Betulinic Acid

06/18/2007 - "Broad in vitro efficacy of plant-derived betulinic acid against cell lines derived from the most prevalent human cancer types."
01/09/2009 - "Betulinic acid (BA) has anti cancer and anti-HIV activity and has been proved to be therapeutically effective against cancerous and HIV-infected cells. "
10/05/2017 - "Development and evaluation of long-circulating nanoparticles loaded with betulinic acid for improved anti-tumor efficacy."
06/08/2020 - "However, relevant studies on betulinic acid in inhibiting cancer were insufficient and the molecular mechanism was unclear. "
01/01/2020 - "The aim of this study was to prepare and evaluate betulinic acid nanosuspension (BA-NS) for new drug delivery to enhance its solubility and in vitro anti-tumor activity. "

01/01/2021 - "Betulinic Acid (BA) is a lipophilic compound with proven beneficial results in topical inflammation. "
02/04/2022 - "TLR9 inhibition also alleviated inflammation and apoptosis, which was reversed by the addition of the NF-κB activator, betulinic acid. "
02/01/2019 - "We also observed that treatment with betulinic acid attenuated synovial inflammation and joint destruction in mice with CIA. "
08/01/2019 - "Betulinic acid suppresses Th17 response and ameliorates psoriasis-like murine skin inflammation."
10/15/2016 - "Betulinic acid ameliorates experimental diabetic-induced renal inflammation and fibrosis via inhibiting the activation of NF-κB signaling pathway."

08/25/2022 - "The present study shows that betulinic acid significantly inhibits the growth of melanoma cell lines in vitro. "
09/01/2005 - "This study was designed to investigate the cell signaling pathway leading human melanoma cells to increased resistance to betulinic acid treatment. "
12/01/2002 - "This study investigates the regulation and expression of Mcl-1 in human melanoma cells, which was recently found to be induced by betulinic acid, a compound with anti-melanoma and apoptosis-inducing potential. "
11/12/2022 - "The current paper aims to obtain a C30-1,2,4-triazole derivative of betulinic acid simultaneously acetylated at C3 whose biological activity was tested against RPMI melanoma cells. "
08/25/2022 - "The IC50 values of betulinic acid ranged from 2.21 µM to 15.94 µM against the four melanoma lines. "

01/01/2019 - "A promising betulinic acid analogue (2c) with better therapeutic efficacy than parent molecule to colon carcinoma cells has been reported. "
04/01/2004 - "Recently, considerable in vitro evidence has demonstrated that betulinic acid is effective against small- and non-small-cell lung, ovarian, cervical, and head and neck carcinomas. "
09/18/2015 - "Synthesis and biological evaluation of a novel betulinic acid derivative as an inducer of apoptosis in human colon carcinoma cells (HT-29)."
01/01/2015 - "Betulinic acid selectively inhibits the growth of ovarian carcinoma cell lines without affecting the normal cells. "
08/22/2013 - "Betulinic acid (BA) is a natural product that exerts its cytotoxicity against various malignant carcinomas without side effects by triggering the mitochondrial pathway to apoptosis. "

01/21/2022 - "Betulinic acid self-assembled nanoparticles for effective treatment of glioblastoma."
04/15/2020 - "Betulinic Acid-Mediated Tuning of PERK/CHOP Signaling by Sp1 Inhibition as a Novel Therapeutic Strategy for Glioblastoma."
10/30/2014 - "Betulinic acid derivatives NVX-207 and B10 for treatment of glioblastoma--an in vitro study of cytotoxicity and radiosensitization."
10/30/2014 - "Betulinic acid (BA), a pentacyclic triterpene, represents a new therapeutic substance that has potential benefits for treating glioblastoma. "
02/01/2013 - "Here, we discover that the PI3K inhibitor GDC-0941 acts in concert with the natural compound B10, a glycosylated derivative of betulinic acid, to induce cell death in glioblastoma cells. "