Carbohydrate Sulfotransferases

Transmembrane enzymes of the Golgi network that recognize glycans attached to LIPIDS and PROTEINS passing through the secretory pathway.

Also Known As:

KSGal6ST; Carbohydrate Sulfotransferase 1; Carbohydrate Sulfotransferase 2; Carbohydrate Sulfotransferase 3; Carbohydrate Sulfotransferase 4; Carbohydrate Sulfotransferase 5; Carbohydrate Sulfotransferase 6; Carbohydrate Sulfotransferase 7; Chondroitin 6-Sulfotransferase; Corneal N-Acetylglucosamine 6-O-Sulfotransferase; GlcNAc-6-O-Sulfotransferase; Intestinal N-Acetylglucosamine 6-O-Sulfotransferase; Keratan Sulfate Gal-6 Sulfotransferase; Keratan Sulfate Gal-6-Sulfotransferase; Keratan Sulfotransferase; Keratan Sulfurtransferase

Networked: 34 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Wang, Na: 2 articles (09/2018 - 11/2013)
2.	Bonafé, Luisa: 2 articles (10/2010 - 06/2008)
3.	Reicherter, Kerstin: 2 articles (10/2010 - 06/2008)
4.	Rossi, Antonio: 2 articles (10/2010 - 06/2008)
5.	Spranger, Jürgen: 2 articles (10/2010 - 06/2008)
6.	Superti-Furga, Andrea: 2 articles (10/2010 - 06/2008)
7.	Unger, Sheila: 2 articles (10/2010 - 06/2008)
8.	Zabel, Bernhard: 2 articles (10/2010 - 06/2008)
9.	Akama, T O: 2 articles (05/2001 - 12/2000)
10.	Fukuda, M N: 2 articles (05/2001 - 12/2000)

Related Diseases

1.	Hereditary Corneal Dystrophies 11/01/2014 - "The aim of this study was to analyse corneal morphological organisation and identify mutations in the carbohydrate sulfotransferase 6 gene (CHST6) in patients with macular corneal dystrophy originating in a Polish population. " 06/01/2005 - "The aim of this study was to examine the carbohydrate sulfotransferase 6 (CHST6) gene for mutations in a sibship with both macular corneal dystrophy (MCD) types I and II. Clinically relevant laboratory investigation. " 07/11/2023 - "Macular corneal dystrophy (MCD) is a progressive, bilateral stromal dystrophic disease that arises from mutations in carbohydrate sulfotransferase 6 (CHST6). " 04/01/2021 - "Carbohydrate sulfotransferase 6 gene (CHST6); compound heterozygous mutations; Han Chinese family; macular corneal dystrophy (MCD)." 04/01/2021 - "Macular corneal dystrophy (MCD), a rare autosomal recessive disorder, is caused by pathogenic mutations in the carbohydrate sulfotransferase 6 gene (CHST6) and is characterized by bilateral progressive stromal clouding and vision loss. "
2.	Neoplasms (Cancer) 01/01/2020 - "Carbohydrate sulfotransferase 4 (CHST4) plays an important role in lymphocyte homing and is abnormally expressed in several cancer types; however, its precise function in tumor development and progression is unknown. " 01/01/2019 - "Carbohydrate Sulfotransferase 7 (CHST7), encoded by the X chromosome, is abnormally expressed during tumor development. " 09/01/2018 - "Carbohydrate sulfotransferases were found to play an important role in metastatic spread of tumor cells. " 10/15/2023 - "Carbohydrate sulfotransferases have been applied mainly in diagnostics of connective tissue disorders, cancer and inflammations. " 01/01/2020 - "Carbohydrate Sulfotransferase 4 Inhibits the Progression of Hepatitis B Virus-Related Hepatocellular Carcinoma and Is a Potential Prognostic Marker in Several Tumors."
3.	Inflammation (Inflammations) 10/15/2023 - "Carbohydrate sulfotransferases have been applied mainly in diagnostics of connective tissue disorders, cancer and inflammations. " 01/01/2001 - "Carbohydrate sulfotransferases: novel therapeutic targets for inflammation, viral infection and cancer." 12/31/2002 - "The Gal/GalNAc/GlcNAc-6-O-sulfotransferases (GSTs) are a recently discovered family of carbohydrate sulfotransferases that share significant sequence homology at the amino acid level and mediate a number of different biological processes such as leukocyte adhesion at sites of chronic inflammation. " 01/01/2018 - "We hypothesized that attenuation of the carbohydrate sulfotransferase 1 (CHST1) gene encoding keratan sulfate galactose 6-O-sulfotransferase, an enzyme likely required for 6'-sulfation of some of these putative Siglec-F glycan ligands, would result in decreased Siglec-F lung ligand levels and enhanced allergic eosinophilic airway inflammation. "
4.	Intervertebral Disc Degeneration 05/16/2021 - "To investigate the regulatory effect of carbohydrate sulfotransferase 3 (CHST3) in cartilage endplate-derived stem cells (CESCs) on the molecular mechanism of intervertebral disc degeneration after nucleus pulposus repair in rats. " 05/16/2021 - "Carbohydrate sulfotransferase 3 (CHST3) overexpression promotes cartilage endplate-derived stem cells (CESCs) to regulate molecular mechanisms related to repair of intervertebral disc degeneration by rat nucleus pulposus." 11/01/2013 - "Lumbar disc degeneration is linked to a carbohydrate sulfotransferase 3 variant."
5.	Vision Disorders (Hemeralopia) 01/01/2022 - "Macular corneal dystrophy (MCD) an autosomal recessive disorder leading to severe visual impairment is caused by mutations in the carbohydrate sulfotransferase 6 (CHST6) gene. " 08/01/2010 - "Macular corneal dystrophy (MCD; OMIM 217800) is a rare autosomal recessive inherited disorder caused by mutations in the carbohydrate sulfotransferase 6 (CHST6) and characterised by the presence of unsulfated keratan sulfate proteoglycans (KSPGs) forming abnormal deposits that eventually lead to visual impairment. "

Related Drugs and Biologics

1.	Chondroitin Sulfates (Chondroitin Sulfate)
2.	Keratan Sulfate
3.	Dermatan Sulfate
4.	Enzymes
5.	Sulfotransferases
6.	Proteoglycans (Proteoglycan)
7.	Glycosaminoglycans
8.	Sialic Acid Binding Immunoglobulin-like Lectins
9.	Transforming Growth Factor beta (TGF-beta)
10.	Polysaccharides (Glycans)