Axl Receptor Tyrosine Kinase

A member of the Tyro3-Axl-Mer (TAM) RECEPTOR PROTEIN-TYROSINE KINASES subfamily. Involved in several cellular functions including growth, migration, cell aggregation, and anti-inflammation.

Networked: 103 relevant articles (2 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lorens, James B: 5 articles (01/2021 - 09/2015)
2.	Torka, Robert: 4 articles (01/2019 - 01/2014)
3.	Ullrich, Axel: 4 articles (10/2017 - 04/2006)
4.	Pandey, Akhilesh: 3 articles (08/2021 - 11/2010)
5.	Gausdal, Gro: 3 articles (01/2021 - 01/2019)
6.	Belkhiri, Abbes: 3 articles (12/2018 - 01/2013)
7.	Hong, Jun: 3 articles (12/2018 - 01/2013)
8.	Baumann, Christine: 3 articles (10/2017 - 01/2014)
9.	Maitra, Anirban: 3 articles (11/2014 - 04/2009)
10.	Rothlin, Carla V: 2 articles (11/2021 - 01/2021)

Related Diseases

1.	Triple Negative Breast Neoplasms 01/01/2017 - "AXL receptor tyrosine kinase is overexpressed in a number of solid tumor types including triple-negative breast cancer (TNBC). " 06/01/2017 - "Purpose: AXL receptor tyrosine kinase has been described as a relevant molecular marker and a key player in invasiveness, especially in triple-negative breast cancer (TNBC).Experimental Design: We evaluate the antitumor efficacy of the anti-AXL monoclonal antibody 20G7-D9 in several TNBC cell xenografts or patient-derived xenograft (PDX) models and decipher the underlying mechanisms. " 08/01/2016 - "Protein kinase C α is involved in the regulation of AXL receptor tyrosine kinase expression in triple-negative breast cancer cells." 08/01/2016 - "AXL receptor tyrosine kinase is overexpressed in triple-negative breast cancer (TNBC), and has a function in cancer progression and metastases. " 01/01/2014 - "Taken together, our findings highlight the importance of combinatorial or multikinase inhibition of non-receptor tyrosine kinases and AXL receptor tyrosine kinase in the therapy of triple negative breast cancer. "
2.	Nephritis 01/01/2018 - "Targeted inhibition of Axl receptor tyrosine kinase ameliorates anti-GBM-induced lupus-like nephritis."
3.	Neoplasms (Cancer) 11/05/2023 - "AXL receptor tyrosine kinase inhibition improves the anti-tumor effects of CD8+ T cells by inducing CD103+ dendritic cell-mediated T cell priming." 01/01/2023 - "The aggressive features of GI cancers share distinct signaling pathways that are connected to each other by the overexpression and activation of AXL receptor tyrosine kinase. " 08/23/2021 - "Overexpression and amplification of AXL receptor tyrosine kinase (RTK) has been found in several hematologic and solid malignancies. " 05/01/2021 - "AXL receptor tyrosine kinase (AXL) upregulation mediates drug resistance in several types of human cancer and has become a therapeutic target worthy of exploration. " 01/01/2020 - "AXL receptor tyrosine kinase is a mediator of cancer cell phenotypic plasticity and suppression of tumor immunity, and AXL expression is associated with drug resistance and diminished long-term survival in a wide range of malignancies, including NSCLC. "
4.	Carcinogenesis 01/01/2014 - "The AXL receptor tyrosine kinase has been implicated in several kinds of cancers, but so far no studies have investigated the role of AXL in NF1 related tumorigenesis. " 10/27/2017 - "Axl receptor tyrosine kinase critically involves in the carcinogenesis of multiple cancers due to its dual roles in both promoting cancer invasion and metastasis and suppressing myeloid cell activation and function. " 01/01/2017 - "Axl receptor tyrosine kinase is involved in the tumorigenesis and metastasis of many cancers. " 12/01/2017 - "In cancer models, warfarin inhibits AXL receptor tyrosine kinase-dependent tumorigenesis and enhances antitumor immune responses at doses not reaching anticoagulation levels. " 08/01/2007 - "Mer is one member of Axl receptor tyrosine kinase family, and its ligand Gas6 can stimulate activity of Mer receptor tyrosine kinase after binding it, and then activate the downstream signal transduction pathway, Mer participates in cell inflammation, apoptosis, tumorigenesis, thrombosis and hemostasis. "
5.	B-Cell Lymphoma (Lymphoma, B Cell) 03/01/2017 - "In the present study, the messenger RNA (mRNA) expression levels of B-cell lymphoma 2 interacting mediator of cell death (BIM), astrocyte elevated gene-1 (AEG-1) and AXL receptor tyrosine kinase (AXL) were investigated in 131 advanced GC samples, and the expression levels of these genes were correlated with patients' overall survival (OS). "

Related Drugs and Biologics

1.	Monoclonal Antibodies
2.	antiglomerular basement membrane antibody
3.	Proteins (Proteins, Gene)
4.	Warfarin (Coumadin)
5.	Messenger RNA (mRNA)
6.	ErbB Receptors (EGF Receptor)
7.	Connective Tissue Growth Factor
8.	Microphthalmia-Associated Transcription Factor
9.	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)
10.	RNA (Ribonucleic Acid)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Immunotherapy