Hidden Hearing Loss

Hearing loss that is difficult to diagnose by standard hearing tests as it most often pertains to difficulties in hearing only in certain situations such as in noisy environments.

Also Known As:

Hearing Loss, Hidden; Auditory Synaptopathies; Cochlear Synaptopathies; Cochlear Synaptopathy, Noise-Induced; Hidden Hearing Losses; Noise Induced Cochlear Synaptopathy; Noise-Induced Cochlear Synaptopathies; Synaptopathy, Auditory; Synaptopathy, Cochlear; Synaptopathy, Noise-Induced Cochlear; Auditory Synaptopathy; Cochlear Synaptopathy; Noise-Induced Cochlear Synaptopathy

Networked: 49 relevant articles (2 outcomes, 7 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Shock
2.	Hearing Loss (Hearing Impairment)
3.	Tinnitus
4.	Endolymphatic Hydrops
5.	Ototoxicity

Experts

1.	Moser, Tobias: 3 articles (01/2021 - 08/2013)
2.	Knipper, Marlies: 3 articles (10/2020 - 01/2019)
3.	Rüttiger, Lukas: 3 articles (10/2020 - 01/2019)
4.	Elgoyhen, Ana Belén: 2 articles (01/2022 - 01/2018)
5.	Ohlemiller, Kevin K: 2 articles (11/2021 - 01/2019)
6.	Applegate, Brian E: 2 articles (01/2021 - 01/2018)
7.	Oghalai, John S: 2 articles (01/2021 - 01/2018)
8.	Marchetta, Philine: 2 articles (10/2020 - 01/2020)
9.	Möhrle, Dorit: 2 articles (10/2020 - 01/2020)
10.	Schimmang, Thomas: 2 articles (10/2020 - 01/2019)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hidden Hearing Loss:

1.	Y 27632IBA 01/01/2021 - "Y-27632, a ROCK inhibitor, improved laser-induced shock wave (LISW)-induced cochlear synaptopathy in mice."
2.	Glutamic Acid (Glutamate)FDA Link 01/01/2022 - "Cochlear synaptopathy is a common cause of auditory disorders in which glutamate over-activation occurs. " 08/01/2013 - "Genetic auditory synaptopathies include alterations of glutamate loading of synaptic vesicles, synaptic Ca influx or synaptic vesicle turnover. " 03/01/2016 - "Human genetic and physiological studies, as well as research on animal models, have recently shown that disrupted IHC ribbon synapse function--resulting from genetic alterations that affect presynaptic glutamate loading of synaptic vesicles, Ca(2+) influx, or synaptic vesicle exocytosis--leads to hearing impairment termed 'auditory synaptopathy'. " 01/01/2018 - "Conversely, inducing endolymphatic hydrops in control mice by lowering perilymph osmolality caused cochlear synaptopathy that was glutamate-dependent, but did not cause hair cell loss. " 01/01/2021 - "We demonstrated that endolymphatic hydrops develops following blast injury, and that this phenomenon may be associated with glutamate excitotoxicity and cochlear synaptopathy. "
3.	Biomarkers (Surrogate Marker)IBA 12/13/2021 - "Speech-in-noise tests and suprathreshold auditory evoked potentials are promising biomarkers to diagnose cochlear synaptopathy (CS) in humans. " 12/13/2021 - "The Variability in Potential Biomarkers for Cochlear Synaptopathy After Recreational Noise Exposure." 11/28/2017 - "Collectively, the de novo ATP1A3 variant can cause postlingual-onset auditory synaptopathy, making this gene a significant contributor to sporadic progressive ANSD and a biomarker ensuring favorable short-term CI outcomes." 03/09/2018 - "The planned neuroimaging study aims to (1) identify central auditory biomarkers associated with hidden hearing loss; (2) investigate whether there are any additive contributions from tinnitus or diminished sound tolerance, which are often comorbid with hearing problems; and (3) explore the relation between subcortical functional magnetic resonance imaging (fMRI) measures and the auditory brainstem response (ABR). "
4.	Indicators and Reagents (Reagents)IBA 01/01/2020 - "The present study compared wave I amplitude of auditory brainstem responses (ABRs), a potential indicator of cochlear synaptopathy, among musicians and non-musicians with normal audiograms. " 01/01/2023 - "We also measured the rate of growth (slope) of auditory brainstem response wave-I amplitude with increasing level as an indirect indicator of cochlear synaptopathy, and the interference inhibition score in the Stroop color and word test (SCWT) as a proxy for inhibition. " 01/01/2020 - "Auditory Brainstem Response to Paired Click Stimulation as an Indicator of Peripheral Synaptic Health in Noise-Induced Cochlear Synaptopathy."
5.	1-dodecylpyridoxal (PLD)IBA 08/01/2022 - "The findings in this study suggest that the iPhone Health app may be a useful tool for further investigation into cochlear synaptopathy in PLD users." 08/01/2022 - "Little is known about objective classifying of noise exposure risk levels in personal listening device (PLD) users and electrophysiologic evidence of cochlear synaptopathy at very fast click rates. "
6.	phytobacteriomycin (PBM)IBA 11/01/2019 - "In this study, we assessed whether PBM could rescue cochlear synaptopathy after acoustic overexposure in rat. "
7.	lead acetateIBA 01/01/2022 - "Therefore, this study has evaluated cochlear synaptopathy and nitrative stress in young-adult mice exposed to 2 mM lead acetate for 28 days. "
8.	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/01/2022 - "These results suggest that magnetic targeting of AAV2(quad Y-F)-mediated BDNF gene therapy could reverse cochlear synaptopathy after NIHL." 10/06/2020 - "These results suggest that latency of auditory nerve processing, recruitment of hippocampal LTP, and Bdnf transcription, are key factors for age-dependent auditory processing deficits, rather than cochlear synaptopathy or aging per se." 10/06/2020 - "Using middle-aged and old BDNF-live-exon-visualization (BLEV) reporter mice we analyzed the specific recruitment of LTP and the activity-dependent usage of Bdnf exon-IV and -VI promoters relative to cochlear synaptopathy and central (temporal) processing. " 10/06/2020 - "Age-Dependent Auditory Processing Deficits after Cochlear Synaptopathy Depend on Auditory Nerve Latency and the Ability of the Brain to Recruit LTP/BDNF." 01/01/2019 - "BDNF, NT-3 and Trk receptor agonist monoclonal antibodies promote neuron survival, neurite extension, and synapse restoration in rat cochlea ex vivo models relevant for hidden hearing loss."
9.	Atrial Natriuretic Factor (ANF)IBA 01/01/2020 - "Our simulated performance following ANF loss is consistent with the hypothesis that cochlear synaptopathy impacts communication in background noise more so than in quiet. " 01/01/2016 - "Due to the functional importance of low-SR ANF units for temporal processing and signal coding in noisy backgrounds, deficits in cochlear coding associated with noise-induced damage may result in significant difficulties with temporal processing and hearing in noise (i.e., "hidden hearing loss"). "
10.	Cisplatin (Platino)FDA LinkGeneric 10/17/2023 - "The unfolded protein response (UPR) and endoplasmic reticulum (ER) stress pathways have been shown to be involved in the pathogenesis of noise-induced hearing loss and cochlear synaptopathy in vivo , and these pathways have been implicated broadly in cisplatin cytotoxicity. " 01/01/2019 - "Multiple doses of caffeine exacerbated cisplatin ototoxicity which was associated with damage to OHCs and cochlear synaptopathy. "

Therapies and Procedures

1.	Lasers (Laser) 01/01/2021 - "In this study, we aimed to validate the effect of ROCK inhibition on mice with cochlear synaptopathy induced by laser-induced shock wave (LISW) in vivo. " 01/01/2021 - "Y-27632, a ROCK inhibitor, improved laser-induced shock wave (LISW)-induced cochlear synaptopathy in mice."
2.	Therapeutics 01/01/2017 - "First, based on solid evidence of cochlear synaptopathy in animal models, it is time to apply molecular approaches to identify the underlying molecular mechanisms; improved understanding is necessary for developing rational, effective therapies against this cochlear synaptopathy. " 04/01/2021 - "These auditory synaptopathies and in general the cascades of hearing pathologies have been in the focus of research in recent years with the aim to develop more targeted and individually tailored therapeutics. " 11/01/2006 - "[Diagnosis and therapy of auditory synaptopathy/neuropathy]."
3.	Cochlear Implantation 01/01/2015 - "The individual outcome after cochlear implantation in children with auditory synaptopathy/neuropathy (AS/AN) is difficult to predict. " 08/01/2019 - "Auditory synaptopathy, auditory neuropathy, and cochlear implantation."
4.	Cochlear Implants (Cochlear Implant) 04/01/2021 - "Auditory synaptopathies also play an important role in cochlear implant (CI) care, as they can lead to a loss of physiological hearing in patients with residual hearing. " 01/01/2021 - "Clinical management of auditory synaptopathies like other genetic hearing disorders is currently limited to the use of hearing aids or cochlear implants. "
5.	Semiconductor Lasers 11/01/2019 - "Photobiomodulation using low-level 808 nm diode laser rescues cochlear synaptopathy after acoustic overexposure in rat."