A progressive neurodegenerative condition of the central and autonomic nervous systems characterized by atrophy of the preganglionic lateral horn neurons of the thoracic spinal cord. This disease is generally considered a clinical variant of MULTIPLE SYSTEM ATROPHY. Affected individuals present in the fifth or sixth decade with ORTHOSTASIS and bladder dysfunction; and later develop FECAL INCONTINENCE; anhidrosis; ATAXIA; IMPOTENCE; and alterations of tone suggestive of basal ganglia dysfunction. (From Adams et al., Principles of Neurology, 6th ed, p536)
Also Known As:
Dysautonomia-Orthostatic Hypotension Syndrome; Syndrome, Dysautonomia-Orthostatic Hypotension; Autonomic Failures, Progressive; Dysautonomia Orthostatic Hypotension Syndrome; Dysautonomia-Orthostatic Hypotension Syndromes; Dysautonomic Orthostatic Hypotension; Dysautonomic Orthostatic Hypotensions; Failure, Progressive Autonomic; Failures, Progressive Autonomic; Hypotension Syndrome, Dysautonomia-Orthostatic; Hypotension Syndromes, Dysautonomia-Orthostatic; Hypotension, Dysautonomic Orthostatic; Hypotensions, Dysautonomic Orthostatic; Idiopathic Orthostatic Hypotension, Shy Drager Type; Orthostatic Hypotensions, Dysautonomic; Progressive Autonomic Failure; Progressive Autonomic Failures; Shy Drager Syndrome; Syndrome, Dysautonomia Orthostatic Hypotension; Syndrome, Shy-Drager; Syndromes, Dysautonomia-Orthostatic Hypotension; Autonomic Failure, Progressive; Idiopathic Orthostatic Hypotension, Shy-Drager Type; Orthostatic Hypotension, Dysautonomic