Secretory Component

The extracellular moiety of the POLYMERIC IMMUNOGLOBULIN RECEPTOR found alone or complexed with IGA or IGM, in a variety of external secretions (tears, bile, colostrum.) Secretory component is derived by proteolytic cleavage of the receptor during transcytosis. When immunoglobulins IgA and IgM are bound to the receptor, during their transcytosis secretory component becomes covalently attached to them generating SECRETORY IMMUNOGLOBULIN A or secretory IMMUNOGLOBULIN M.

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Networked: 316 relevant articles (2 outcomes, 33 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Pilette, C: 2 articles (12/2013 - 01/2001)
2.	Schneider, T: 2 articles (08/2009 - 05/2002)
3.	Zeitz, M: 2 articles (08/2009 - 05/2002)
4.	Smyrniotis, V: 2 articles (01/2003 - 01/2000)
5.	Bobos, M: 2 articles (01/2002 - 01/2002)
6.	Cheva, A: 2 articles (01/2002 - 01/2002)
7.	Jivannakis, T: 2 articles (01/2002 - 01/2002)
8.	Kotini, A: 2 articles (01/2002 - 01/2002)
9.	Lambropoulou, M: 2 articles (01/2002 - 01/2002)
10.	Papadopoulos, N: 2 articles (01/2002 - 01/2002)

Related Diseases

1.	Respiratory Tract Infections (Respiratory Tract Infection) 01/18/2012 - "Quality of child care is associated with a non-specific secretory component of children's mucosal immunity with well established protective effects against upper respiratory infections." 02/01/1999 - "Free secretory component as a standardization protein for nasopharyngeal specimens from children with upper respiratory tract infection." 01/01/1985 - "The concentrations of IgA and free secretory piece in the nasal secretions of patients with recurrent respiratory infections." 01/01/1985 - "The concentrations of total IgA, 11S IgA, total and free secretory piece (SP) were measured in the nasal secretions of 39 patients with recurrent upper and lower respiratory tract infections during an infection free period. " 09/01/1987 - "Correlation between the pharyngeal secretion of IgA, secretory-IgA and free secretory component and the upper respiratory tract infections in patients with IgA nephropathy."
2.	Immune Complex Diseases (Immune Complex Disease) 05/01/1989 - "However, the importance of biliary IgA antibodies is largely unclarified, and man lacks the capacity for effective clearance of IgA-antigen complexes via the secretory component-mediated transhepatocellular pathway; whether this deficit contributes to the propensity for man to develop IgA immune complex diseases should be clarified. "
3.	Neoplasms (Cancer) 10/15/1981 - "Immunofluorescent studies showed that secretory component (SC) was found to be diffusely distributed in cancer cells. " 01/01/2002 - "The results showed decreased expression of CD44 and increased expression of secretory component as the lesion progressed to malignancy." 09/01/1993 - "Nonspecific increased serum levels of secretory component in lung tumors: relationship to the gene expression of the transmembrane receptor form." 10/19/1990 - "Thus, the 26 kd integral transmembrane form of TNF may function in vivo to kill tumor cells and other targets locally in contrast to the systemic bioactivity of the secretory component." 05/01/1983 - "Secretory component levels in sera also revealed highly significant differences between cancer patients (1.65 +/- 0.73 micrograms/ml) and all control subjects (0.85 +/- 0.12 micrograms/ml, p less than 0.002). "
4.	Carcinoma (Carcinomatosis) 07/01/1989 - "Immunohistochemical study revealed secretory component (SC)-positive carcinoma cells in 12 cases (67%), most of which were also associated with squamous differentiation. " 11/23/2010 - "Oestrogen-progestrone-Her2neu receptor status was studied in various loci/foci of heterogeneous carcinoma of the breast and its metastatic secretory component in the lymph node in a lactating woman. " 12/01/1988 - "Lateral diffusion of the secretory component (SC) in the basolateral membrane of the human colon carcinoma cell line HT29 assessed with fluorescence recovery after photobleaching." 02/01/1976 - "Secretory component synthesis by carcinomas was associated with mucus production, although goblet cells did not contain SC. " 01/01/1976 - "Colon carcinoma, established in long-term tissue culture, has been shown to synthesize secretory component (SC). "
5.	Adenocarcinoma 12/01/1986 - "Secretory component was demonstrated in tumour cells in 25 (67%) adenocarcinomas. " 07/01/1978 - "A secretory component (SC) was detected by radioimmunoassay in the cyst fluids, ascitic fluids, and sera from patients with ovarian adenocarcinomas. " 07/01/1978 - "Quantitation of secretory component levels in cyst fluids, ascitic fluids, and sera from ovarian adenocarcinoma patients." 01/01/2002 - "In this study we examined CD44 and secretory component expression in adenomatous hyperplasia, atypical adenomatous hyperplasia and well-differentiated adenocarcinoma (cribriform pattern). " 11/01/1988 - "Metastatic adenocarcinomas of the lymph-node of pulmonary and colonic origin were positive for CEA and negative for lysozymes, and those from gastric, pancreatic, and gallbladder tumors were positive CEA and lysozymes, and those from gastric and pancreatic tumors were positive for the secretory component. "

Related Drugs and Biologics

1.	Immunoglobulin A (IgA)
2.	Antibodies
3.	Antigens
4.	Secretory Immunoglobulin A (SIgA)
5.	Keratins (Keratin)
6.	Carcinoembryonic Antigen
7.	Immunoglobulins (Immunoglobulin)
8.	Immunoglobulin M (IgM)
9.	Proteins (Proteins, Gene)
10.	Vimentin

Related Therapies and Procedures

1.	Prostheses and Implants (Prosthesis)
2.	Lung Transplantation
3.	Liver Transplantation
4.	Ligation
5.	Colectomy