Neuroligins

Postsynaptic cell-adhesion molecules that bind presynaptic NEUREXINS to form calcium-dependent trans-synaptic adhesions. Neuroligins recruit synaptic scaffolding proteins (e.g., PSD-95) via their PDZ DOMAIN. The distribution and interaction with neurexins are regulated by ALTERNATIVE SPLICING. Alterations in genes encoding neuroligins or neurexins are associated with cognitive diseases such as AUTISM SPECTRUM DISORDER.

Also Known As:

Networked: 180 relevant articles (1 outcomes, 24 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Südhof, Thomas C: 12 articles (01/2020 - 06/2005)
2.	Comoletti, Davide: 10 articles (02/2016 - 06/2005)
3.	Taylor, Palmer: 9 articles (09/2010 - 06/2005)
4.	De Jaco, Antonella: 6 articles (12/2020 - 12/2005)
5.	Xie, Wei: 5 articles (10/2022 - 09/2013)
6.	Calahorro, Fernando: 5 articles (01/2021 - 12/2011)
7.	Tabuchi, Katsuhiko: 5 articles (01/2021 - 06/2011)
8.	Roche, Katherine W: 4 articles (01/2021 - 01/2017)
9.	Brose, Nils: 4 articles (01/2020 - 09/2006)
10.	Craig, Ann Marie: 4 articles (01/2018 - 02/2013)

Related Diseases

1.	Autism Spectrum Disorder 08/01/2023 - "Expression alteration of Neuroligin family gene in attention deficit and hyperactivity disorder and autism spectrum disorder." 01/01/2022 - "The development of autism spectrum disorders (ASDs) involves both environmental factors such as maternal diabetes and genetic factors such as neuroligins (NLGNs). " 01/01/2021 - "We cloned degus Neurexin and Neuroligin as sociality-related genes, which are genetically related to autism spectrum disorder in human. " 12/01/2020 - "The neuroligins and the synaptic pathway in Autism Spectrum Disorder." 01/01/2020 - "Elevated Plasma X-Linked Neuroligin 4 Expression Is Associated with Autism Spectrum Disorder."
2.	Schizophrenia (Dementia Praecox) 01/01/2015 - "Neurexin-Neuroligin Synaptic Complex Regulates Schizophrenia-Related DISC1/Kal-7/Rac1 "Signalosome"." 02/28/2006 - "Screening for Neuroligin 4 (NLGN4) truncating and transmembrane domain mutations in schizophrenia." 10/01/2022 - "Deletions or mutations in the neuroligins genes have been found in patients with both autism and schizophrenia. " 01/01/2018 - "The prototypical synapse-organizing complex neurexin-neuroligin mediates synapse development and function and is central to a shared genetic risk pathway in autism and schizophrenia. " 01/01/2015 - "Some symptoms and mutated genes, including neuroligin (NLGN), neurexin (NRXN), and SH3 and multiple ankyrin repeat domains protein (SHANK), are shared by schizophrenia and ASD. "
3.	Skeletal Abnormalities Mandibular Hypoplasia Auditory Canal Atresia Short Stature 01/01/2023 - "We discovered that T1D mice exhibited partially decreased levels of excitatory and inhibitory synapse proteins and SAMs, such as neurexins, neuroligins, and synaptic cell adhesion molecules. " 01/01/2017 - "Many SAMs, including neurexins, neuroligins, cadherins, and contactins, are now implicated in neuropsychiatric and neurodevelopmental diseases, such as autism spectrum disorder, schizophrenia, and bipolar disorder and studying their molecular mechanisms holds promise for developing novel therapeutics."
4.	Bipolar Disorder (Manic Depressive Psychosis) 01/01/2017 - "Many SAMs, including neurexins, neuroligins, cadherins, and contactins, are now implicated in neuropsychiatric and neurodevelopmental diseases, such as autism spectrum disorder, schizophrenia, and bipolar disorder and studying their molecular mechanisms holds promise for developing novel therapeutics."
5.	Autistic Disorder (Autism) 01/01/2021 - "Indeed, in animal studies designed to model autism, there remains controversy regarding the role of neuroligin dysfunction in the expression of disrupted social behaviours. " 01/01/2020 - "In this study, we compared plasma levels of neuroligin 4 (NLGN4) in children with autism versus matched healthy controls to examine a possible correlation between plasma NLGN4 and degree of autism severity as well as social impairment in autistic patients. " 07/09/2013 - "Here, we integrate data from these studies into a model of how neuroligin functions to control synaptic connectivity in the central nervous system and how neuroligin dysfunction may participate in the pathophysiology of autism. " 07/09/2013 - "Molecular and functional links between syndromic and nonsyndromic autism genes were lacking until studies aimed at understanding the role of trans-synaptic adhesion molecule neuroligin, which is associated with nonsyndromic autism, provided important connections. " 12/01/2011 - "Numerous studies have associated autism with mutations in several genes involved in excitatory and inhibitory synapses in the mammalian brain, including neuroligin, neurexin and shank, for which there are C. "

Related Drugs and Biologics

1.	Neurexins
2.	Contactins
3.	Cadherins (E-Cadherin)
4.	Proteins (Proteins, Gene)
5.	N-acetyltalosaminuronic acid (NAT)
6.	neuroligin 3
7.	Glutamic Acid (Glutamate)
8.	gamma-Aminobutyric Acid (GABA)
9.	Ghrelin
10.	Brain-Derived Neurotrophic Factor (BDNF)

Related Therapies and Procedures

1.	Therapeutics