DNA Polymerase iota

A highly error-prone DNA polymerase. It is a member of the Y-family of DNA polymerases that are DNA DAMAGE tolerant and involved in TRANSLESION DNA SYNTHESIS. DNA polymerase iota is an orthologue of yeast Rad30. Its replication fidelity is template dependent and favors Hoogsteen base-pairing at its active site.

Also Known As:

Networked: 24 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Zhou, Jundong: 6 articles (01/2021 - 08/2012)
2.	Wu, Jinchang: 5 articles (01/2021 - 08/2012)
3.	Ding, Wei-Qun: 4 articles (01/2021 - 08/2012)
4.	Zou, Shitao: 4 articles (01/2021 - 01/2015)
5.	Gening, L V: 4 articles (01/2013 - 01/2006)
6.	Tarantul, V Z: 4 articles (01/2013 - 01/2006)
7.	Gao, Aidi: 3 articles (01/2021 - 12/2017)
8.	He, Chao: 3 articles (01/2021 - 12/2017)
9.	Zhang, Shuyu: 3 articles (05/2016 - 08/2012)
10.	Grishina, E E: 3 articles (01/2013 - 01/2006)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2021 - "Our previous study demonstrated that DNA polymerase iota (Pol ι) is overexpressed in ESCC tumors and correlates with poor prognosis. " 01/01/2013 - "The obtained results suggest that IKL5 might be used to suppress the enhanced activity of Pol iota in tumor cells." 01/01/2013 - "[Effect of Mn(II) on the error-prone DNA polymerase iota activity in extracts from human normal and tumor cells]." 07/01/2010 - "Effect of human cell malignancy on activity of DNA polymerase iota." 11/28/2006 - "Although pol iota deficiency alone had no effect, UV-induced skin tumors in pol eta-deficient mice developed 4 weeks earlier in mice concomitantly deficient in pol iota. "
2.	Carcinogenesis 08/15/2006 - "Involvement of DNA polymerase iota in hypermutagenesis and tumorigenesis: an improper model can lead to inaccurate results." 10/01/2006 - "These results suggest the involvement of the Pol eta and Pol iota proteins in UV-induced skin carcinogenesis." 05/01/2005 - "Pol iota is a member of the Y-family DNA polymerases, characterized by their capacity for translesion DNA synthesis and low fidelity base incorporation, and has therefore been assumed to play important roles in mutagenesis and carcinogenesis. " 03/15/2004 - "Thus, our data support the Pol iota gene as a modifier of lung tumorigenesis by altering DNA polymerase activity."
3.	Esophageal Squamous Cell Carcinoma 01/01/2021 - "DNA Polymerase Iota Promotes Esophageal Squamous Cell Carcinoma Proliferation Through Erk-OGT-Induced G6PD Overactivation." 08/01/2012 - "Overexpression of DNA polymerase iota (Polι) in esophageal squamous cell carcinoma." 12/01/2017 - "Phosphorylation of ETS-1 is a critical event in DNA polymerase iota-induced invasion and metastasis of esophageal squamous cell carcinoma." 05/31/2016 - "DNA polymerase iota (Pol ι) promotes invasion and metastasis of esophageal squamous cell carcinoma."
4.	Neoplasm Metastasis (Metastasis) 12/01/2017 - "Phosphorylation of ETS-1 is a critical event in DNA polymerase iota-induced invasion and metastasis of esophageal squamous cell carcinoma." 05/31/2016 - "DNA polymerase iota (Pol ι) promotes invasion and metastasis of esophageal squamous cell carcinoma."
5.	Lung Neoplasms (Lung Cancer) 09/01/2018 - "siRNA of DNA polymerase iota inhibits the migration and invasion in the lung cancer cell A549." 03/15/2004 - "Altered expression of POL iota protein and an amino acid-changing nucleotide polymorphism were observed in human lung cancer cells, suggesting a possible role in the development of lung cancer. "

Related Drugs and Biologics

1.	DNA Polymerase iota
2.	DNA (Deoxyribonucleic Acid)
3.	Enzymes
4.	DNA-Directed DNA Polymerase (Polymerases, DNA)
5.	Cell Extracts
6.	Proteins (Proteins, Gene)
7.	Rad30 protein
8.	Small Interfering RNA (siRNA)
9.	Vitamin K 3 (Menadione)
10.	Nonsense Codon (Nonsense Mutation)