Eukaryotic Translation Initiation Factor 5A

A component of eukaryotic initiation factor 5A that is involved in the elongation, termination, and stimulation of peptide bond formation. This factor is essential for cell proliferation

Also Known As:

Networked: 57 relevant articles (2 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kaiser, Annette: 4 articles (05/2020 - 06/2012)
2.	Mueller, Ann-Kristin: 3 articles (05/2020 - 06/2012)
3.	Ito, Akihiro: 3 articles (01/2018 - 01/2016)
4.	Yoshida, Minoru: 3 articles (01/2018 - 01/2016)
5.	Hauber, Joachim: 3 articles (05/2014 - 01/2012)
6.	Chen, Wei-June: 2 articles (03/2021 - 09/2010)
7.	Nakata, Akiko: 2 articles (01/2018 - 01/2016)
8.	Krepstakies, Marcel: 2 articles (05/2014 - 06/2012)
9.	Dondero, Richard: 2 articles (07/2012 - 11/2008)
10.	Taylor, Catherine A: 2 articles (07/2012 - 02/2007)

Related Diseases

1.	Mitochondrial Diseases (Mitochondrial Disease) 07/01/2006 - "Moreover, our study shows that the improvement of glutamate dysregulation, mitochondrial dysfunction and protein synthesis by CR is, at least partially, due to the CR-mediated alteration of the oxidation or the expression of PKM2, ENO1, INSP1, ATP-F1B, PKG1, IMPCH, ATP-F1A MDH, PKG1 and 14-3-3 zeta protein, DLP1, ACO2, DLDH, NPH3, eIF-5A and UNP1. " 12/01/2023 - "After 6 months of continuous SHED injections, the liver proteomic pattern was reversed from senescent (∼30 months) to a youthful state (∼3 months), accompanied with upregulation of hepatocytes marker genes, anti-aging protein Klotho, a global improvement of liver functional pathways proteins, and a dramatic regulation of ribosomal and mitochondrial proteins, including upregulation of translation elongation and ribosome-sparing proteins Rpsa and Rplp0; elongation factors Eif4a1, Eef1b2, Eif5a; protein-folding chaperones Hsp90aa and Hspe1; ATP synthesis proteins Atp5b, Atp5o, Atp5j; and downregulation of most ribosomal proteins, suggesting that the proteome homeostasis destruction and mitochondria dysfunction in the aged mice liver might be relieved after SHED treatment. "
2.	Neoplasms (Cancer) 10/01/2020 - "Eukaryotic translation initiation factor 5A in the pathogenesis of cancers." 02/17/2010 - "Fr-6 also could decrease the production level of eukaryotic translation initiation factor 5A, which is a potential cancer intervention target. " 01/01/2001 - "Finally, we propose eIF-5A as an additional target of anti-cancer strategies." 01/01/1999 - "The data strongly suggest that the post-translational modifications of eIF-5A could be a suitable target for the potentiation of the activity of anti-cancer agents." 01/10/1996 - "Since eIF-5A is the only known cellular substrate for DHS and GC7 has been reported to block the proliferation of CHO cells, it has been suggested that DHS may be a novel target for anti-cancer therapy. "
3.	Disease Progression 01/01/2012 - "These findings suggest that pharmacological inhibition of eIF-5A may represent a novel concept to treat glioblastomas and may help to substantially improve the clinical course of this tumor entity."
4.	Glioblastoma (Glioblastoma Multiforme) 01/01/2012 - "Importantly, targeting eIF-5A and its hypusine modification with GC7, a specific DHS-inhibitor, showed a strong antiproliferative effect in glioblastoma cell lines in vitro, while normal human astrocytes were not affected. " 01/01/2012 - "These findings suggest that pharmacological inhibition of eIF-5A may represent a novel concept to treat glioblastomas and may help to substantially improve the clinical course of this tumor entity." 01/01/2012 - "Here we report that eIF-5A as well as the hypusine-forming enzymes deoxyhypusine synthase (DHS) and deoxyhypusine hydroxylase (DOHH) are highly overexpressed in glioblastoma patient samples. "
5.	T-Cell Leukemia (Leukemia, T Cell) 05/01/1997 - "Recent studies have suggested that eIF-5A may be the cellular target of the human immunodeficiency virus type 1 Rev and human T cell leukemia virus type 1 Rex proteins. " 05/25/1999 - "In particular, inhibition of eIF-5A blocked the nuclear export of NESs derived from the HIV-1 Rev and human T cell leukemia virus type I Rex trans-activators, whereas nucleocytoplasmic translocation of the protein kinase inhibitor-NES was unaffected. " 05/01/1995 - "Effects of translation initiation factor eIF-5A on the functioning of human T-cell leukemia virus type I Rex and human immunodeficiency virus Rev inhibited trans dominantly by a Rex mutant deficient in RNA binding." 05/25/1999 - "Our data confirm that CRM1/exportin 1 is a general export receptor for leucine-rich NESs and suggest that eIF-5A acts either upstream of CRM1/exportin 1 or forms a complex with the NES and CRM1/exportin 1 in the nucleocytoplasmic translocation of the HIV-1 Rev and human T cell leukemia virus type I Rex RNA export factors."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Mitochondrial Proteins (Mitochondrial Protein)
3.	Proteome
4.	Ribosomal Proteins (Ribosomal Protein)
5.	Adenosine Triphosphate (ATP)
6.	14-3-3 Proteins (14-3-3 Protein)
7.	Glutamic Acid (Glutamate)
8.	Enzymes
9.	hypusine
10.	RNA (Ribonucleic Acid)

Related Therapies and Procedures

1.	Injections
2.	Therapeutics
3.	Lasers (Laser)