Nudix Hydrolases

A group of Mg2+/Mn2+-dependent mainly pyrophosphohydrolases that hydrolyzes structures of NUcleoside DIphosphate linked to another moiety X to nucleoside monophosphate and X-Phosphate. Nudix hydrolases share conserved Nudix box (GX5EX7REUXEEXGU) and degrade variety of substrates including oxidized nucleotides (e.g., MutT) and metabolic intermediates (e.g., THIAMINE PYROPHOSPHATASE). In humans, Nudix superfamily proteins such as MutT proteins participate in DNA damage repairs. Mutations on a nudix hydrolase (NUDT15) are associated with a PURINE-PYRIMIDINE METABOLISM, INBORN ERRORS disorder called THPM2, and mutations in nudix hydrolase (NUDT2) are associated with IDDPN, a developmental intellectual disorder.

Also Known As:

Networked: 42 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Cui, Jing: 3 articles (12/2015 - 12/2014)
2.	Jiang, Peng: 3 articles (12/2015 - 12/2014)
3.	Liu, Li Na: 3 articles (12/2015 - 12/2014)
4.	Liu, Ruo Dan: 3 articles (12/2015 - 12/2014)
5.	Long, Shao Rong: 3 articles (12/2015 - 12/2014)
6.	Wang, Zhong Quan: 3 articles (12/2015 - 12/2014)
7.	Afrin, Sadia: 2 articles (11/2022 - 11/2020)
8.	Chen, Liang: 2 articles (01/2021 - 01/2019)
9.	Chen, Zhaohui: 2 articles (01/2021 - 01/2019)
10.	Hou, Teng: 2 articles (01/2021 - 01/2019)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2019 - "Purpose: Nudix Hydrolase 21 (NUDT21) is a crucial mediator involved in alternative polyadenylation (APA), and this molecule has been reported to be a tumor suppressor in human cancers. " 01/01/2021 - "Nudix Hydrolase 21 (NUDT21), an alternative polyadenylation (APA)-regulatory protein, exhibits tumor-suppressive effects. " 01/01/2022 - "As a member of the Nudix hydrolase superfamily, Nudix (nucleoside diphosphate-linked moiety X)-type motif 1 (NUDT1) is closely related to the occurrence and development of cancer. " 01/01/2018 - "The ADP-ribose reactive NUDIX hydrolase isoforms can modulate HIF-1α in cancer cells." 11/16/2017 - "To elucidate interdependence among the NUDIX hydrolases, we pairwise deplete them generating an epistatic interaction map, evaluate cell cycle perturbations upon knockdown in normal and cancer cells, and analyse their protein and mRNA expression in normal and cancer tissues. "
2.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 11/01/2022 - "Nudix hydrolase 15 (NUDT15) loss-of-function variants in an Australian inflammatory bowel disease population." 06/22/2023 - "Nudix hydrolase 15 (NUDT15) genetic variants confer an increased risk of thiopurine-induced leukopenia (TIL), however their global prevalence in Inflammatory Bowel Disease (IBD) patients is unknown. " 12/01/2020 - "Recent studies reported that Nudix Hydrolase 15(NUDT 15) gene variant (C415T) can better predict thiopurine induced leucopenia in Asian patients with inflammatory bowel disease (IBD) than thiopurine S-methyl transferase (TPMT). "
3.	Abdominal Aortic Aneurysm 01/01/2023 - "Our study investigates the role of lncRNA Nudix Hydrolase 6 (NUDT6) and its antisense target fibroblast growth factor 2 (FGF2) in two vascular pathologies: abdominal aortic aneurysms (AAA) and carotid artery disease. "
4.	Hyperphagia (Overeating) 01/01/2016 - "Hence, hyperphagia-like symptoms in sCSDS mice evidently occurred independently of hypothalamic malonyl-CoA, but might consequently lead to down-regulation of hepatic CoA via altered expression of nudix hydrolase 7. Future studies should investigate the molecular mechanism(s) underlying the down-regulation of liver CoA pools in sCSDS mice. "
5.	Carotid Artery Diseases 01/01/2023 - "Our study investigates the role of lncRNA Nudix Hydrolase 6 (NUDT6) and its antisense target fibroblast growth factor 2 (FGF2) in two vascular pathologies: abdominal aortic aneurysms (AAA) and carotid artery disease. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	2-mercaptopurine
3.	Messenger RNA (mRNA)
4.	Long Noncoding RNA
5.	Prokaryotic Initiation Factor-3
6.	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)
7.	Transferases
8.	RNA (Ribonucleic Acid)
9.	Malonyl Coenzyme A (Malonyl CoA)
10.	Coenzyme A (CoA)

Related Therapies and Procedures

1.	Therapeutics