Neuroserpin

01/01/2020 - "Postmortem studies confirmed the involvement of neuroserpin in Alzheimer's disease. "
11/01/2013 - "A series of Alzheimer's disease brain tissues were compared to age-matched control brains for their expression of neuroserpin, THRβ1 and HuD by western blotting. "
12/01/2000 - "Mutations in the Neuroserpin gene have been reported to cause familial presenile dementia. "
05/01/2015 - "Familial encephalopathy with neuroserpin inclusions bodies (FENIB) is a serpinopathy that induces a rare form of presenile dementia. "
09/29/2006 - "Neuroserpin binds Abeta and is a neuroprotective component of amyloid plaques in Alzheimer disease."

10/25/2007 - "Neuroserpin single nucleotide polymorphisms (SNPs) chosen through HapMap were genotyped in the study population and assessed for association with stroke. "
10/25/2007 - "Neuroserpin polymorphisms and stroke risk in a biracial population: the stroke prevention in young women study."
07/15/2000 - "In the present study neuroserpin expression and its potential therapeutic benefits were examined in a rat model of stroke. "
08/06/2002 - "Administration of neuroserpin after stroke is neuroprotective, seemingly because it blocks the extravascular effect of tPA, leading to subsequent decrease in stroke volume and widening of the therapeutic window for the thrombolytic effect of tPA."
01/01/2019 - "The characterization of neuroserpin expression during physiological human brain development is essential for forthcoming studies which will explore its involvement in pathological conditions, such as perinatal hypoxia-ischaemia and adult stroke in human."

10/25/2007 - "This study provides the first evidence that neuroserpin is associated with early-onset ischemic stroke among Caucasian women."
10/01/2017 - "Effects of neuroserpin on clinical outcomes and inflammatory markers in Chinese patients with acute ischemic stroke."
05/11/2011 - "Association between neuroserpin and molecular markers of brain damage in patients with acute ischemic stroke."
03/01/2011 - "In summary, high serum neuroserpin levels before intravenous tPA and neuroserpin levels decrease at 24 h after ischaemic stroke, independently of tPA treatment, are associated with good functional outcome. "
03/01/2011 - "Our aim was to investigate the association of neuroserpin levels in blood with functional outcome in patients with acute ischaemic stroke. "

01/01/2010 - "Finally we outline the varied paradigms that have been employed in the study of the serpinopathies, and in particular, a dementia caused by neuroserpin polymerization."
01/01/2021 - "G392E neuroserpin causing the dementia FENIB is secreted from cells but is not synaptotoxic."
04/24/2009 - "These data provide a molecular explanation for the inherent instability of neuroserpin and the effect of point mutations that underlie the dementia FENIB."
06/01/2008 - "The intracellular accumulation of polymeric neuroserpin explains the severity of the dementia FENIB."
01/01/2006 - "This condition is characterized by the intracellular polymerization and accumulation of mutated neuroserpin, leading to neuronal death and dementia."

01/01/2021 - "Mutations in serpini1 cause familial encephalopathy, a rare neurodegenerative disorder characterized with neuroserpin inclusion bodies. "
05/01/2015 - "Familial encephalopathy with neuroserpin inclusions bodies (FENIB) is a serpinopathy that induces a rare form of presenile dementia. "
09/01/2011 - "In summary, we report a case of neuroserpin encephalopathy associated with a novel PI12 mutation and complicated by coexistent multiple sclerosis."
03/01/2011 - "Point mutations in the neuroserpin gene cause the autosomal dominant dementia familial encephalopathy with neuroserpin inclusion bodies or FENIB. "
01/01/2011 - "These inclusions underlie the autosomal dominant dementia familial encephalopathy with neuroserpin inclusion bodies or FENIB. "