Sinistral Portal Hypertension

Portal hypertension of the SPLENIC VEIN due to occlusion caused by pancreatic pathology such as PANCREATIC PSEUDOCYST and PANCRATIC CANCER. Sinistral portal hypertension is associated with GASTRIC VARICES and acute HEMATEMESIS.

Also Known As:

Hypertension, Left-Sided Portal; Hypertension, Segmental Portal; Hypertension, Sinistral Portal; Left Sided Portal Hypertension; Left-Sided Portal Hypertensions; Portal Hypertension, Left-Sided; Portal Hypertension, Segmental; Portal Hypertension, Sinistral; Segmental Portal Hypertensions; Sinistral Portal Hypertensions; Left-Sided Portal Hypertension; Segmental Portal Hypertension

Networked: 90 relevant articles (7 outcomes, 6 trials/studies)

Relationship Network

Disease Context: Research Results

Digestive System Diseases: 1042
- Liver Diseases: 41660
  - Portal Hypertension: 7261
    - Sinistral Portal Hypertension: 90

Related Diseases

1.	Hemorrhage
2.	Portal Hypertension
3.	Pathologic Constriction (Stenosis)
4.	Embolism (Embolus)
5.	Pancreatic Neoplasms (Pancreatic Cancer)

Experts

1.	Saiura, Akio: 5 articles (10/2021 - 01/2019)
2.	Inoue, Yosuke: 4 articles (10/2021 - 01/2019)
3.	Ito, Hiromichi: 4 articles (10/2021 - 01/2019)
4.	Matsueda, Kiyoshi: 4 articles (10/2021 - 01/2019)
5.	Ono, Yoshihiro: 4 articles (10/2021 - 01/2019)
6.	Takahashi, Yu: 4 articles (10/2021 - 01/2019)
7.	Addeo, Pietro: 4 articles (09/2020 - 12/2011)
8.	Mizuno, Shugo: 3 articles (05/2022 - 01/2017)
9.	Hiratsuka, Makiko: 3 articles (01/2021 - 01/2019)
10.	Tanaka, Masayuki: 3 articles (01/2021 - 01/2019)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Sinistral Portal Hypertension:

1.	EnbucrilateIBA 06/26/2022 - "Modified endoscopic ultrasound-guided selective N-butyl-2-cyanoacrylate injections for gastric variceal hemorrhage in left-sided portal hypertension: A case report." 07/01/2022 - "The patient was diagnosed with gastric varices associated with left-sided portal hypertension caused by obstruction of the splenic vein and underwent percutaneous transsplenic embolization with n-butyl-2-cyanoacrylate mixed with lipiodol. "
2.	Pancrelipase (Creon)FDA Link 08/01/1986 - "Left-sided portal hypertension from malignant islet cell tumour of the pancrease: review with a case report."
3.	Proteins (Proteins, Gene)FDA Link 11/01/2002 - "A 22-year-old woman presented with lump in the left hypochondrium, refractory high-protein ascites and evidence of left-sided portal hypertension. "
4.	Atrial Natriuretic Factor (ANF)IBA 09/01/2017 - "Acute necrotizing pancreatitis (ANP) is complicated with segmental portal hypertension (PHT) and formation of venous collaterals. "
5.	Hemoglobins (Hemoglobin)IBA 06/01/2015 - "Here we report an exceedingly unusual case in a 9-year-old boy who had developed left-sided portal hypertension after surgical treatment for pancreatoblastoma followed by a duodenal variceal bleeding with massive melena, severe anemia (hemoglobin 4.5 g/dL) and hypovolemic shock. "
6.	Glucose (Dextrose)FDA LinkGeneric 08/10/2019 - "Independent risk factors for sinistral portal hypertension were male gender (OR, 4.666; 95% CI, 2.54-8.572; P<0.001), recurrent acute pancreatitis (OR, 9.556; 95% CI, 5.218-17.5; P<0.001), hypertriglyceridemia (OR, 2.056; 95% CI, 1.184-3.57; P=0.001), glucose >10 mmol/L (OR, 6.965; 95% CI, 4.027-12.045; P<0.001), smoking (OR, 6.32; 95% CI, 3.544-11.269; P<0.001), and infection of walled-off necrosis (OR=1.637; 95% CI, 1.061-2.524; P=0.015). "
7.	Ethiodized Oil (Ethiodol)FDA Link 07/01/2022 - "The patient was diagnosed with gastric varices associated with left-sided portal hypertension caused by obstruction of the splenic vein and underwent percutaneous transsplenic embolization with n-butyl-2-cyanoacrylate mixed with lipiodol. "
8.	antineoplaston A10 (A 10)IBA 06/01/1997 - "Thrombosis of the splenic vein with left-sided portal hypertension is common and associated with a 10% incidence of gastric variceal hemorrhage, which requires splenectomy. "
9.	A 7 (A-7)IBA 10/01/2010 - "We present this case of a 38-year-old female patient with a three-week history of abdominal pain and an abdominal CT scan revealing a 7 cm mass near the spleen and tail of pancreas with segmental portal hypertension. "

Therapies and Procedures

1.	Splenectomy 01/01/2014 - "Splenic artery embolization may be a valuable adjunct in case of left-sided portal hypertension requiring splenectomy, allowing a safe dissection of the splenic vessels even by laparoscopy." 01/01/2014 - "Left-sided portal hypertension: Successful management by laparoscopic splenectomy following splenic artery embolization." 09/01/2010 - "Later, splenectomy was performed in order to relieve left-sided portal hypertension. " 07/01/2006 - "Splenectomy or embolization is an option in patients with segmental portal hypertension." 01/01/2003 - "It may be reasonable to perform a splenectomy concomitantly when the splenic vein is to be resected or ligated during pancreatic surgery to avoid the future development of left-sided portal hypertension. "
2.	Pancreaticoduodenectomy 11/01/2021 - "SRS is a safe and effective measure to mitigate gastric congestion and left-sided portal hypertension after pancreatoduodenectomy with compromised gastric venous drainage after resection of the portal venous confluence." 09/01/2020 - "A systematic literature search was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement to identify all studies published up to September 30, 2019 reporting data on patients with left-sided portal hypertension after pancreatoduodenectomy with venous resection. " 12/01/2022 - "Successful Use of Direct Splenic Vein Anastomosis to the Interposition Internal Jugular Vein Graft after Extended Pancreatoduodenectomy to Avoid Sinistral Portal Hypertension." 05/01/2022 - "Left-sided portal hypertension (LSPH) caused by splenic vein (SV) division in pancreaticoduodenectomy (PD) with portal vein (PV) resection remains challenging. " 10/24/2021 - "Sinistral Portal Hypertension after Pancreaticoduodenectomy with Splenic Vein Resection: Pathogenesis and Its Prevention."
3.	Colectomy 01/01/1998 - "Of the 2 patients with left-sided portal hypertension, one died after splenectomy and one rebled 6 months after left colectomy. " 09/01/2020 - "Treatment of left-sided portal hypertension consisted of splenectomy in 3 cases (21%) and colectomy in 1 (7%) case, whereas radiologic, endoscopic procedures or conservative treatments were effective in the other cases (71%). "
4.	Conservative Treatment 09/01/2020 - "Treatment of left-sided portal hypertension consisted of splenectomy in 3 cases (21%) and colectomy in 1 (7%) case, whereas radiologic, endoscopic procedures or conservative treatments were effective in the other cases (71%). "
5.	Ligation 09/01/2020 - "Left-sided portal hypertension occurred in 7.7% of patients who had splenic vein preservation and 29.4% of those having splenic vein ligation. " 01/01/2019 - "Although splenic vein ligation can cause sinistral portal hypertension, the incidence of clinically relevant sinistral portal hypertension remains unknown, and the roles of the preservation of potential collateral veins and splenic vein reconstruction are controversial. " 02/01/2015 - "Splenic vein ligation may result in sinistral (left-sided) portal hypertension and gastrointestinal haemorrhage. " 05/01/2014 - "Simple SV ligation can result in sinistral portal hypertension if the inferior mesenteric vein (IMV) enters the confluence and is thereby resected, or if the IMV is insufficient to drain the SV. " 11/01/2011 - "Ligation of the splenic vein close to its termination in five patients resulted in a pattern of venous return different from patients that have developed left-sided portal hypertension."