Solute Carrier Family 12

Inorganic cation-chloride cotransporters mediating the movement of inorganic SODIUM and/or POTASSIUM cations, coupled to the movement of CHLORIDE anions. The solute carrier 12 (SLC12) family can be divided into Na+-dependent SLC12A1-A3 (NKCC1, NKCC2, and NCC) and Na+-independent SLC12A4-A7 (KCC1-KCC4).

Also Known As:

Networked: 13 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Babazono, Tetsuya: 2 articles (10/2005 - 11/2003)
2.	Tanaka, Nobue: 2 articles (10/2005 - 11/2003)
3.	Chen, Peng: 1 article (12/2021)
4.	Cong, Peifang: 1 article (12/2021)
5.	Du, Cheng: 1 article (12/2021)
6.	Hou, Mingxiao: 1 article (12/2021)
7.	Liu, Ying: 1 article (12/2021)
8.	Liu, Yunen: 1 article (12/2021)
9.	Mao, Shun: 1 article (12/2021)
10.	Shi, Lin: 1 article (12/2021)

Related Diseases

1.	Diabetic Nephropathies (Diabetic Nephropathy) 10/01/2005 - "As a result, a single nucleotide polymorphism in exon 23 of the solute carrier family 12 (sodium-chloride cotransporter) member 3 gene was found to be strongly associated with diabetic nephropathy. " 11/01/2003 - "Association of solute carrier family 12 (sodium/chloride) member 3 with diabetic nephropathy, identified by genome-wide analyses of single nucleotide polymorphisms." 07/01/2008 - "Large-scale genotyping efforts performed on Japanese subjects with type 2 diabetes have implicated polymorphisms in solute carrier family 12 (sodium/chloride transporters) member 3 (SLC12A3) as being associated with advanced diabetic nephropathy. " 03/01/2006 - "SLC12A3 (solute carrier family 12 member [sodium/chloride] 3) polymorphisms are associated with end-stage renal disease in diabetic nephropathy." 03/01/2006 - "Previous studies have revealed that polymorphisms in the SLC12A3 (solute carrier family 12 member [sodium/chloride] 3) gene, which encodes solute carrier family 12 member 3, might contribute to genetic susceptibility to diabetic nephropathy and essential hypertension. "
2.	Pediatric Obesity 01/01/2017 - "Backgrounds/Objectives:This panel study was to predict the incidences of pediatric obesity by the interaction of sodium (Na) intake and nine single-nucleotide polymorphisms (SNPs) of salt-sensitive genes (SSGs), ACE(angiotensin-converting enzyme), ADD1 G460W,AGT M235T,CYP11β2 (cytochrome P450 family 11-subfamily β-2, -aldosterone synthase),GNB3 C285T,GRK4(A142V)(G-protein-coupled receptor kinases type 4),GRK4 (A486V),NEDD4L (neural precursor cell expressed developmentally downregulated 4 like; rs2288774) and SLC12A3 (solute carrier family 12 (Na/Cl transporters)-member 3), selected from genome-wide association study. "
3.	Genetic Predisposition to Disease (Genetic Predisposition) 03/01/2006 - "Previous studies have revealed that polymorphisms in the SLC12A3 (solute carrier family 12 member [sodium/chloride] 3) gene, which encodes solute carrier family 12 member 3, might contribute to genetic susceptibility to diabetic nephropathy and essential hypertension. "
4.	Breast Neoplasms (Breast Cancer) 02/01/2021 - "Solute carrier family 12 member 8 impacts the biological behaviors of breast carcinoma cells by activating TLR/NLR signaling pathway." 02/01/2021 - "This study aimed to understand the expression of solute carrier family 12 member 8 (SLC12A8) in breast carcinoma and its biological functions, as well as its effect on the Toll-like receptor /NOD-like receptor (TLR/NLR) signaling pathway. "
5.	Essential Hypertension 03/01/2006 - "Previous studies have revealed that polymorphisms in the SLC12A3 (solute carrier family 12 member [sodium/chloride] 3) gene, which encodes solute carrier family 12 member 3, might contribute to genetic susceptibility to diabetic nephropathy and essential hypertension. "

Related Drugs and Biologics

1.	Sodium Chloride
2.	Member 3 Solute Carrier Family 12
3.	G-Protein-Coupled Receptor Kinases
4.	Toll-Like Receptors (Toll-Like Receptor)
5.	Cytochrome P-450 CYP11B2 (CYP11B2)
6.	Sodium
7.	Salts
8.	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
9.	Cytochrome P450 Family 11
10.	NLR Proteins