Angucyclines and Angucyclinones

Polycyclic aromatic polyketides with tetracyclic angular benz(a)anthracene skeletons. Angucyclines and related angucyclinones are produced by Actinomycetes, e.g., STREPTOMYCES, using type II polyketide synthase involving condensation of acetyl CoA and 9 malonyl-CoA.

Also Known As:

Angucyclinones and Angucyclines; Angucycline Aglycons; Angucycline Antibiotics; Angucycline and Angucyclinone Derivatives; Angucyclines; Angucyclinone Antibiotics; Angucyclinones

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Fukaya, Keisuke: 1 article (01/2022)
2.	Harunari, Enjuro: 1 article (01/2022)
3.	Igarashi, Yasuhiro: 1 article (01/2022)
4.	Imada, Chiaki: 1 article (01/2022)
5.	In, Yasuko: 1 article (01/2022)
6.	Oku, Naoya: 1 article (01/2022)
7.	Urabe, Daisuke: 1 article (01/2022)
8.	Yang, Taehui: 1 article (01/2022)
9.	Zhang, Zhiwei: 1 article (01/2022)
10.	Chase, Alexander B: 1 article (01/2021)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2021 - "Grincamycins P-T: Rearranged Angucyclines from the Marine Sediment-Derived Streptomyces sp. CNZ-748 Inhibit Cell Lines of the Rare Cancer Pseudomyxoma Peritonei." 12/01/2018 - "The cytotoxic activity of the new synthesized compounds and five angucyclinones, previously reported, was evaluated in vitro against three cancer cell lines: PC-3 (prostate cancer), HT-29 (colon cancer), MCF-7 (breast cancer), and one non-tumoral cell line, human colon epithelial cells (CCD841 CoN). "
2.	Pseudomyxoma Peritonei 01/01/2021 - "Grincamycins P-T: Rearranged Angucyclines from the Marine Sediment-Derived Streptomyces sp. CNZ-748 Inhibit Cell Lines of the Rare Cancer Pseudomyxoma Peritonei."
3.	Prostatic Neoplasms (Prostate Cancer) 12/01/2018 - "The cytotoxic activity of the new synthesized compounds and five angucyclinones, previously reported, was evaluated in vitro against three cancer cell lines: PC-3 (prostate cancer), HT-29 (colon cancer), MCF-7 (breast cancer), and one non-tumoral cell line, human colon epithelial cells (CCD841 CoN). "
4.	Leukemia 01/01/2022 - "The absolute configuration of SF2315B was also determined by comparison of ECD spectra with those of 1 and 2. All the angucyclinones exhibited cytotoxicity against P388 murine leukemia cells, with IC50 values ranging from 1.8 to 53 μM."
5.	Hepatocellular Carcinoma (Hepatoma) 11/27/2018 - "Among the isolated angucyclines, saquayamycin B (4) displayed potent cytotoxic activity against hepatoma carcinoma cells HepG-2, SMMC-7721 and plc-prf-5, with IC50 values 0.135, 0.033 and 0.244 μM respectively, superior to doxorubicin. "

Related Drugs and Biologics

1.	PPAR gamma
2.	Doxorubicin (Adriamycin)
3.	saquayamycin B
4.	SF 2315B