Third Generation Cephalosporins

Agents that are structurally similar to other CEPHALOSPORINS but have a broader spectrum of activity against bacteria than the first and second generation cephalosporins. These agents cover more resistant STREPTOCOCCUS, STAPHYLOCOCCUS, gram-positive anaerobes, and more resistant strains of HAEMOPHILUS, NEISSERIA, PROTEUS, ESCHERICHIA COLI, and KLEBSIELLA (HNPEK).

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Networked: 1336 relevant articles (100 outcomes, 107 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hsueh, Po-Ren: 8 articles (01/2021 - 09/2004)
2.	Ko, Wen-Chien: 7 articles (01/2021 - 10/2006)
3.	Bonten, Marc J M: 6 articles (12/2021 - 01/2012)
4.	Tacconelli, Evelina: 6 articles (12/2021 - 08/2016)
5.	Aiken, Alexander M: 4 articles (01/2022 - 03/2021)
6.	Dramowski, Angela: 4 articles (01/2022 - 01/2020)
7.	de Kraker, Marlieke E A: 4 articles (01/2022 - 10/2011)
8.	Paterson, David L: 4 articles (04/2021 - 12/2002)
9.	Chiu, Cheng-Hsun: 4 articles (01/2021 - 04/2004)
10.	Lee, Ching-Chi: 4 articles (01/2021 - 01/2017)

Related Diseases

1.	Infections 02/01/1986 - "The new third generation cephalosporins have a significantly greater spectrum of action against gram-negative bacteria likely to be encountered in surgical infections. " 03/01/2012 - "Third-generation cephalosporins may be effective in empirically treating these patients, regardless of the acquisition site of the infection." 06/01/1984 - "As a class, the third generation cephalosporins are less active against gram-positive organisms, but in spite of this they have been clinically effective against infections due to S. " 05/29/2012 - "Studies performed in developed countries have shown that infections by third generation cephalosporin resistant Escherichia coli (G3CREC) are associated with increased mortality, but data from developing countries are scarce. " 10/01/2011 - "This study determined the excess number of deaths, bed-days, and hospital costs associated with blood stream infections (BSIs) caused by methicillin-resistant Staphylococcus aureus (MRSA) and third-generation cephalosporin-resistant Escherichia coli (G3CREC) in 31 countries that participated in the European Antimicrobial Resistance Surveillance System (EARSS). "
2.	Meningitis 12/16/1987 - "The prognosis of enterobacterial meningitis has improved with third generation cephalosporins. " 05/01/2022 - "A Rare Case of Third Generation Cephalosporin-Resistant Klebsiella Meningitis." 08/01/2019 - "Despite the use for 35 years of third-generation cephalosporins (3GCs), high morbidity and mortality rates with E. coli meningitis continue to occur. " 08/01/2018 - "Clinical characteristics of Citrobacter meningitis in adults: High incidence in patients with a postneurosurgical state and strains not susceptible to third-generation cephalosporins." 05/01/2014 - "coli isolates from cases of meningitis and less than 1% of isolates from UTI were resistant to third-generation cephalosporins. "
3.	Bacteremia 01/01/2021 - "This study aimed to investigate risk factors and clinical significance of third-generation cephalosporin nonsusceptibility (3GC-NS) among the cases of monomicrobial Enterobacteriaceae bacteremia (mEB) at regional or district hospitals. " 07/12/1993 - "The objective of this study was to determine whether the use of second- and third-generation cephalosporins is a risk factor for nosocomial enterococcal bacteremia (NEB), by means of a matched case-control study design. " 06/01/2021 - "In conclusion, TZP administration in cases of suspected Enterobacter spp. bacteremia previously treated with third-generation cephalosporin should be cautiously considered." 06/01/2021 - "Multivariate analysis revealed that the independent predictor associated with TZP-resistant Enterobacter spp. bacteremia was the previous usage of third-generation cephalosporins (P = 0.036). " 01/01/2021 - "Clinical Impact and Risk Factors of Nonsusceptibility to Third-Generation Cephalosporins Among Hospitalized Adults with Monomicrobial Enterobacteriaceae Bacteremia in Southern Taiwan: A Multicenter Study."
4.	Otitis Media 01/01/1992 - "There is concern that third-generation cephalosporins may not be effective in the treatment of acute otitis media due to Streptococcus pneumoniae. " 01/01/1992 - "The results of this in vivo animal study fail to support the contention that the two third-generation cephalosporins investigated are not effective in the treatment of pneumococcal acute otitis media. " 03/01/2014 - "Third-generation cephalosporin use for otitis media increased 1.6-, 15-, and 5.5-fold in plans A, B, and C in young children. " 01/01/1992 - "Third-generation cephalosporins in the treatment of acute pneumococcal otitis media. " 01/01/1998 - "Comparison of amoxicillin with second and third generation cephalosporins in the treatment of acute otitis media."
5.	Sepsis (Septicemia) 03/01/1983 - "The third-generation cephalosporins offer considerable promise in the empiric treatment of septicemia in children." 01/01/2023 - "This study aimed to quantify the impact of third-generation cephalosporin resistant (3GC-R) bloodstream infection (BSI) on economic and health related quality of life outcomes for adult patients in Blantyre, Malawi. " 01/01/2020 - "The aim of the study was to molecularly characterize third-generation cephalosporin-resistant Klebsiella pneumoniae isolated from bloodstream infections in Denmark in 2018 using whole-genome sequencing (WGS) data, and to compare these isolates to the most common clones detected in 2006 and 2008. " 08/01/2014 - "The aim of the study was to investigate the molecular epidemiology of 87 third-generation cephalosporin-resistant Escherichia coli (3GC-R Ec) from bloodstream infections in Denmark from 2009. " 10/01/2005 - "The aim of this study was to explore characteristics that are associated with bloodstream infections due to specific multiresistant microorganisms (methicillinresitant Staphylococcus aureus, MRSA; vancomycin-resistant enterococci, VRE; third-generation cephalosporin-resistant Enterobacteriaceae) or Candida spp. in hospitalized patients. "

Related Drugs and Biologics

1.	Anti-Bacterial Agents (Antibiotics)
2.	Ceftriaxone (Ceftriaxon)
3.	Penicillins (Penicillin)
4.	Fluoroquinolones
5.	Carbapenems (Carbapenem Antibiotics)
6.	Cefotaxime (Kendrick)
7.	Aminoglycosides
8.	Ceftazidime (Fortum)
9.	Ampicillin (Omnipen)
10.	beta-Lactamases (beta-Lactamase)

Related Therapies and Procedures

1.	Therapeutics
2.	Antibiotic Prophylaxis
3.	Length of Stay
4.	Aftercare (After-Treatment)
5.	Duration of Therapy