Prorenin Receptor

08/01/2013 - "Because insulin resistance is associated with increased blood pressure, we investigated whether they develop higher blood pressure with activated renal renin-angiotensin system and whether this is mediated, in part, by the upregulation of renal (pro)renin receptor (PRR) expression. "
01/01/2011 - "Possible involvement of the (pro)renin receptor-dependent system in the development of insulin resistance."
01/01/2023 - "Soluble (Pro)Renin Receptor Level in Patients with Severe Obesity Is Associated with Visceral Adiposity and Is Involved with Insulin Resistance and Renal Injury."
09/15/2014 - "(Pro)renin receptor in skeletal muscle is involved in the development of insulin resistance associated with postinfarct heart failure in mice."
01/01/2017 - "Soluble pro-renin receptor (s [Pro] RR) as a biomarker reflects the activation of renin-angiotensin system in tissues which may be related to insulin resistance Objective: The aim of this study was to determine the role of (s [pro] RR) in predicting GDM. "

01/01/2021 - "(Pro)renin receptor has emerged as a new member of the renin-angiotensin system implicated in the pathogenesis of chronic kidney disease (CKD). "
05/01/2014 - "Activation of (pro)renin receptor (PRR) is involved in the progression of chronic kidney disease. "
12/01/2013 - "Serum level of soluble (pro)renin receptor is modulated in chronic kidney disease."
04/01/2019 - "(Pro)renin Receptor Blockade Ameliorates Heart Failure Caused by Chronic Kidney Disease."
10/01/2021 - "Silencing of Central (Pro)renin Receptor Ameliorates Salt-Induced Renal Injury in Chronic Kidney Disease."

12/01/2011 - "Moreover, novel targets have been identified in RAAS, such as the (pro)renin receptor, and molecules, which counteract the classical actions of Ang II and are therefore beneficial in cardiovascular diseases. "
04/01/2011 - "Recent studies have revealed that (pro)renin receptor ((P)RR), a newly identified member of the renin-angiotensin system, is associated with organ damage that occurs with cardiovascular disease. "
01/01/2023 - "The role of (pro)renin receptor and its soluble form in cardiovascular diseases."
01/01/2021 - "The (pro)renin receptor (PRR) is an important member of the local tissue renin-angiotensin system and plays a vital role in many cardiovascular diseases. "
11/01/2019 - "(Pro)renin receptor (PRR), a novel member of the renin-angiotensin system, participates in various cardiovascular diseases. "

06/01/2008 - "Recent in vivo studies have demonstrated that the overexpression of the (pro)renin receptor to a degree similar to that observed in hypertensive rat kidneys leads to slowly progressive nephropathy with proteinuria. "
12/31/2023 - "Both compounds reduced kidney injury, proteinuria, and inhibited the (pro)renin receptor (PRR)-renin-angiotensin system (RAS) pathway, inflammatory cell infiltration, oxidative stress, and fibrosis. "
12/01/2011 - "Here, podocyte-specific, conditional, prorenin receptor-knockout mice died of kidney failure and severe proteinuria within 4 weeks of birth. "
09/01/2007 - "Therefore, prorenin-receptor blockers, which competitively bind to the receptor as a decoy peptide, have superior benefits with regard to proteinuria and glomerulosclerosis in experimental animal models with elevated plasma prorenin levels such as diabetes and hypertension compared with conventional RAS inhibitors, possibly by inhibiting both the nonproteolytic activation of prorenin and RAS-independent intracellular signals."
06/01/2007 - "In vivo infusion of the (pro)renin receptor blocker peptide (formerly handle region decoy peptide) significantly inhibited the development of glomerulosclerosis, proteinuria, MAPK activation, and TGF-beta1 expression in the kidneys, but the angiotensin-converting enzyme inhibitor did not attenuate these changes despite a significant decrease in the renal AngII level. "

01/01/2022 - "This research aimed to examine the role of (pro)renin receptor (PRR) in DOX-induced heart failure (HF) and its underlying mechanism. "
01/01/2020 - "Soluble (pro)renin receptor in elderly chronic heart failure patients."
10/09/2013 - "Increased plasma soluble (pro)renin receptor levels are correlated with renal dysfunction in patients with heart failure."
09/01/2012 - "The (pro)renin receptor (P)RR is implicated in blood pressure regulation and the pathophysiology of heart failure (HF). "
09/01/2012 - "Hemodynamic, hormonal, and renal effects of (pro)renin receptor blockade in experimental heart failure."