Ejaculatory Dysfunction

The inability in males to ejaculate, or to have a normal time to EJACULATION.

Also Known As:

Dysfunction, Ejaculation; Dysfunction, Ejaculatory; Dysfunctions, Ejaculation; Dysfunctions, Ejaculatory; Ejaculation Dysfunctions; Ejaculation, Delayed; Ejaculatory Dysfunctions; Ejaculatory Incompetences; Incompetence, Ejaculatory; Incompetences, Ejaculatory; Anejaculation; Delayed Ejaculation; Ejaculation Dysfunction; Ejaculatory Incompetence

Networked: 303 relevant articles (16 outcomes, 29 trials/studies)

Relationship Network

Disease Context: Research Results

Urogenital Diseases: 126
- Genital Diseases: 114
  - Physiological Sexual Dysfunction: 22
    - Ejaculatory Dysfunction: 303
      - Premature Ejaculation: 792
      - Retrograde Ejaculation: 276
  - Male Genital Diseases: 2
    - Ejaculatory Dysfunction: 303
      - Premature Ejaculation: 792
      - Retrograde Ejaculation: 276
- Male Urogenital Diseases
  - Male Genital Diseases: 2
    - Ejaculatory Dysfunction: 303
      - Premature Ejaculation: 792
      - Retrograde Ejaculation: 276

Related Diseases

1.	Premature Ejaculation
2.	Ejaculatory Dysfunction
3.	Lower Urinary Tract Symptoms
4.	Spinal Cord Injuries (Spinal Cord Injury)
5.	Hypertension (High Blood Pressure)

Experts

1.	Waldinger, Marcel D: 7 articles (04/2015 - 03/2002)
2.	Mulhall, John P: 5 articles (11/2021 - 09/2007)
3.	Maggi, Mario: 5 articles (06/2021 - 12/2005)
4.	Olivier, Berend: 5 articles (01/2007 - 03/2002)
5.	Borofsky, Michael: 4 articles (01/2022 - 01/2019)
6.	Dahm, Philipp: 4 articles (01/2022 - 01/2019)
7.	Abdel-Hamid, Ibrahim A: 4 articles (07/2021 - 01/2004)
8.	Hao, Zongyao: 4 articles (02/2014 - 06/2013)
9.	Liang, Chaozhao: 4 articles (02/2014 - 06/2013)
10.	Zhang, Xiansheng: 4 articles (02/2014 - 06/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ejaculatory Dysfunction:

1.	silodosin FDA Link 11/01/2015 - "Silodosin confirms to be highly effective in patients with LUTS/BPH; of them, almost 70% report either anejaculation or hypospermia, with a concomitant OF impairment in 17% of the patients. " 01/01/2020 - "Despite several male patients having dry orgasms due to Silodosin-induced anejaculation, the majority experienced improved erectile function. " 10/01/2008 - "Ejaculatory dysfunction caused by the new alpha1-blocker silodosin: A preliminary study to analyze human ejaculation using color Doppler ultrasonography." 07/01/2021 - "Silodosin, a highly selective alpha1A-blocker, which actually causes anejaculation, was effective treatment in 57% of the patients." 09/01/2017 - "Ejaculatory dysfunction that required discontinuation of silodosin medication developed in only one (2.5%) patient. "
2.	Testosterone (Sustanon)FDA Link 01/01/2017 - "Delayed Ejaculation and Associated Complaints: Relationship to Ejaculation Times and Serum Testosterone Levels. " 01/01/2017 - "Although delayed ejaculation (DE) is typically characterized as a persistently longer than anticipated or desired time to ejaculation (or orgasm) during sexual activity, a timing-based definition of DE and its association with serum testosterone has not been established in a large cohort. " 01/01/2017 - "Delayed Ejaculation and Associated Complaints: Relationship to Ejaculation Times and Serum Testosterone Levels." 01/01/2016 - "Effects of testosterone on primary outcomes were evaluated using the International Index of Erectile Function (IIEF) and the Men's Sexual Health Questionnaire, Ejaculatory Dysfunction, Short Form (MSHQ-EjD-SF) questionnaires. " 12/01/2015 - "Prevalence of the ejaculatory dysfunctions was substantial across a range of age, race, BMI, and serum testosterone categories. "
3.	Oxytocin (Pitocin)FDA LinkGeneric 01/01/2023 - "Findings from our studies suggest that the newly discovered "oxytocin-mediated spinal control of male sexual function" may be useful in the treatment of erectile and ejaculatory dysfunction." 01/01/2007 - "Oxytocin involvement in SSRI-induced delayed ejaculation: a review of animal studies." 01/01/2018 - "Various studies indicate that decreased oxytocin is involved as a mechanism of delayed ejaculation induced by SSRIs. " 01/01/2007 - "Preliminary data suggest that the severity of chronic SSRI treatment-induced delayed ejaculation and the differences between the various SSRIs in inducing ejaculation delay is related to gradual desensitization of 5-HT(1A) receptors on oxytocin neurons." 10/01/2020 - "Alternative Protocol Using Imipramine, Detomidine, and Oxytocin for Semen Collection in Stallion with Ejaculatory Dysfunction."
4.	Midodrine (Midon)FDA LinkGeneric 01/01/2015 - "In this small sample study, treatment of anejaculation after SCI with midodrine and PVS did not result in a better rate of antegrade ejaculation in 10 men than in 10 men treated with a placebo and PVS." 07/01/2014 - "Ejaculatory dysfunction is managed through penile vibratory stimulation and midodrine. " 07/01/2009 - "In patients with organic anejaculation but without SCI midodrine can reverse anejaculation in more than 50% of patients. " 12/01/2008 - "Penile vibratory stimulation (PVS) was performed in 158 SCI men on midodrine as part of a treatment for anejaculation, after they failed a baseline PVS. " 11/01/2007 - "The average dose of midodrine required for ejaculation was 18.7 mg. Midodrine is a safe and efficient adjunct to penile vibratory stimulation for anejaculation in spinal cord injured patients."
5.	Sildenafil Citrate (Viagra)FDA Link 09/01/2007 - "Thirty men with a score of <26 on the erectile function domain of the IIEF, or who complained of new onset rapid or delayed ejaculation, were treated with sildenafil with no randomization or placebo control. " 09/01/2007 - "In patients with ejaculatory dysfunction, the function improved in 64% after sildenafil therapy. " 12/01/1999 - "Oral sildenafil may reverse secondary ejaculatory dysfunction during infertility treatment."
6.	Tadalafil (Cialis)FDA Link 06/01/2018 - "Low dose daily versus on-demand high dose tadalafil in diabetic patients with erectile and ejaculatory dysfunction." 12/01/2012 - "Yangiing Capsule plus low-dose tadalafil is safe and effective for the treatment of functional anejaculation." 12/01/2012 - "[Yangjing capsule plus low-dose tadalafil for functional anejaculation]."
7.	anandamide (arachidonylethanolamide)IBA 05/01/2015 - "Sexual dysfunction: Anandamide shows promise for lifelong delayed ejaculation." 05/01/2015 - "Anandamide reduces the ejaculatory threshold of sexually sluggish male rats: possible relevance for human lifelong delayed ejaculation disorder."
8.	Sirtuin 3IBA 09/01/2013 - "We thereby hypothesize that modulation of the rhythmic contraction of the ejaculatory smooth muscles with either a Sirt3 activator or inhibitor may prove beneficial in treating either premature or delayed ejaculation. " 09/01/2013 - "Sirt3 modulation may be beneficial in the treatment of ejaculation dysfunction."
9.	Reserpine (Serpasil)FDA Link 10/01/2000 - "Treatment with reserpine resulted in gradual reduction in blood pressure and an improvement in ejaculatory dysfunction."
10.	Phenoxybenzamine FDA Link 01/01/1986 - "Phenoxybenzamine has been extremely effective in treating patients with vesical dysfunctions, its minimal side effects include anejaculation and delay and difficulty in ejaculation. "

Therapies and Procedures

1.	Transurethral Resection of Prostate (TURP) 06/01/2007 - "Predisposing factors of significant reduction of ejaculatory volume and anejaculation were age and TURP, although 51.6% of men already had EJD before TURP. " 01/01/2021 - "Ejaculatory dysfunction (eight studies, 461 participants): We are uncertain of the effects of PUL, PAE and TUMT on ejaculatory dysfunction compared to TURP (3 to 12 months; PUL: RR 0.05, 95 % CI 0.00 to 1.06; PAE: RR 0.35, 95% CI 0.13 to 0.92; TUMT: RR 0.34, 95% CI 0.17 to 0.68; low-certainty evidence). " 01/01/2021 - "However, TUMT may result in fewer cases of ejaculatory dysfunction compared to TURP (RR 0.36, 95% CI 0.24 to 0.53; 4 studies, 241 participants; low certainty). " 01/01/2022 - "TUMT provides a similar reduction in urinary symptoms compared to TURP, with fewer major adverse events and fewer cases of ejaculatory dysfunction at short-term follow-up. " 01/01/2022 - "However, TUMT may result in fewer cases of ejaculatory dysfunction compared to TURP. "
2.	Therapeutics 07/01/2009 - "Further studies are needed, however, for the evaluation of different treatment regimens in anejaculation therapy." 04/01/2020 - "We herein reported a case of wife-specific intercourse anejaculation succesfully treated with sexual therapy. " 01/01/2019 - "Each developed ejaculatory dysfunction during the treatment period, which resolved 1 year after completion of all therapies. " 08/01/2016 - "Psychosexual therapy for delayed ejaculation based on the Sexual Tipping Point model." 06/01/2015 - "These cases suggest that the use of color Doppler ultrasonography during ejaculation can improve the understanding of ejaculatory dysfunction and therapy for this condition. "
3.	Length of Stay 01/01/2022 - "RA-RPLND showed improved peri-operative outcomes compared to the matched cohort of O-RPLND-median blood loss (50 versus 400 ml, p < 0.00001), operative duration (150 versus 195 min, p = 0.023) length-of-stay (1 versus 5 days, p < 0.00001) and anejaculation (0 versus 4, p = 0.0249). " 01/01/2022 - "Post-chemotherapy RA-RPLND may have decreased blood loss, operative duration, hospital length-of-stay and anejaculation rates in selected cases and should, therefore, be considered in selected patients. " 04/01/2018 - "We assessed preoperative characteristics (age, testicular pathology, template, chemotherapy regimen, lesion size, and clinical stage), peroperative (operative time, estimated blood loss, intraoperative complication, node count, pathology, and number of positive node), and postoperative outcomes (postoperative complications, hospital length of stay, recurrence-free survival at 2 year, and ejaculation dysfunction). "
4.	Lymph Node Excision (Lymph Node Dissection) 02/01/1996 - "The risk of ejaculatory dysfunction from retroperitoneal lymph node dissection (RPLND) for low-stage disease has been nearly erased by nerve-sparing techniques. " 01/01/1993 - "Ejaculatory dysfunction after retroperitoneal lymphadenectomy." 05/01/1991 - "Electroejaculation is an excellent treatment for anejaculation that persists following retroperitoneal lymph node dissection." 05/01/1989 - "In an attempt to prevent ejaculatory dysfunction associated with retroperitoneal lymphadenectomy, the dissection has been modified to stay above the inferior mesenteric artery. " 03/01/1987 - "Electrostimulation via a rectal probe seems to be a useful technique for semen recovery in the patient with anejaculation after retroperitoneal lymph node dissection."
5.	Drug Therapy (Chemotherapy) 02/01/2014 - "Treatment of DE or anejaculation with pharmacotherapy has met with limited success. " 01/01/2022 - "Post-chemotherapy RA-RPLND may have decreased blood loss, operative duration, hospital length-of-stay and anejaculation rates in selected cases and should, therefore, be considered in selected patients. " 10/01/2012 - "Outcomes of the management of post-chemotherapy retroperitoneal lymph node dissection-associated anejaculation." 08/01/1997 - "Retroperitoneal lymph node dissection or resection of residual disease following chemotherapy are associated with a low mortality and morbidity rate, ejaculatory dysfunction excepted. " 01/01/1993 - "The incidence of ejaculatory dysfunction following retroperitoneal lymphadenectomy is therefore determined by the size and position of residual lymph node masses after chemotherapy and can be kept to a minimum by a careful nerve sparing operative technique."