Collagen Type XVII

A 220 kDa non-fibrillar collagen and basement membrane component. It is involved in healing wounds of the EPITHELIUM, CORNEAL.

Also Known As:

180 kDa Bullous Pemphigoid Autoantigen; BP180 Antigen; BP180 Autoantigen; Bullous Pemphigoid Autoantigen, BP180; Collagen Alpha-1(XVII) Chain; Collagen XVII; Collagen, Type XVII, Alpha 1 Chain; Type XVII Collagen

Networked: 265 relevant articles (3 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Nishie, Wataru: 28 articles (12/2020 - 03/2007)
2.	Shimizu, Hiroshi: 28 articles (10/2020 - 03/2007)
3.	Ujiie, Hideyuki: 22 articles (03/2022 - 09/2009)
4.	Bruckner-Tuderman, Leena: 20 articles (01/2018 - 01/2002)
5.	Zillikens, Detlef: 18 articles (01/2021 - 01/2002)
6.	Natsuga, Ken: 17 articles (01/2019 - 01/2009)
7.	Iwata, Hiroaki: 16 articles (03/2022 - 04/2009)
8.	Sitaru, Cassian: 16 articles (01/2022 - 01/2002)
9.	Tasanen, Kaisa: 15 articles (01/2017 - 03/2003)
10.	Franzke, Claus-Werner: 13 articles (01/2019 - 04/2008)

Related Diseases

1.	Neoplasms (Cancer) 03/01/2015 - "Increased collagen XVII expression was associated with decreased disease-free and cancer-specific survival. " 11/01/2023 - "Expression of the gene for collagen XVII (COL17A1) in tumor tissue is positively or negatively associated with patient survival depending on cancer type. " 01/13/2020 - "These data suggest the Oct4-HK2 pathway regulated by collagen XVII plays an important role in metabolic reprogramming and maintenance of CSC-like features in lung CSCs, which may aid in the development of new strategies in cancer treatment." 01/01/2020 - "COL17A1 (collagen type XVII alpha 1 chain) is known to be upregulated and has a prognostic role in many malignancies, as well as contributing to cell proliferation, apoptosis, and invasion. " 01/01/2020 - "Lastly, we discuss the importance of targeting collagen XVII and its ectodomain shedding as a novel strategy to curb tumor growth and reduce metastatic potential."
2.	Bullous Pemphigoid (Pemphigoid) 02/01/2011 - "Type XVII collagen ELISA indices significantly decreased after bullous pemphigoid remission." 05/01/2012 - "In vitro studies on ectodomain shedding of type XVII collagen have also provided basic knowledge on the development of bullous pemphigoid. " 07/01/2011 - "In vitro studies on ectodomain shedding of type XVII collagen have also provided basic knowledge on the development of bullous pemphigoid. " 01/01/2018 - "The basement membrane zone consists of multiple components, including collagen XVII (COL17), which is the target of bullous pemphigoid. " 12/01/2017 - "Type XVII collagen (COL17) and the non-collagenous 16A (NC16A) domain is regarded as the major pathogenic domains for bullous pemphigoid (BP). "
3.	Glioma (Gliomas) 10/17/2017 - "Knocked down Collagen XVII expression in glioma cell lines resulted in decreased tumor invasiveness, along with significant reduction of MMP9 expression, while increased Collagen XVII expression promotes invasive activities of glioma cells and associated with GBM recurrences. "
4.	Junctional Epidermolysis Bullosa (Epidermolysis Bullosa Letalis) 01/01/2001 - "In this study we describe six Italian patients presenting an unusually mild variant of non-Herlitz junctional epidermolysis bullosa associated with a reduced expression of type XVII collagen. " 01/01/2023 - "Severe tracheal involvement in type XVII collagen junctional epidermolysis bullosa." 01/01/2022 - "Junctional epidermolysis bullosa (JEB) is a debilitating hereditary skin disorder caused by mutations in genes encoding laminin-332, type XVII collagen (C17), and integrin-α6β4, which maintain stability between the dermis and epidermis. " 01/01/2019 - "Here, we used keratinocytes from patients with junctional epidermolysis bullosa with late onset, which exclusively produce a collagen XVII mutant with the p.R1303Q mutation within its extracellular C-terminus. " 05/01/2012 - "Mutations in the type XVII collagen gene (COL17A1) result in the blistering disorder non-Herlitz junctional epidermolysis bullosa (JEB-nH). "
5.	Skin Diseases (Skin Disease) 12/01/2020 - "Collagen XVII Processing and Blistering Skin Diseases." 02/01/2000 - "Sera of 81 patients with a clinically active blistering skin disease were reacted with full-length collagen XVII, the authentic soluble ectodomain, and recombinant fragments. " 01/01/2019 - "Bullous pemphigoid (BP) is an autoimmune blistering skin disease characterized by an autoimmune response to type XVII collagen (BP180). " 02/01/2022 - "Collagen type XVII α1 (COL17A1) encodes a hemidesmosomal protein at the epidermal-dermal junction and its variants are implicated in blistering skin diseases. " 10/01/2012 - "Inherited mutations or auto-antibodies targeting collagen XVII cause blistering skin disease. "

Related Drugs and Biologics

1.	Autoantibodies
2.	Antigens
3.	Autoantigens
4.	Immunoglobulin A (IgA)
5.	Messenger RNA (mRNA)
6.	Proteins (Proteins, Gene)
7.	Immunoglobulin G (IgG)
8.	Antibodies
9.	Epitopes
10.	Kalinin