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Thiazepines

Compounds that are derivatives of THIEPINS, with a nitrogen replacing a carbon in the seven-membered heterocyclic compound.

Also Known As:

Thiazepine

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiepins
    - Thiazepines: 6
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azepines: 11
    - Thiazepines: 6
  - Thiepins
    - Thiazepines: 6

Experts

1.	Eisenberg, Michael: 1 article (01/2022)
2.	Jensen, Tina Kold: 1 article (01/2022)
3.	Lindahl-Jacobsen, Rune: 1 article (01/2022)
4.	Lu, Ying: 1 article (01/2022)
5.	Skakkebæk, Niels Erik: 1 article (01/2022)
6.	Tian, Lu: 1 article (01/2022)
7.	Wensink, Maarten: 1 article (01/2022)
8.	Deng, Yu-Shan: 1 article (01/2021)
9.	Hasegawa, Shiori: 1 article (01/2021)
10.	Hashida, Tohru: 1 article (01/2021)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2016 - "Discovery of Novel Tricyclic Thiazepine Derivatives as Anti-Drug-Resistant Cancer Agents by Combining Diversity-Oriented Synthesis and Converging Screening Approach." 01/01/2021 - "In this work, a series of diaryl benzo[b][1,4]thiazepine derivatives D1-D36 were synthesized and screened as tubulin polymerization inhibitors with anti-tumor potency. " 03/17/2016 - "From fighting depression to conquering tumors: a novel tricyclic thiazepine compound as a tubulin polymerization inhibitor."
2.	Hyperphosphatemia 01/01/2021 - "The median number of days (interquartile range) until the onset of an adverse event caused by each drug category was as follows: barium sulfate containing X-ray contrast media [2.0 (1.0-3.0)], diazepines, oxazepines, thiazepines, and oxepines [8.0 (8.0-18.5)], drugs for treatment of hyperkalemia and hyperphosphatemia [29.0 (8.0-55.0)], non-selective monoamine reuptake inhibitors [19.0 (7.0-47.5)], and oral bowel cleanser [0.0 (0.0-0.0)]. "
3.	Myeloid Leukemia (Leukemia, Myelocytic) 11/11/2010 - "Thirteen tricyclic dibenzo-diazepine, -oxazepine, and -thiazepine analogues were studied and shown to induce variable degrees of histone H3/H4 and tubulin acetylation in a cellular model of myeloid leukemia sensitive to all-trans retinoic acid (ATRA). "
4.	Hyperkalemia 01/01/2021 - "The median number of days (interquartile range) until the onset of an adverse event caused by each drug category was as follows: barium sulfate containing X-ray contrast media [2.0 (1.0-3.0)], diazepines, oxazepines, thiazepines, and oxepines [8.0 (8.0-18.5)], drugs for treatment of hyperkalemia and hyperphosphatemia [29.0 (8.0-55.0)], non-selective monoamine reuptake inhibitors [19.0 (7.0-47.5)], and oral bowel cleanser [0.0 (0.0-0.0)]. "
5.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 03/17/2016 - "A novel tricyclic thiazepine derivative, 6-(p-tolyl)benzo[f] pyrido[2,3-b][1,4] thiazepine 11,11-dioxide (TBPT), exhibits potent inhibitory effects in two non-small-cell lung cancer cell lines, H460 and its drug-resistant variant, H460(TaxR), while exhibiting much less toxic effects on normal human fibroblasts. "

Related Drugs and Biologics

1.	Tubulin Modulators
2.	Oxazepines
3.	Tubulin
4.	Tretinoin (Retinoic Acid)
5.	Antipsychotic Agents (Antipsychotics)
6.	Histones (Histone)
7.	Contrast Media
8.	Barium Sulfate (Barite)