Corneal Cross-Linking

An ophthalmic treatment used to prevent weakening or bulging of the CORNEA in corneal ECTASIA, e.g., post-LASIK ectasia, KERATOCONUS and pellucid marginal corneal degeneration. It uses UV-A and RIBOFLAVIN to crosslink and strengthen COLLAGEN fibers within the cornea.

Also Known As:

CXL, Epi-off; CXL, Epi-on; CXL, Epithelium-off; CXL, Epithelium-on; CXL, Transepithelial; Collagen Cross-Linking, Corneal; Collagen Cross-Linkings, Corneal; Corneal Collagen Cross Linking; Corneal Collagen Cross-Linkings; Corneal Cross Linking; Corneal Cross-Linking, Epi-off; Corneal Cross-Linking, Epithelium-off; Corneal Cross-Linking, Epithelium-on; Corneal Cross-Linking, Transepithelial; Corneal Cross-Linkings; Cross-Linking, Corneal; Cross-Linking, Corneal Collagen; Cross-Linking, Epi-off Corneal; Cross-Linking, Epithelium-off Corneal; Cross-Linking, Epithelium-on Corneal; Cross-Linking, Transepithelial Corneal; Cross-Linkings, Corneal Collagen; Epi off CXL; Epi off Corneal Cross Linking; Epi on CXL; Epi-off CXLs; Epi-off Corneal Cross-Linkings; Epi-on CXLs; Epithelium off CXL; Epithelium off Corneal Cross Linking; Epithelium on CXL; Epithelium on Corneal Cross Linking; Epithelium-off CXLs; Epithelium-off Corneal Cross-Linkings; Epithelium-on CXLs; Epithelium-on Corneal Cross-Linkings; Transepithelial CXLs; Transepithelial Corneal Cross Linking; Transepithelial Corneal Cross-Linkings; Corneal Collagen Cross-Linking; Epi-off CXL; Epi-off Corneal Cross-Linking; Epi-on CXL; Epithelium-off CXL; Epithelium-off Corneal Cross-Linking; Epithelium-on CXL; Epithelium-on Corneal Cross-Linking; Transepithelial CXL; Transepithelial Corneal Cross-Linking

Networked: 1031 relevant articles (143 outcomes, 161 trials/studies)

Relationship Network

Therapy Context: Research Results

Therapeutics: 1158551

Experts

1.	Hafezi, Farhad: 47 articles (09/2022 - 10/2006)
2.	Kymionis, George D: 27 articles (01/2022 - 05/2009)
3.	Vinciguerra, Paolo: 16 articles (06/2022 - 03/2009)
4.	Vinciguerra, Riccardo: 16 articles (06/2022 - 03/2009)
5.	Hashemi, Hassan: 14 articles (06/2022 - 08/2013)
6.	Grentzelos, Michael A: 14 articles (01/2022 - 02/2011)
7.	Mazzotta, Cosimo: 14 articles (05/2021 - 08/2007)
8.	Zhou, Xingtao: 13 articles (01/2022 - 01/2016)
9.	Asgari, Soheila: 12 articles (06/2022 - 08/2013)
10.	Richoz, Olivier: 12 articles (02/2021 - 07/2013)

Related Diseases

1.	Keratoconus 10/01/2023 - "Customised peripheral corneal cross-linking (P-CXL) treated very severe keratoconus with a success rate of 85.7% and improved visual acuity and tomographic indicators in most cases. " 12/01/2015 - "Corneal cross-linking can halt the progression of keratoconus, but what is the best approach for treatment? " 10/03/2021 - "Background: Corneal collagen cross-linking (CXL) has recently become the preferred practice in the management of progressive keratoconus and other corneal ectasias as it has been proven to be successful in halting progression of the disease with an excellent safety and efficacy profile. " 08/01/2021 - "Deep learning of the As-OCT color-coded maps effectively discriminates progressive keratoconus from non-progressive keratoconus with an accuracy of approximately 85% using the adjusted age algorithm, indicating that it will become an aid for predicting the progression of the disease, which is clinically beneficial for decision-making of the surgical indication of corneal cross-linking (CXL)." 02/01/2012 - "Transepithelial CXL treatment appeared to halt keratoconus progression, with a statistically significant improvement in visual and topographic parameters. "
2.	Keratitis 01/07/2022 - "We tested whether standalone photoactivated chromophore corneal cross-linking (PACK-CXL) may be an effective first-line treatment in early to moderate infectious keratitis, compared with standard antimicrobial treatment. " 10/01/2016 - "Although corneal collagen cross-linking may be an effective treatment for Acremonium keratitis refractory to medical therapy, corneal transplant was required for visual gain and recovery." 06/06/2014 - "Corneal collagen cross-linking seems to be a safe and effective therapeutic alternative in resistant cases of infectious keratitis following penetrating keratoplasty." 03/02/2018 - "Antimicrobial efficacy of corneal cross-linking in vitro and in vivo for Fusarium solani: a potential new treatment for fungal keratitis." 01/01/2020 - "To investigate the efficacy of photoactivated chromophore corneal collagen cross-linking (PACK)-CXL in the management of treatment-resistant infectious keratitis. "
3.	Pathologic Dilatation (Ectasia) 07/01/2015 - "Corneal collagen cross-linking performed after ICRS implantation is an important complementary treatment in preventing the progression of ectasia, whereas subsequent treatment with either photorefractive keratectomy or toric intraocular lens implantation offers a significantly improved visual and refractive result. " 12/01/2018 - "Although patients in the transepithelial CXL group demonstrated a greater improvement in BSCVA compared with patients in the epi-off CXL group at the 1 year follow-up, transepithelial CXL had less impact on halting progressive corneal ectasia in terms of maximum K than epi-off CXL." 06/01/2015 - "Accelerated corneal collagen cross-linking seems to be safe and effective in halting postoperative LASIK ectasia progression after 2 years of follow-up. " 05/01/2014 - "Implantation of intrastromal corneal ring segment implantation combined with same-day corneal collagen cross-linking was a safe and effective treatment for ectasia occurring after LASIK. " 01/01/2021 - "To evaluate the safety and efficacy of transepithelial corneal cross-linking in comparison with the established epithelium-off technique for corneal ectasia. "
4.	Ulcer 02/01/2013 - "The aim of this study is to evaluate the efficacy of corneal collagen cross-linking in resistant corneal ulcers. " 01/01/2015 - "To evaluate the efficacy of corneal collagen cross-linking (CXL) for treatment of corneal ulcers not responding to antimicrobial therapy. " 05/01/2016 - "Corneal cross-linking in the treatment of corneal ulcers." 01/01/2016 - "The evaluation of the efficiency of corneal cross linking in the management of corneal ulcers. " 01/01/2015 - "Corneal Collagen Cross-linking for Treatment of Non-healing Corneal Ulcers."
5.	Allergic Conjunctivitis (Giant Papillary Conjunctivitis) 04/01/2019 - "The purpose of the study is to determine the safety and efficacy of corneal collagen cross-linking for keratoconus in pediatric patients with and without vernal keratoconjunctivitis (VKC). " 01/01/2017 - "The purpose of this study was to assess the safety and efficacy of femtosecond laser-assisted Keraring implantation followed by transepithelial accelerated corneal collagen cross-linking (CXL) for the treatment of keratoconus in children with vernal keratoconjunctivitis (VKC). " 04/01/2019 - "Safety and Efficacy of Corneal Cross-linking in Pediatric Patients with Keratoconus and Vernal Keratoconjunctivitis." 01/01/2019 - "To assess the 3-year safety and efficacy of femtosecond laser-assisted intrastromal corneal ring segments' (ICRS) implantation followed or accompanied by transepithelial accelerated corneal collagen cross-linking (TE-ACXL) as a treatment of keratoconus in children with vernal keratoconjunctivitis (VKC). " 01/01/2022 - "Allergic conjunctivitis (AC) is one of the reported potential risk factors of progression in keratoconus patients after corneal cross-linking surgery; however, the causal relationship is still inconclusive. "

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3.	Collagen
4.	Oxygen (Dioxygen)
5.	Solutions
6.	Dextrans (Dextran)
7.	Rose Bengal
8.	Fatty Acids (Saturated Fatty Acids)
9.	Alkalies
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Related Therapies and Procedures

1.	Therapeutics
2.	Corneal Cross-Linking
3.	Photorefractive Keratectomy
4.	Laser In Situ Keratomileusis (LASIK)
5.	Lasers (Laser)