Glycated Proteins

Advanced glycation end products formed from the spontaneous, non-enzymatic reaction of sugars with free amino groups in proteins. In the past, a glycosylated protein sometimes referred to a glycated protein. GLYCOSYLATED PROTEINS is now restricted to proteins glycosylated by GLYCOSYLTRANSFERASES or via specialized organic chemistry reactions.

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Networked: 121 relevant articles (5 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ziyadeh, Fuad N: 4 articles (11/2008 - 06/2005)
2.	Bach, Leon A: 3 articles (09/2012 - 07/2003)
3.	Kijewska, Monika: 3 articles (12/2011 - 12/2009)
4.	Kluczyk, Alicja: 3 articles (12/2011 - 12/2009)
5.	Stefanowicz, Piotr: 3 articles (12/2011 - 12/2009)
6.	Szewczuk, Zbigniew: 3 articles (12/2011 - 12/2009)
7.	Metz, Thomas O: 3 articles (02/2009 - 06/2007)
8.	Smith, Richard D: 3 articles (02/2009 - 06/2007)
9.	Zhang, Qibin: 3 articles (02/2009 - 06/2007)
10.	Wolf, Gunter: 3 articles (02/2008 - 06/2005)

Related Diseases

1.	Diabetic Nephropathies (Diabetic Nephropathy) 09/01/2000 - "In vivo studies further corroborate the role of glycated proteins in the pathogenesis of diabetic nephropathy. " 01/01/2001 - "In early diabetes, increasing concentrations of circulating glycated proteins could be responsible for changes in glomerular permselectivity and probably for the alteration in glomerular filtration properties leading to diabetic nephropathy." 05/01/1998 - "Thus, the GEC are metabolically sensitive to the presence of glycated proteins, and this could play a role in the pathogenesis of diabetic nephropathy." 01/01/1996 - "Localization of glycated proteins in the glomeruli of patients with diabetic nephropathy." 10/01/2011 - "Early diabetic nephropathy is characterized by glomerular hyperpermeability as a result of impaired glomerular filtration structure caused by hyperglycemia, glycated proteins or irreversible advanced glycosylation endproducts (AGE). "
2.	Hyperglycemia 08/01/2001 - "Striking similarities in the mechanism by which hyperglycemia and glycated proteins induce vascular dysfunction suggest that a common pathway mediates effects of these different metabolic imbalances on vascular dysfunction." 11/23/2018 - "This association persists even after glycemic control has been achieved, suggesting an innate mechanism of "metabolic memory." AGEs are glycated proteins that may serve as mediators of metabolic memory due to their increased production in the setting of hyperglycemia and generally slow turnover. " 10/01/2011 - "Early diabetic nephropathy is characterized by glomerular hyperpermeability as a result of impaired glomerular filtration structure caused by hyperglycemia, glycated proteins or irreversible advanced glycosylation endproducts (AGE). " 02/01/2008 - "On a molecular level, metabolic pathways activated by hyperglycemia, glycated proteins, hemodynamic factors, and oxidative stress are key players in the genesis of diabetic kidney disease. " 04/01/1993 - "To test whether treatment with aminoguanidine, a drug known to prevent cross-linking between glycated proteins, is effective in improving reduced erythrocyte deformability in diabetes, we studied a group (n = 6) of ALX-induced long-term (12.7 +/- 2.2 mo of hyperglycemia) diabetic New Zealand white rabbits before and after 20 wk of treatment with aminoguanidine (100 mg.kg-1 x day-1). "
3.	Type 2 Diabetes Mellitus (MODY) 09/01/2008 - "Randomized controlled trials of patients with type 2 diabetes have confirmed the beneficial effects of nuts on blood lipids also seen in nondiabetic subjects, but the trials have not reported improvement in A1c or other glycated proteins. " 11/01/2014 - "Role of Amadori products of glycated proteins in the induction of autoantibodies in type 2 diabetes as well as in associated secondary complications has been discussed." 09/01/2008 - "To investigate how liver disease alter the serum glycated proteins as markers of diabetic control, we studied serum GA, A1c and especially GA/A1c ratio in 255 patients having over 35IU/L in ALT(transaminase) compared with those of 829 type 2 diabetes mellitus (DM) in cross sectional manner. " 05/01/2008 - "Although most of the glycated proteins could be identified in samples from individuals with normal glucose tolerance, slightly higher numbers of glycated proteins and more glycation sites were identified in samples from individuals with impaired glucose tolerance and type 2 diabetes mellitus." 05/01/2008 - "In this work, we report the first proteomics-based characterization of nonenzymatically glycated proteins in human plasma and erythrocyte membranes from individuals with normal glucose tolerance, impaired glucose tolerance, and type 2 diabetes mellitus. "
4.	Diabetes Complications 10/17/2017 - "The Role of Glycated Proteins on Cardiovascular Diabetic Complications: New Findings." 10/01/2013 - "Glycated proteins are considered as one of the factors involved in the pathogenesis of diabetic complications, including nephropathy. " 09/18/1998 - "Transition metals bind to glycated proteins forming redox active "glycochelates": implications for the pathogenesis of certain diabetic complications." 01/01/1988 - "The possibility of O2- formation from glycated proteins may explain some long term complications of diabetes mellitus." 01/01/1996 - "Our data using mutant Cu,Zn-SOD related to familial amyotrophic lateral sclerosis (FALS) suggest that glycation itself and ROI produced from the glycated proteins are involved in many diseases, including diabetic complications. "
5.	Inflammation (Inflammations) 01/01/2020 - "The aim was to investigate the levels of glycated proteins and their correlation with periodontal and systemic inflammation. " 02/11/2023 - "The accumulation of oxidatively modified and glycated proteins is associated with inflammation and the progression of chronic diseases (aging). " 10/01/2019 - "Glycated proteins in infant formula may cause inflammation that could disturb tolerance induction and lead to autoimmune disease." 04/01/2010 - "Glycated proteins can induce activation of microglia, which exacerbate the pathology of Alzheimer's disease by causing chronic inflammation. " 10/01/2022 - "In addition, endogenous complement inhibitors can be glycated, whereas diet-derived glycated proteins can themselves promote complement activation, worsening DKD, and lending support for environmental influences as an additional avenue for propagating complement-induced inflammation and kidney injury. "

Related Drugs and Biologics

1.	Albumins
2.	Proteins (Proteins, Gene)
3.	Insulin (Novolin)
4.	Lipids
5.	Calpain
6.	pimagedine (aminoguanidine)
7.	Sorbitol (Yal)
8.	Cation Transport Proteins
9.	Pyruvic Acid (Pyruvate)
10.	benzeneboronic acid

Related Therapies and Procedures

1.	Therapeutics
2.	Glycemic Control
3.	Lenses