Trace Amine-Associated Receptors

G-protein coupled receptors that interact with trace amine compounds (e.g., P-OCTOPAMINE; BETA-PHENYLETHYLALMINE; TRYPTAMINE; P-TYRAMINE) which are present at low tissue levels in mammals. Most human trace amine-associated receptors are expressed in olfactory epithelium neurons.

Also Known As:

Networked: 17 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Jun, Tae-Youn: 2 articles (09/2008 - 01/2008)
2.	Kim, Jung-Jin: 2 articles (09/2008 - 01/2008)
3.	Lee, Chul: 2 articles (09/2008 - 01/2008)
4.	Pae, Chi-Un: 2 articles (09/2008 - 01/2008)
5.	Paik, In-Ho: 2 articles (09/2008 - 01/2008)
6.	Patkar, Ashwin A: 2 articles (09/2008 - 01/2008)
7.	Lerer, Bernard: 2 articles (08/2008 - 01/2008)
8.	Gainetdinov, Raul R: 1 article (11/2022)
9.	Kuvarzin, Savelii R: 1 article (11/2022)
10.	Sycheva, Anastasia M: 1 article (11/2022)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 10/18/2023 - "Trace amine-associated receptors (TAARs), which were discovered only in 2001, are known to be involved in the regulation of a spectrum of neuronal processes and may play a role in the pathogenesis of a number of neuropsychiatric diseases, such as schizophrenia and others. " 02/01/2009 - "The trace amine associated receptor (TAAR6) gene is not associated with schizophrenia in the Irish Case-Control Study of Schizophrenia (ICCSS) sample." 09/01/2008 - "We recently reported an association between TAAR6 (trace amine associated receptor 6 gene) variations and schizophrenia (SZ). " 08/01/2008 - "We conclude that trace amine associated receptor 6 is not important for the development of schizophrenia in our family samples." 08/01/2008 - "Single nucleotide polymorphisms (SNPs) in the trace amine associated receptor trace amine associated receptor 6 gene and 3' flanking region have been shown to be associated with schizophrenia. "
2.	Mood Disorders (Mood Disorder) 11/15/2008 - "Several recent studies report an association between trace amine-associated receptor 6 (TAAR6) and susceptibility to schizophrenia and bipolar affective disorder in humans. " 03/01/2020 - "Genes coding for trace amine-associated receptors (taars) represent a multigene family of G-protein-coupled receptors, clustered to a small genomic region of 108 kb located in chromosome 6q23, which has been consistently identified by linkage analyses as a susceptibility locus for schizophrenia and affective disorders. "
3.	Bipolar Disorder (Manic Depressive Psychosis) 02/01/2006 - "No association of the trace amine-associated receptor 6 with bipolar disorder in a northern Swedish population." 01/01/2008 - "Previous studies have reported association of the trace amine associated receptor 6 (TAAR6) gene with susceptibility to schizophrenia and bipolar disorder but results have not been consistent. " 01/01/2008 - "Association of the trace amine associated receptor 6 (TAAR6) gene with schizophrenia and bipolar disorder in a Korean case control sample."
4.	Parkinson Disease (Parkinson's Disease) 03/10/2006 - "Observations associated with the distribution of these trace amine associated receptors (TAARs) suggest that they may be involved in depression, attention-deficit hyperactivity disorder, eating disorders, migraine headaches, and Parkinson's disease. " 01/01/2022 - "Human trace amine-associated receptor subtype 1 (hTAAR1) is a G protein-coupled receptor that has therapeutic potential for multiple diseases, including schizophrenia, drug addiction, and Parkinson's disease (PD). " 05/30/2020 - "Implicated in various diseases including Parkinson's disease, Huntington's disease, migraines, schizophrenia and increased blood pressure, tyramine plays a crucial role as a neurotransmitter in the synaptic cleft by reducing serotonergic and dopaminergic signaling through a trace amine-associated receptor (TAAR1). "
5.	Migraine Disorders (Migraine) 03/10/2006 - "Observations associated with the distribution of these trace amine associated receptors (TAARs) suggest that they may be involved in depression, attention-deficit hyperactivity disorder, eating disorders, migraine headaches, and Parkinson's disease. " 05/30/2020 - "Implicated in various diseases including Parkinson's disease, Huntington's disease, migraines, schizophrenia and increased blood pressure, tyramine plays a crucial role as a neurotransmitter in the synaptic cleft by reducing serotonergic and dopaminergic signaling through a trace amine-associated receptor (TAAR1). "

Related Drugs and Biologics

1.	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)
2.	Neurotransmitter Agents (Neurotransmitter)
3.	Tyramine
4.	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)
5.	Dopamine Receptors (Dopamine Receptor)
6.	Ligands
7.	SEP-363856