Olivary Degeneration

Degeneration of the OLIVARY NUCLEUS typically involving INFERIOR OLIVARY COMPLEX. It is associated with various syndromes and neurodegenerative disorders including hypertrophic olivary degeneration secondary to a Guillain-Mollaret triangle lesion.

Also Known As:

Degeneration, Hypertrophic Olivary; Degeneration, Olivary; Degeneration, Olivary Nucleus; Hypertrophic Olivary Degenerations; Hypertrophy, Inferior Olivary; Inferior Olivary Hypertrophies; Olivary Degeneration, Hypertrophic; Olivary Degenerations; Olivary Hypertrophy, Inferior; Olivary Nucleus Degenerations; Hypertrophic Olivary Degeneration; Hypertrophic Olivary Nucleus Degeneration; Inferior Olivary Hypertrophy; Olivary Nucleus Degeneration

Networked: 12 relevant articles (0 outcomes, 3 trials/studies)

Disease Context: Research Results

Nervous System Diseases: 14178
- Neurodegenerative Diseases: 42472
  - Olivary Degeneration: 12

Related Diseases

1.	Fatal Familial Insomnia
2.	Brain Diseases (Brain Disorder)
3.	Infratentorial Neoplasms (Posterior Fossa Tumors)
4.	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome)
5.	Spasm (Spasms)

Experts

1.	Dong, Xiang: 1 article (07/2021)
2.	Gao, Bingbing: 1 article (07/2021)
3.	Liu, Yangyingqiu: 1 article (07/2021)
4.	Miao, Yanwei: 1 article (07/2021)
5.	Calver, Ronelle: 1 article (06/2020)
6.	Deng, Zhihui: 1 article (06/2020)
7.	Fleet, Jamie L: 1 article (06/2020)
8.	Perera, Gihan C: 1 article (06/2020)
9.	Baumgarten, Peter: 1 article (12/2019)
10.	Foerch, Christian: 1 article (12/2019)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Olivary Degeneration:

1.	IonsIBA 07/26/2019 - "Recent structural MRI studies have found an association between PFS and hypertrophic olivary degeneration, which is detectable as T2 hyperintensity in the inferior olivary nuclei (IONs) months after surgery. "
2.	HemosiderinIBA 05/01/1997 - "Magnetic resonance studies at 4 and 10 months showed residual hemosiderin in the pons and increasing hypertrophic olivary degeneration (HOD) affecting primarily the left olive. "
3.	Prion ProteinsIBA 01/01/2019 - "Transmission studies revealed that the typical fatal familial insomnia with thalamic and olivary degeneration showed successful transmission only using knock-in mice expressing human-mouse chimeric prion protein gene. "
4.	Metronidazole (Metric)FDA LinkGeneric 12/01/2003 - "We observed inferior olivary hypertrophy, believed to be the result of lesions in the midbrain and cerebellar white matter rather than the result of lesions induced by metronidazole therapy. " 03/01/2010 - "[Reversible metronidazole-induced encephalopathy and hypertrophic olivary degeneration]." 12/01/2003 - "Metronidazole-induced encephalopathy and inferior olivary hypertrophy: lesion analysis with diffusion-weighted imaging and apparent diffusion coefficient maps."
5.	Valproic Acid (Depakote)FDA LinkGeneric 06/03/2020 - "Anticonvulsants, such as gabapentin and divalproex sodium, may reduce the severity of gastrointestinal symptoms in cases associated with hypertrophic olivary degeneration. "
6.	IronIBA 07/01/2021 - "Iron deposits in the red nucleus at long-term follow-up after hypertrophic olivary degeneration."
7.	Indicators and Reagents (Reagents)IBA 04/01/2014 - "In the appropriate clinical setting, bilateral hypertrophic olivary degeneration may be a sensitive and specific indicator of posterior fossa syndrome." 04/01/2014 - "Hypertrophic olivary degeneration may be a surrogate imaging indicator for damage to the contralateral proximal efferent cerebellar pathway. "
8.	GadoliniumIBA 05/01/2014 - "Hypertrophic olivary degeneration with gadolinium enhancement after posterior fossa surgery in a child with medulloblastoma."
9.	Carbamazepine (Tegretol)FDA LinkGeneric 01/01/2023 - "Successful treatment of paroxysmal painful tonic spasms with carbamazepine in a patient with hypertrophic olivary degeneration."
10.	Anticonvulsants (Antiepileptic Drugs)IBA 06/03/2020 - "Anticonvulsants, such as gabapentin and divalproex sodium, may reduce the severity of gastrointestinal symptoms in cases associated with hypertrophic olivary degeneration. "

Therapies and Procedures

1.	Therapeutics 12/16/2019 - "Delayed Occurrence of Hypertrophic Olivary Degeneration after Therapy of Posterior Fossa Tumors: A Single Institution Retrospective Analysis." 09/01/2013 - "Acquired pendular nystagmus and its therapy in progressive supranuclear palsy (PSP) due to inferior olivary hypertrophy." 12/01/2003 - "We observed inferior olivary hypertrophy, believed to be the result of lesions in the midbrain and cerebellar white matter rather than the result of lesions induced by metronidazole therapy. "
2.	Enteral Nutrition (Feeding, Tube) 06/03/2020 - "Palato-pharyngo-laryngeal myoclonus with recurrent retrograde feeding tube migration after cerebellar hemorrhagic stroke: a case report and review of hypertrophic olivary degeneration."