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Prostaglandin Endoperoxides
Precursors in the biosynthesis of prostaglandins and thromboxanes from arachidonic acid. They are physiologically active compounds, having effect on vascular and airway smooth muscles, platelet aggregation, etc.
Also Known As:
Endoperoxides, Prostaglandin
Networked:
23
relevant articles (
1
outcomes,
4
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Inorganic Chemicals: 9
Electrolytes: 16106
Ions: 7857
Anions: 3501
Oxides: 2508
Peroxides: 1274
Prostaglandin Endoperoxides: 23
Prostaglandins G: 159
(+)-isomer 7-(3-((hexylthio)methyl)-7-oxabicyclo(2.2.1)hept-2-yl)-5-heptenoic acid
Prostaglandins H
SQ 28852
Free Radicals: 15039
Reactive Oxygen Species: 39360
Peroxides: 1274
Prostaglandin Endoperoxides: 23
Prostaglandins G: 159
(+)-isomer 7-(3-((hexylthio)methyl)-7-oxabicyclo(2.2.1)hept-2-yl)-5-heptenoic acid
Prostaglandins H
SQ 28852
Oxygen Compounds: 12
Oxides: 2508
Peroxides: 1274
Prostaglandin Endoperoxides: 23
Prostaglandins G: 159
(+)-isomer 7-(3-((hexylthio)methyl)-7-oxabicyclo(2.2.1)hept-2-yl)-5-heptenoic acid
Prostaglandins H
SQ 28852
Organic Chemicals: 133
Free Radicals: 15039
Reactive Oxygen Species: 39360
Peroxides: 1274
Prostaglandin Endoperoxides: 23
Prostaglandins G: 159
(+)-isomer 7-(3-((hexylthio)methyl)-7-oxabicyclo(2.2.1)hept-2-yl)-5-heptenoic acid
Prostaglandins H
SQ 28852
Lipids: 114793
Fatty Acids: 27405
Unsaturated Fatty Acids: 8236
Eicosanoids: 3262
Prostaglandins: 17100
Prostaglandin Endoperoxides: 23
Prostaglandins G: 159
(+)-isomer 7-(3-((hexylthio)methyl)-7-oxabicyclo(2.2.1)hept-2-yl)-5-heptenoic acid
Prostaglandins H
SQ 28852
Biological Factors: 2472
Inflammation Mediators: 1113
Autacoids: 276
Eicosanoids: 3262
Prostaglandins: 17100
Prostaglandin Endoperoxides: 23
Prostaglandins G: 159
(+)-isomer 7-(3-((hexylthio)methyl)-7-oxabicyclo(2.2.1)hept-2-yl)-5-heptenoic acid
Prostaglandins H
SQ 28852
Experts
1.
Chłopicki, S
: 1 article (01/2001)
2.
Gryglewski, R J
: 1 article (01/2001)
3.
Marcinkiewicz, E
: 1 article (01/2001)
4.
Uracz, W
: 1 article (01/2001)
Related Diseases
1.
Thrombosis (Thrombus)
11/01/1976 - "
We conclude that a balance between formation by arterial walls of PGX which prevents platelet aggregation and release by blood platelets of prostaglandin endoperoxides which induce aggregation is of the utmost importance for the control of thrombus formation in vessels.
"
11/01/1988 - "
These studies demonstrate that prostaglandin endoperoxides modulate the response to TXA2 synthase inhibition in vivo and identify a drug combination of potential therapeutic efficacy in the prevention of thrombosis.
"
07/01/1984 - "
These results indicate that thromboxane is not important in thrombus formation in the hamster, but that prostaglandin endoperoxides are more significant.
"
07/01/1984 - "
Prostaglandin endoperoxides and thromboxane A2 in thrombus formation in the hamster cheek pouch in vivo.
"
04/01/1977 - "
Collagen stimulates more platelet prostaglandin endoperoxides in thrombosis.
"
2.
Coronary Occlusion
02/01/1993 - "
The aim of this study was to assess whether prostaglandin endoperoxides, which continue to be formed in the setting of thromboxane A2 synthase inhibition, might influence the fate of ischemic myocardium in a model of coronary occlusion and reperfusion.
"
3.
Intracranial Vasospasm
12/01/1981 - "
The results of our previous experimental and clinical studies led us to the hypothesis that, in the pathogenesis of cerebral vasospasm, subarachnoid focal acidosis resulting from anaerobic changes of subarachnoid clots may be a factor upsetting the balanced synthesis of both thromboxane A2 and prostaglandin I2 from prostaglandin endoperoxides on the inner surface of cerebral arteries.
"
4.
Infarction (Infarctions)
02/01/1993 - "
Endogenous prostaglandin endoperoxides may alter infarct size in the presence of thromboxane synthase inhibition: studies in a rabbit model of coronary artery occlusion-reperfusion.
"
5.
Endometriosis
06/15/1981 - "
The present study measured peritoneal fluid levels of two of the stable products of prostaglandin endoperoxides (thromboxane B2 and 6-keto-prostaglandin F1 alpha) in patients with and without endometriosis.
"
Related Drugs and Biologics
1.
Drug Combinations
2.
Thromboxane A2 (A2, Thromboxane)
3.
Thromboxanes
4.
Epoprostenol (Prostacyclin)
5.
Thromboxane B2
6.
prostaglandin F1
7.
A-factor (Streptomyces)
8.
Prostaglandins
9.
Desoxycorticosterone Acetate (DOCA)
10.
Prostaglandin H2 (PGH(2))