Glycoconjugates

Carbohydrates covalently linked to a nonsugar moiety (lipids or proteins). The major glycoconjugates are glycoproteins, glycopeptides, peptidoglycans, glycolipids, and lipopolysaccharides. (From Biochemical Nomenclature and Related Documents, 2d ed; From Principles of Biochemistry, 2d ed)

Also Known As:

Networked: 1353 relevant articles (34 outcomes, 138 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kurup, Parameswara Achutha: 15 articles (06/2004 - 07/2002)
2.	Kurup, Ravi Kumar: 14 articles (12/2003 - 07/2002)
3.	Adamo, Roberto: 12 articles (10/2022 - 11/2013)
4.	Zwierz, Krzysztof: 11 articles (01/2014 - 07/2007)
5.	Berti, Francesco: 10 articles (04/2022 - 04/2008)
6.	Waszkiewicz, Napoleon: 9 articles (01/2014 - 01/2011)
7.	Pastuch-Gawołek, Gabriela: 8 articles (01/2022 - 11/2012)
8.	Seeberger, Peter H: 8 articles (11/2021 - 05/2005)
9.	Schumacher, Udo: 8 articles (04/2015 - 09/2005)
10.	Romano, Maria Rosaria: 7 articles (10/2022 - 11/2013)

Related Diseases

1.	Infections 07/17/2015 - "The two glycoconjugates were also effective in protecting newborn mice against GBS infection following vaccination of the dams. " 01/01/2019 - "Immunogenicity and protective efficacy against Salmonella C2-C3 infection in mice immunized with a glycoconjugate of S. " 10/05/2012 - "Overall, this study suggests that DMAG may be an active cell wall glycoconjugate driving host-pathogen interactions and participating in the immunopathogenesis of mycobacterial infections." 10/01/2023 - "These glycoconjugates are essential for the viability of Mtb and attribute to drug resistance and virulence during infection. " 01/01/2023 - "The present work describes a targeted and effective sensing and antibacterial platform based on glycoconjugates that have potential applications for the treatment of infections caused by pathogenic microorganisms."
2.	Neoplasms (Cancer) 08/02/2018 - "This work represents the first broad study of testing diverse heterogenous glycoconjugates (7 different glycoalbumins) for their differential in vivo binding (11 different cancer cell types) in both cell- and animal-based studies. " 10/14/2005 - "The capacity of EML to bind epithelial tumor cells makes it a potentially useful tool for study of some over-expressed GalNAc glycoconjugates." 05/01/1989 - "The purpose of this study is to investigate changes of glycoconjugates in the cancer cells of the urinary bladder by means of immunohistochemical methods. " 01/01/2023 - "Dysregulation of developmental and cell type-specific expression of glycoconjugates on hematopoietic cells: a new characteristic of myelodysplastic neoplasms (MDS)." 01/01/2021 - "Changes in glycosylation pattern of cell surface, body fluids and extracellular matrix glycoconjugates is a characteristic feature of tumor cell malignancy. "
3.	Bacterial Infections (Bacterial Infection) 12/17/2004 - "srf-3, a mutant of Caenorhabditis elegans, resistant to bacterial infection and to biofilm binding, is deficient in glycoconjugates." 11/20/2001 - "The mechanism by which defective CFTR (CF transmembrane conductance regulator) leads to undersialylation of plasma membrane glycoconjugates, which in turn promote lung pathology and colonization with Pseudomonas aeruginosa causing lethal bacterial infections in CF, is not known. " 08/18/2014 - "Design of multivalent glycoconjugates can find applications such as in anti-adhesive therapy against bacterial infections. " 06/01/2000 - "Because of the affinity of certain bacterial species for sulphated glycoconjugates exposed on the epithelial cells of susceptible hosts, we hypothesized that sulphated exopolysaccharides of microalgae can be used in anti-adhesive therapies against bacterial infections, both in cold- and warm-blooded animals. " 02/01/2008 - "Glycoconjugate vaccines have dramatically reduced the incidence of encapsulated bacterial diseases in toddlers under 2 years of age, but vaccine-induced antibody levels in this age group wane rapidly. "
4.	Meningococcal Infections 10/17/2005 - "Candidacy of LPS-based glycoconjugates to prevent invasive meningococcal disease: developmental chemistry and investigation of immunological responses following immunization of mice and rabbits." 10/01/2010 - "Investigating the candidacy of LPS-based glycoconjugates to prevent invasive meningococcal disease: immunology of glycoconjugates with high carbohydrate loading." 05/01/2010 - "Investigating the candidacy of LPS-based glycoconjugates to prevent invasive meningococcal disease: chemical strategies to prepare glycoconjugates with good carbohydrate loading." 12/01/2009 - "The development of quadrivalent glycoconjugate meningococcal ACWY vaccines has broadened protection against meningococcal disease. " 01/01/2021 - "Despite the considerable progress toward the eradication of meningococcal disease with the introduction of glycoconjugate vaccines, previously unremarkable serogroup X has emerged in recent years, recording several outbreaks throughout the African continent. "
5.	Carcinogenesis 10/01/2010 - "The present study thus suggests that TQ has potent chemopreventive efficacy as well as protected the abnormalities on cell surface glycoconjugates during DMBA induced hamster buccal pouch carcinogenesis." 01/01/2021 - "Aberrantly sialylated cellular glycoconjugates were found to be involved in different processes during tumorigenesis. " 01/01/2001 - "This altered expression of glycoconjugates revealed in the dysplastic epithelium indicates an aberrant glycosylation in the early premalignant stage of prostate carcinogenesis. " 06/01/1987 - "Cell surface glycoconjugates were investigated in a rat model of oral chemical carcinogenesis. " 02/01/2004 - "[Modification of glycoconjugates during the carcinogenesis: the case of mammary carcinomas]."

Related Drugs and Biologics

1.	Vaccines
2.	Polysaccharides (Glycans)
3.	Antibodies
4.	Proteins (Proteins, Gene)
5.	Immunoglobulin G (IgG)
6.	Glycoproteins (Glycoprotein)
7.	Sugars
8.	Glycolipids
9.	Glucose (Dextrose)
10.	9,10-Dimethyl-1,2-benzanthracene

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Drug Therapy (Chemotherapy)
4.	Immunomodulation
5.	Carbohydrate Loading Diet