Pleuromutilins

A tricyclic diterpene natural product isolated from Pleurotus mutilus (now referred to as Clitopilus scyphoides). Possesses modest antibacterial activity against primarily gram-positive bacterial organisms.

Also Known As:

Networked: 95 relevant articles (3 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Paukner, Susanne: 11 articles (01/2022 - 03/2012)
2.	Gelone, Steven P: 8 articles (01/2022 - 01/2019)
3.	Wicha, Wolfgang W: 8 articles (01/2021 - 01/2019)
4.	File, Thomas M: 6 articles (01/2022 - 11/2019)
5.	Goldberg, Lisa: 5 articles (01/2022 - 11/2019)
6.	Sader, Helio S: 4 articles (01/2019 - 03/2012)
7.	Jin, Zhen: 3 articles (01/2022 - 02/2020)
8.	Alexander, Elizabeth: 3 articles (01/2022 - 06/2020)
9.	Das, Anita F: 3 articles (01/2022 - 05/2021)
10.	Moran, Gregory J: 3 articles (01/2022 - 05/2021)

Related Diseases

1.	Bacterial Pneumonia 08/01/2020 - "Lefamulin is a novel systemic, semi-synthetic pleuromutilin class of antimicrobials that has been shown to be effective against common respiratory pathogens associated with community-acquired bacterial pneumonia (CABP). " 02/01/2021 - "Lefamulin is a novel oral and intravenous (IV) pleuromutilin developed as a twice-daily treatment for community-acquired bacterial pneumonia (CABP). " 02/01/2021 - "Lefamulin: A Novel Oral and Intravenous Pleuromutilin for the Treatment of Community-Acquired Bacterial Pneumonia." 01/01/2021 - "Lefamulin is a novel pleuromutilin recently approved by the FDA for the treatment of community-acquired bacterial pneumonia. " 01/01/2021 - "Lefamulin is a novel IV and oral pleuromutilin recently approved for the treatment of community-acquired bacterial pneumonia (CABP). "
2.	Infections 09/01/1979 - "[The efficacy of pleuromutilins on Aegyptianella pullorum infections in chickens (author's transl)]." 01/15/2019 - "Antibacterial activity evaluation of synthetic novel pleuromutilin derivatives in vitro and in experimental infection mice." 01/01/2017 - "The human consequences of infection with pleuromutilin-resistant MRSA CC398 or enterococci were assessed as low for the public in general but high for vulnerable groups such as hospitalized and immunocompromised persons. " 09/03/2020 - "The data obtained in the present study supports the use of pleuromutilins and macrolides for the control of infections caused by porcine mycoplasmas. " 11/17/2023 - "In comparison to pleuromutilin (1) and tiamulin (2), one of the conjugates exhibited an expanded spectrum of activity, including Gram-negative bacteria and fungi, making it a promising option for combating microbial infections."
3.	Pneumonia (Pneumonitis) 04/01/2020 - "Lefamulin is a novel antibiotic that belongs to the pleuromutilin class with excellent activity against all microorganisms, including atypical pathogens, that cause community-acquired pneumonia (CAP). " 12/04/2021 - "Lefamulin was the first systemic pleuromutilin antibiotic approved for intravenous and oral use in adults with community-acquired bacterial pneumonia based on two phase 3 trials (Lefamulin Evaluation Against Pneumonia [LEAP]-1 and LEAP-2). " 11/13/2019 - "Efficacy and Safety of Intravenous-to-oral Lefamulin, a Pleuromutilin Antibiotic, for the Treatment of Community-acquired Bacterial Pneumonia: The Phase III Lefamulin Evaluation Against Pneumonia (LEAP 1) Trial." 01/01/2020 - "Erratum to: Efficacy and Safety of Intravenous-to-oral Lefamulin, a Pleuromutilin Antibiotic, for the Treatment of Community-acquired Bacterial Pneumonia: The Phase III Lefamulin Evaluation Against Pneumonia (LEAP 1) Trial." 05/08/2021 - "Lefamulin, a first-in-class pleuromutilin antibiotic approved for intravenous and oral use in adults with community-acquired bacterial pneumonia (CABP), was noninferior to moxifloxacin in the Lefamulin Evaluation Against Pneumonia (LEAP) 1 intravenous-to-oral switch study and the LEAP 2 oral-only study. "
4.	Neoplasms (Cancer) 11/01/2020 - "A2780 cells were injected subcutaneously into mice to determine the effects of pleuromutilin on the growth of tumor xenografts. " 11/11/2021 - "In this study, the identification of a novel Pleuromutilin derivative (compound 38) is presented, capable of significantly increasing the cellular level of ROS and inducing melanoma cancer cell death via necroptosis. " 11/01/2020 - "This study aimed to investigate the effects of pleuromutilin on migration and proliferation of A2780 and Caov-3 human ovarian carcinoma cells and the growth of A2780 tumor xenografts in mice and the molecular mechanisms involved. " 01/21/2021 - "Reference: Bo Zhang, Xiaoli Ma, Yuan Li, Sijing Li, Jiumei Cheng: Pleuromutilin Inhibits Proliferation and Migration of A2780 and Caov-3 Ovarian Carcinoma Cells and Growth of Mouse A2780 Tumor Xenografts by Down-Regulation of pFAK2. " 01/21/2021 - "Retracted: Pleuromutilin Inhibits Proliferation and Migration of A2780 and Caov-3 Ovarian Carcinoma Cells and Growth of Mouse A2780 Tumor Xenografts by Down-Regulation of pFAK2."
5.	Dysentery 01/01/2018 - "Identification of a New Antimicrobial Resistance Gene Provides Fresh Insights Into Pleuromutilin Resistance in Brachyspira hyodysenteriae, Aetiological Agent of Swine Dysentery." 01/01/2015 - "Sequence types and pleuromutilin susceptibility of Brachyspira hyodysenteriae isolates from Italian pigs with swine dysentery: 2003-2012." 08/06/2014 - "Currently, the most common treatment for swine dysentery is the use of pleuromutilins and resistance to these drugs also is increasingly being reported. " 08/01/2014 - "The loss of pleuromutilins as effective tools to treat swine dysentery because of further increases in resistance or as a consequence of restrictions would present a considerable threat to pig health, welfare and productivity. " 06/01/2001 - "The pleuromutilins are the only antimicrobial agents with sufficient minimum inhibitory concentration (MIC) values left to treat swine dysentery in Sweden. "

Related Drugs and Biologics

1.	lefamulin
2.	Anti-Bacterial Agents (Antibiotics)
3.	tiamulin
4.	valnemulin
5.	Macrolides
6.	Streptogramin A
7.	Coagulase
8.	Moxifloxacin (Avelox)
9.	retapamulin
10.	Oxazolidinones (2 Oxazolidone)

Related Therapies and Procedures

1.	Therapeutics
2.	Intravenous Administration