in the spinal tuberculosis group, while the incidences of resistance to RFP + INH + EMB and RFP + EMB were higher. "
05/01/2015 - "The patient was preliminarily diagnosed with miliary tuberculosis (TB) and Pott's disease, and began administering anti-TB treatment consisting of isoniazid, rifampin, ethambutol, and pyrazinamide. "
04/01/1997 - "Patients with recent onset of spastic paraplegia due to clinically and radiologically active spinal tuberculosis involving vertebral bodies of level D4-L1 were treated with streptomycin, rifampicin, isoniazid and ethambutol daily for the first 2 months, followed by rifampicin plus isoniazid twice weekly for the next 7 months. "

06/01/2024 - "The objective of this study is to evaluate the value of S100-A8 protein as a diagnostic marker for spinal tuberculosis and to explore its role in the potential pathogenesis of spinal tuberculosis (STB). "
06/01/2024 - "S100-A8 protein has the value of diagnosing spinal tuberculosis (AUC = 0.931, p < 0.001), and the expression level in the peripheral blood of the observation group (59.04 ± 19.37 ng/mL) was significantly higher than that of the control group (43.16 ± 10.07 ng/mL) (p < 0.05). "
01/01/2022 - "The purpose of this article was to investigate the mechanism of immune dysregulation of COVID-19-related proteins in spinal tuberculosis (STB). "
01/01/2022 - "Mechanism of COVID-19-Related Proteins in Spinal Tuberculosis: Immune Dysregulation."
07/24/2020 - "Migration inhibitory factor in spinal tuberculosis: -173G/C polymorphisms, and transcript and protein levels in a northern province of China."

08/10/2023 - "No definitive reports of local streptomycin irrigation of the lesion and SSI of spinal tuberculosis have been seen. "
10/29/1983 - "Spinal tuberculosis: remember streptomycin."
08/10/2023 - "Topical streptomycin irrigation of lesions to prevent postoperative site infections in spinal tuberculosis: a retrospective analysis."
09/01/1954 - "[Associated Pott's disease and renal tuberculosis; present state of the problem, since the advent of streptomycin therapy]."
11/01/1950 - "[Streptomycin therapy of cases of Pott's paraplegia and quadriplegia]."

09/01/2013 - "Evaluation of an enzyme-linked immunospot assay for the immunodiagnosis of atypical spinal tuberculosis (atypical clinical presentation/atypical radiographic presentation) in China."
09/01/2013 - "This study aimed to assess the performance of a laboratory-developed recombinant CFP-10/ESAT-6 fusion protein (rCFP-10/ESAT-6)-based enzyme-linked immunospot (ELISPOT) assay for the diagnosis of spinal tuberculosis (TB) in China, and to evaluate the value of the ELISPOT assay for monitoring the efficacy of surgical treatment. "
01/01/1993 - "An enzyme immunoassay detected antituberculous antibodies in cerebrospinal fluid of 70% seropositive sufferers with spinal tuberculosis. "
09/01/2013 - "Enzyme-linked immunospot assay response to recombinant CFP-10/ESAT-6 fusion protein among patients with spinal tuberculosis: implications for diagnosis and monitoring of surgical therapy."
02/01/2015 - "To establish a method of detecting spinal tuberculosis (TB) infection by enzyme-linked immunospot (ELlSPOT) assay and evaluate the value of CFP10/ESAT6 fusion protein for diagnosis of spinal TB. "

09/01/2022 - "However, further studies are needed to evaluate better bedaquiline bone penetration and the correct duration of treatment with bedaquiline in MDR spinal tuberculosis."
09/01/2022 - "A salvage regimen containing bedaquiline proved effective in treating multidrug-resistance tuberculosis spinal infection without causing severe adverse effects. "

07/02/2019 - "CONCLUSIONS The rs1800871 (A/G) polymorphism in IL-10 gene is related to the susceptibility to spinal tuberculosis. "
07/02/2019 - "BACKGROUND To investigate the relation between interleukin-10 (IL-10) gene rs1800871 (A/G) polymorphism and spinal tuberculosis. "
07/02/2019 - "Relationship Between IL-10 Gene Polymorphism and Spinal Tuberculosis."
02/01/2015 - "To conclude, in patients of spinal tuberculosis, poor outcome is associated with higher pro-inflammatory serum TNF-α and IFN-γ, and CSF MMP-9 levels, and a lower anti-inflammatory serum IL-10 level."
01/01/2024 - "IL-10 and TGF-β1 may weaken the efficacy of preoperative anti-tuberculosis therapy in older patients with spinal tuberculosis."

01/01/2017 - "To use extreme lateral channel debridement and fusion combined with posterior fixation is an effective treatment for lumbar spinal tuberculosis. "
02/01/2008 - "The method of anterior radical debridement and interbody grafting with one-stage instrumentation anteriorly or posteriorly was effective for the treatment of thoracic and lumbar spinal tuberculosis."
12/02/2022 - "One-stage posterior instrumentation combined with anterior debridement and reconstruction using allogenic strut bone is a safe and effective procedure for children with multilevel lumbar spinal tuberculosis. "
11/25/2018 - "To explore the short-term efficacy of posterior percutaneous screw fixation combined with local percutaneous endoscopic debridement in treating senile spinal tuberculosis. "
12/01/2022 - "This study retrospectively analyzed 73 patients with thoracic and lumbar spinal tuberculosis who were treated using isolated posterior instrumentation without radical debridement in our hospital between January 2012 to December 2019. "

10/15/2005 - "The authors think that the single-stage anterior autogenous bone grafting and instrumentation are a safe and effective method in the surgical management of spinal tuberculosis."
06/01/2023 - "Structural bone grafting is considered the gold standard treatment for spinal tuberculosis bone defects; however, nonstructural bone grafting via the posterior approach has recently gained attention. "
02/01/1965 - "[OUR RESULTS ON RADICALLY-CURED POTT'S DISEASE WITH SURGERY (BONE TRANSPLANTATION)]."
06/01/2023 - "Studies comparing the clinical efficacy of structural and nonstructural bone grafting via the posterior approach in spinal tuberculosis surgery were identified from 8 databases from inception to August 2022. "
02/01/2002 - "To study the effect of anterior vertebrectomy, bone grafting and plating in the treatment of spinal tuberculosis. "

10/01/1977 - "The cornerstone to effective treatment for spinal tuberculosis is drug therapy and the anterior fusion operation. "
03/01/2010 - "After 4 to 6 weeks chemotherapy, the average ESR was (45.3 +/- 21.0) mm/h,and the average CRP was (26.7 +/- 11.8) mg/L, the differences were statistically (P < 0.05), and the clinical symptoms of spinal tuberculosis relieved in all patients. "
04/01/1997 - "To assess the efficacy of 9-month short-course chemotherapy (SCC) and to study the pattern of neurological recovery in patients with Pott's paraplegia. "
11/01/2012 - "Efficacy of extended DOTS category I chemotherapy in spinal tuberculosis based on MRI-based healed status."
10/01/2013 - "A systematic review and meta-analysis of randomized controlled trials (RCTs) studying the clinical benefit of chemotherapy with surgical intervention over chemotherapy alone for the treatment of spinal tuberculosis. "

08/01/2016 - "Our results show that one-stage posterior decompression, interbody grafts, and posterior instrumentation and fusion were an effective treatment for children with thoracolumbar spinal tuberculosis. "
03/01/2001 - "In the present study, it was concluded that the neurological involvement due to Pott's disease is relatively benign if urgent decompression is performed at the onset of the disease."
11/01/1965 - "[Contribution to the study of the problems of spinal cord decompression, of straightening and retention of the spine in late Pott's paraplegia due to a large hump back]."
03/01/2023 - "Biological Stabilisation vs Mechanical Fixation: Do We Always Require Instrumentation in Anterior Decompression Surgeries for Thoracolumbar Spinal Tuberculosis?"
05/01/2021 - "Spinal tuberculosis mainly involves anterior column and for that anterior approach has been the most frequently used surgical technique in the past as it allows direct access to the infected tissue providing a good decompression. "

01/01/2018 - "The perfect strategy for treating the thoracolumbar spinal tuberculosis has not yet been developed, and the personalized therapy for different patients warrants further study. "
03/01/2002 - "Despite the small number of studies, 6 months of therapy is probably sufficient for patients with spinal tuberculosis."
12/01/2023 - "The searches were performed using Medical Subject Headings terms, with "spinal tuberculosis," "diagnosis," "epidemiology," and "etiology","management," "surgery," and "therapy" as subheadings. "
09/12/2023 - "CONCLUSIONS For patients suffering from thoracolumbar spinal tuberculosis exhibiting progressive neurological deterioration, surgical intervention is deemed feasible after a brief period (usually 1-7 days) of intensive preoperative antitubercular therapy. "
01/13/2023 - "He was a known case of spinal tuberculosis and was on anti-tubercular therapy. "