Cannabinoid Hyperemesis Syndrome

Recurrent vomiting accompanied by nausea, abdominal pain and sometimes compulsive hot bathing behavior in chronic CANNABIS abuse.

Also Known As:

Cannabinoid Hyperemesis Syndromes; Cannabis Hyperemesis Syndromes; Hyperemesis Syndrome, Cannabinoid; Hyperemesis Syndrome, Cannabis; Syndrome, Cannabinoid Hyperemesis; Syndrome, Cannabis Hyperemesis; Cannabis Hyperemesis Syndrome

Networked: 97 relevant articles (8 outcomes, 4 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Vomiting
2.	Abdominal Pain (Pain, Abdominal)
3.	Nausea
4.	Familial cyclic vomiting syndrome
5.	Gastroparesis

Experts

1.	Burillo-Putze, Guillermo: 5 articles (04/2022 - 12/2016)
2.	Richards, John R: 4 articles (04/2022 - 01/2017)
3.	DeVuono, Marieka V: 4 articles (01/2022 - 01/2020)
4.	Parker, Linda A: 4 articles (01/2022 - 01/2020)
5.	Hill, Matthew N: 3 articles (01/2022 - 01/2020)
6.	Limebeer, Cheryl L: 3 articles (01/2022 - 01/2020)
7.	Petrie, Gavin N: 3 articles (01/2022 - 01/2020)
8.	Rock, Erin M: 3 articles (01/2022 - 01/2020)
9.	La Caprara, Olivia: 2 articles (01/2022 - 07/2020)
10.	Ruberto, Aaron J: 2 articles (01/2021 - 01/2019)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cannabinoid Hyperemesis Syndrome:

1.	Capsaicin (Zostrix)FDA Link 11/01/2021 - "Efficacy of topical capsaicin for cannabinoid hyperemesis syndrome in a pediatric and adult emergency department." 01/01/2021 - "Efficacy of topical capsaicin for the treatment of cannabinoid hyperemesis syndrome: A retrospective cohort study." 11/01/2019 - "Efficacy of Capsaicin for the Treatment of Cannabinoid Hyperemesis Syndrome: A Systematic Review." 01/01/2022 - "There are few studies in Spain on cannabinoid hyperemesis syndrome (CHS), as well as on the use of topical capsaicin as a treatment. " 11/01/2020 - "A Pilot Trial of Topical Capsaicin Cream for Treatment of Cannabinoid Hyperemesis Syndrome."
2.	CannabinoidsIBA 01/01/2023 - "The objectives of this study were to characterize the detailed cannabis use patterns (eg, frequency, mode, and product) and determine the differences in the whole-blood cannabinoid profiles during symptomatic versus asymptomatic periods of participants with suspected cannabinoid hyperemesis syndrome recruited from the emergency department (ED) during a symptomatic episode. " 11/23/2023 - "As more states legalize cannabinoid products for recreational use and medicinal purposes the prevalence of cannabinoid hyperemesis syndrome has become increasingly common. " 01/01/2023 - "Cannabis Use Patterns and Whole-Blood Cannabinoid Profiles of Emergency Department Patients With Suspected Cannabinoid Hyperemesis Syndrome." 01/01/2023 - "The most commonly mentioned triggers for cannabinoid hyperemesis syndrome episodes included: food and drink (n = 62), cannabinoids (n = 45), mental health (e.g., stress, anxiety) (n = 27), and alcohol (n = 22). " 02/01/2021 - "The ability to identify and treat cannabinoid-associated illnesses such as cannabinoid hyperemesis syndrome, withdrawal syndrome, and acute intoxication with synthetic cannabinoids can reduce morbidity. "
3.	Haloperidol (Haldol)FDA LinkGeneric 01/01/2017 - "Haloperidol, a Novel Treatment for Cannabinoid Hyperemesis Syndrome." 09/01/2022 - "Treatment of Cannabis Hyperemesis Syndrome Using Haloperidol in a Pregnant Patient: Case Report." 01/01/2022 - "Haloperidol as a treatment option in cannabinoid hyperemesis syndrome." 11/01/2018 - "A short-cut review was carried out to establish whether haloperidol is effective at treating the symptoms of cannabinoid hyperemesis syndrome (CHS). " 11/01/2018 - "BET 1: Haloperidol in cannabinoid hyperemesis syndrome."
4.	MMEIBA 05/05/2021 - "The objective of this study was to evaluate whether haloperidol decreases MME for the treatment of non-specific abdominal pain diagnoses in the emergency department (ED), including gastroparesis, cyclic vomiting, cannabinoid hyperemesis syndrome, and unspecified abdominal pain. "
5.	AntiemeticsIBA 01/01/2023 - "Comparison of Antiemetics in the Management of Pediatric Cannabinoid Hyperemesis Syndrome." 03/01/2022 - "QTc prolongation in cannabis hyperemesis syndrome patients exposed to antiemetics: A retrospective chart review." 01/01/2018 - "Without other identifiable causes, she was diagnosed with cannabinoid hyperemesis syndrome and managed with antiemetics and abstinence. " 01/01/2017 - "Cannabinoid hyperemesis syndrome (CHS) is typically unresponsive to conventional pharmacologic antiemetics, and patients often require excessive laboratory and radiographic testing and hospital admission. " 01/20/2016 - "The antiemetic properties of marijuana are well known, but there is increasing evidence of its paradoxical hyperemetic effects on the gastrointestinal tract and central nervous system, known as 'cannabinoid hyperemesis syndrome' (CHS). "
6.	Dronabinol (THC)FDA LinkGeneric 12/01/2021 - "Cannabinoid Hyperemesis Syndrome Secondary to Delta-8 THC Use." 01/01/2016 - "A case report of a severe cannabis hyperemesis syndrome (CHS) is presented, which had worsened during dronabinol administration and was associated with intestinal dysmotility (pseudo-obstruction). " 01/01/2022 - "Introduction: Cannabinoid hyperemesis syndrome (CHS) is characterized by intense nausea and vomiting brought on by the use of high-dose Δ9-tetrahydrocannabinol (THC), the main psychotropic compound in cannabis. " 01/01/2022 - "Background: Cannabinoid hyperemesis syndrome (CHS) is a diagnosis of exclusion with intractable nausea, cyclic vomiting, abdominal pain, and hot bathing behavior associated with ongoing tetrahydrocannabinol (THC) exposure. " 02/01/2023 - "Cannabinoid hyperemesis syndrome (CHS) is associated with tetrahydrocannabinol, and rarely has been reported with cannabidiol. "
7.	EndocannabinoidsIBA 01/01/2022 - "Endocannabinoid system and cannabis hyperemesis syndrome: a narrative update." 01/01/2018 - "The relief of cannabinoid hyperemesis syndrome symptoms from heat and use of transient receptor potential vanilloid 1 agonists suggests a complex interrelation between the endocannabinoid system and transient receptor potential vanilloid 1. Temperature regulation: Hot water hydrotherapy is a mainstay of self-treatment for cannabinoid hyperemesis syndrome patients. " 07/01/2020 - "Dysregulation of the endocannabinoid (eCB) system by high doses of Δ9-tetrahydrocannabinol (THC) is hypothesized to generate a dysfunctional hypothalamic-pituitary-adrenal (HPA) axis contributing to cannabinoid hyperemesis syndrome (CHS). " 01/01/2018 - "These complex interactions between the endocannabinoid systems and transient receptor potential vanilloid 1, in the setting of cannabinoid receptor desensitization, may yield important clues into the pathophysiology and treatment of cannabinoid hyperemesis syndrome. " 01/01/2018 - "The action of topical capsaicin may mimic the effect of heat-activation of transient receptor potential vanilloid 1. Endocannabinoid system and transient receptor potential vanilloid 1: Cannabinoid hyperemesis syndrome may result from a derangement in the endocannabinoid system secondary to chronic exogenous stimulation. "
8.	SmokeIBA 04/01/2014 - "Cannabinoid hyperemesis syndrome: cyclical vomiting behind the cloud of smoke." 04/01/2022 - "Cannabinoid hyperemesis syndrome (CHS) is an uncommon but unique disorder defined by recurrent abdominal pain, intractable nausea, and emesis in patients who regularly smoke cannabis. " 01/01/2018 - "Cannabinoid hyperemesis syndrome and topical capsaicin: treating smoke with fire?" 01/01/2018 - "Cannabinoid hyperemesis syndrome and topical capsaicin: treating smoke with fire? "
9.	CannabidiolIBA 12/01/2020 - "Does cannabidiol induce cannabinoid hyperemesis syndrome?" 02/01/2023 - "A Rare Case of Cannabinoid Hyperemesis Syndrome Secondary to Cannabidiol for Refractory Epilepsy." 02/01/2023 - "Cannabinoid hyperemesis syndrome (CHS) is associated with tetrahydrocannabinol, and rarely has been reported with cannabidiol. " 05/01/2023 - "A synopsis of the endocannabinoid system provides a basis for the hypothesis that a lack of cannabidiol in modern high-potency Δ 9 -tetrahydrocannabinol cannabis may be contributory to cannabis hyperemesis syndrome and possibly other cannabis use disorders. "
10.	Ondansetron (Zofran)FDA LinkGeneric 01/01/2021 - "Intravenous Haloperidol Versus Ondansetron for Cannabis Hyperemesis Syndrome (HaVOC): A Randomized, Controlled Trial." 01/01/2021 - "We compare haloperidol with ondansetron for cannabis hyperemesis syndrome. " 01/01/2021 - "Intravenous Haloperidol Versus Ondansetron for Cannabis Hyperemesis Syndrome (HaVOC): A Randomized, Controlled Trial."

Therapies and Procedures

1.	Baths 10/28/2020 - "The use of hot baths, the rapid improvement in symptoms, and results of complementary examinations suggested a diagnosis of cannabinoid hyperemesis syndrome. " 07/01/2021 - "Cannabinoid Hyperemesis Syndrome (CHS) is 1 outcome of chronic cannabis use, which presents as cyclic intractable vomiting that can be temporarily relieved with hot baths or showers. " 02/01/2014 - "We present here a case of cannabinoid hyperemesis syndrome (CHS), which is an under-recognised disorder presenting in chronic abusers of cannabis typically as cyclical vomiting relieved by frequent hot baths. " 06/01/2020 - "Cannabinoid hyperemesis syndrome (CHS) is characterized by cyclical episodes of nausea and vomiting, accompanied by abdominal pain following prolonged, high-dose cannabis use, which is alleviated by hot baths and showers. " 09/01/2019 - "Introduction: Cannabinoid hyperemesis syndrome (CHS) can be characterized by recurrent paroxysmal episodes of intractable nausea and vomiting, abdominal pain, and compulsive hot showers/baths with symptom relief, on the background of chronic cannabis use. "
2.	Therapeutics 01/01/2023 - "We sought to describe common themes discussed and the most frequently mentioned triggers and therapies for cannabinoid hyperemesis syndrome exacerbations in the Reddit online community. " 04/01/2021 - "This case describes unique management with coronary artery bypass and surgical thrombectomy because of the patient's inability to tolerate uninterrupted antiplatelet therapy given her cannabinoid hyperemesis syndrome. " 01/01/2016 - "Cannabinoid hyperemesis syndrome (CHS) is seldom responsive to traditional antiemetic therapies. " 01/01/2023 - "Most commonly mentioned cannabinoid hyperemesis syndrome therapies included: hot water/bathing (n = 62), hydration (n = 60), antiemetics (n = 42), food and drink (n = 38), gastrointestinal medications (n = 38), behavioral therapies (e.g., meditation, yoga) (n = 35), and capsaicin (n = 29). "
3.	Palliative Care (Palliative Therapy) 01/01/2022 - "A Case Report on Cannabinoid Hyperemesis Syndrome in Palliative Care: How Good Intentions Can Go Wrong." 10/01/2019 - "Cannabis Hyperemesis Syndrome in Palliative Care: A Case Study and Narrative Review."
4.	Meditation 01/01/2023 - "Most commonly mentioned cannabinoid hyperemesis syndrome therapies included: hot water/bathing (n = 62), hydration (n = 60), antiemetics (n = 42), food and drink (n = 38), gastrointestinal medications (n = 38), behavioral therapies (e.g., meditation, yoga) (n = 35), and capsaicin (n = 29). "
5.	Thrombectomy 04/01/2021 - "This case describes unique management with coronary artery bypass and surgical thrombectomy because of the patient's inability to tolerate uninterrupted antiplatelet therapy given her cannabinoid hyperemesis syndrome. "