Bicornuate Uterus

A congenital uterine anomaly in which the UTERUS is divided into two uterine horns with a significant cleft at the uterine fundus due to partial fusion of the MULLERIAN DUCTS. Bicornuate uterus is sometimes associated with a longitudinal vaginal septum and abnormal development of renal tracts.

Also Known As:

Bicolli, Bicornuate; Bicollis Uterus, Bicornuate; Bicollis, Bicornuate; Bicornuate Bicolli; Unicollis Uterus, Bicornuate; Unicollis, Bicornuate; Uterus, Bicornuate Bicollis; Uterus, Bicornuate Unicollis; Bicornuate Bicollis; Bicornuate Bicollis Uterus; Bicornuate Unicollis; Bicornuate Unicollis Uterus; Double Uterus and Longitudinal Vaginal Septum

Networked: 80 relevant articles (0 outcomes, 3 trials/studies)

Disease Context: Research Results

Urogenital Diseases: 126
- Female Urogenital Diseases and Pregnancy Complications
  - Female Urogenital Diseases
    - Female Genital Diseases: 393
      - Uterine Diseases: 433
        Uterine Duplication Anomalies: 21
        Bicornuate Uterus: 80

Related Diseases

1.	Septate Uterus
2.	Rupture
3.	Hemorrhage
4.	Uterine Didelphys
5.	Abdominal Pregnancy

Experts

1.	Singh, Uma: 2 articles (08/2018 - 01/2013)
2.	Verma, Manju Lata: 2 articles (08/2018 - 01/2013)
3.	Getu, Jenenu: 1 article (03/2022)
4.	Utalo, Tadiwos: 1 article (03/2022)
5.	Cheon, Chong Kun: 1 article (01/2022)
6.	Keum, Changwon: 1 article (01/2022)
7.	Yoo, Sukdong: 1 article (01/2022)
8.	Yoon, Ju Young: 1 article (01/2022)
9.	Gürsoy, Semra: 1 article (08/2021)
10.	Hazan, Filiz: 1 article (08/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Bicornuate Uterus:

1.	Levonorgestrel (Plan B)FDA LinkGeneric 06/01/2023 - "Intrauterine devices (IUDs) have become one of the most frequently used forms of long-acting reversible contraception (LARC) in women of childbearing age. While complications are generally considered to be minimal, they can occur during the insertion, during use, or upon removal. Uterine anomalies, such as a bicornuate uterus, can increase the risk of complications during all stages. Here, we describe a case of a patient with a bicornuate uterus who had a levonorgestrel IUD in place for five years before she experienced a dislodging of the IUD, fragmentation upon attempted removal, and ultimately required a hysteroscopy to remove an embedded fragment from the endocervical canal. Due to the limited reporting on fragmented IUDs, further studies will be required to assess the optimal management. While symptomatic patients should have the fragment removed, asymptomatic patients should have their individual history and desire for future pregnancy weighed against the risk and benefits of treatment." 01/01/2016 - "Levonorgestrel Intrauterine Device Placement in a Premenopausal Breast Cancer Patient with a Bicornuate Uterus." 07/01/1998 - "Successful management of intractable menorrhagia with a levonorgestrel-releasing intrauterine device, in a woman with a bicornuate uterus."
2.	Silk FDA Link 05/09/2015 - "In group I, a 2-cm 3-0 silk suture was placed into one horn of the rat bicornuate uterus. " 06/01/2007 - "In groups II and III, a string of 3/0 silk suture of 2 cm long was transcervically placed in one of the horns of the bicornuate uterus of the rat. "
3.	Tamoxifen FDA LinkGeneric 01/01/2016 - "LNG-IUD placement in a young patient with a personal history of breast cancer on tamoxifen and a bicornuate uterus is a safe and feasible alternative for contraception. " 12/01/2004 - "There are a few reports of endometrioid carcinoma arising in a bicornuate uterus, but none of these discuss a serous papillary component or an association with tamoxifen therapy. "
4.	PlasticsIBA 01/01/1985 - "The authors present a series of 45 plastic operations for bicornuate uterus. " 01/01/1952 - "[Plastic operation of Strassman for bicornuate uterus]."
5.	Diethylstilbestrol (Stilbestrol)FDA Link 03/01/2020 - "The American Fertility Society, European Society of Human Reproduction and Embryology, and the European Society of Gynaecological Endoscopy classify malformations as: Class 1/U5bC4V4: agenesis or hypoplasia of uterus and vagina; Class 1/U5aC4V4: cervical hypoplasia, associated with total or partial vaginal agenesis; Class 2/U4: unicornuate uterus; Class 3/U3bC2V1 or Class3/U3bC2V2: uterus didelphys; Class 4/U3C0: bicornuate uterus; Class 5/U2: septate uterus; Class 6: arcuate uterus; Class 7/U1: induced by diethylstilbestrol, represented by a T-shaped uterus; and V3: transverse vaginal septum. " 05/01/2010 - "Using 3D ultrasound we diagnosed: one case with uterine agenesis; 10 with unicornuate uterus, four of which also underwent MRI; six with didelphic uterus, one of which had MRI; 45 with bicornuate uterus, 12 of which had MRI; 125 with septate uterus (18 with two cervices), 42 of which had MRI (six with two cervices); 96 with arcuate uterus, three of which had MRI; and three with diethylstilbestrol (DES) iatrogenic uterine malformations, all of which had MRI. "
6.	NFI Transcription FactorsIBA 03/01/2001 - "Splice site mutation in the hepatocyte nuclear factor-1 beta gene, IVS2nt + 1G > A, associated with maturity-onset diabetes of the young, renal dysplasia and bicornuate uterus."
7.	Ephrin-B1 (Ephrin B1)IBA 08/01/2021 - "A novel EFNB1 gene mutation (c.65delG; p.Cys22SerfsTer24) was detected in a newborn who had only dysmorphic facial features and bicornuate uterus. "
8.	Raloxifene Hydrochloride (Evista)FDA Link 05/01/2005 - "A malignant mixed mesodermal tumor was diagnosed in a 64-year-old woman with a bicornuate uterus while she was taking raloxifene for osteoporosis prevention. "
9.	Mifepristone (RU 486)FDA Link 12/01/2006 - "To report a case of mifepristone-induced abortion in only one horn but a growing fetus in another horn for a twin pregnancy in a bicornuate uterus. " 12/01/2006 - "Mifepristone-induced abortion in one horn and a growing fetus in another horn in a patient with a twin pregnancy in a bicornuate uterus."
10.	Progesterone FDA LinkGeneric 03/01/2023 - "Pelvic magnetic resonance imaging revealed a bicornuate uterus in patient 1 and uterine hypoplasia with thinning of the endometrium in patient 2. The progesterone challenge test revealed no withdrawal of bleeding. "

Therapies and Procedures

1.	Intrauterine Devices (Intrauterine Device) 06/01/2023 - "Cervically Embedded Fragment of an Intrauterine Device in a Patient with a Bicornuate Uterus: A Case Report and Review of Current Management Strategies." 02/01/2005 - "Three-dimensional sonography of a fetus and an intrauterine device in a bicornuate uterus." 03/01/1992 - "Intrauterine contraceptive device and embryo sharing a bicornuate uterus: case report." 12/01/1970 - "Perforation of bicornuate uterus by intrauterine contraceptive device." 01/01/1990 - "[The use of the Medusa-type intrauterine contraceptive device in treating uterine synechiae in a woman with a bicornuate uterus. "
2.	Catheters 01/01/1992 - "This study analyzes uterine motility in 12 women with a bicornuate uterus using the results of the recordings of endo-uterine pressure, obtained with two balloon-closed catheters. "
3.	Vaginal Birth after Cesarean 09/30/2023 - "This study found that parturients with a bicornuate uterus who attempted TOLAC have a relatively high overall rate of vaginal birth after cesarean (VBAC). "
4.	Long-Acting Reversible Contraception 06/01/2023 - "Intrauterine devices (IUDs) have become one of the most frequently used forms of long-acting reversible contraception (LARC) in women of childbearing age. While complications are generally considered to be minimal, they can occur during the insertion, during use, or upon removal. Uterine anomalies, such as a bicornuate uterus, can increase the risk of complications during all stages. Here, we describe a case of a patient with a bicornuate uterus who had a levonorgestrel IUD in place for five years before she experienced a dislodging of the IUD, fragmentation upon attempted removal, and ultimately required a hysteroscopy to remove an embedded fragment from the endocervical canal. Due to the limited reporting on fragmented IUDs, further studies will be required to assess the optimal management. While symptomatic patients should have the fragment removed, asymptomatic patients should have their individual history and desire for future pregnancy weighed against the risk and benefits of treatment."
5.	Laparotomy 01/01/2022 - "We present the diagnostic difficulties, the therapeutic aspects and the obstetric prognosis of an unusual case of a unicervical bicornuate uterus revealed during a laparotomy which is both exploratory and diagnostic. " 07/01/2014 - "However, findings at laparotomy revealed a non-communicating bicornuate unicollis uterus with damaged right tube (hyrosalpinx) and normal ovaries and left tube. " 01/01/2013 - "Laparotomy revealed bicornuate uterus with ruptured rudimentary horn. " 07/01/2009 - "The surgical technique consisted of median laparotomy with identification of the bicornuate uterus and resection of a 2-cm segment of the right uterine horn. " 03/01/2007 - "Pregnancy termination via laparotomy in a woman with bicornuate uterus."