Proximal Femoral Fractures

Fractures of the proximal FEMUR at the HIP.

Also Known As:

Femoral Fracture, Proximal; Femur Fracture, Proximal; Fracture, Proximal Femoral; Fracture, Proximal Femur; Fractures, Proximal Femoral; Proximal Femoral Fracture; Proximal Femur Fracture; Femoral Fractures, Proximal; Femur Fractures, Proximal; Proximal Femur Fractures

Networked: 489 relevant articles (28 outcomes, 67 trials/studies)

Relationship Network

Disease Context: Research Results

Wounds and Injuries: 176426

Related Diseases

1.	Pain (Aches)
2.	Osteoporosis
3.	Proximal Femoral Fractures
4.	Bone Cysts (Bone Cyst)
5.	Wounds and Injuries (Trauma)

Experts

1.	Parker, M J: 7 articles (11/2006 - 01/2001)
2.	Giannoudis, Peter V: 6 articles (05/2022 - 08/2016)
3.	Egol, Kenneth A: 5 articles (01/2020 - 01/2008)
4.	Edel, Melanie: 3 articles (01/2022 - 01/2020)
5.	Möbius, Robert: 3 articles (01/2022 - 01/2020)
6.	Zajonz, Dirk: 3 articles (01/2022 - 01/2020)
7.	Knobe, Matthias: 3 articles (01/2022 - 12/2020)
8.	Freitas, Anderson: 3 articles (07/2019 - 01/2017)
9.	Ruffing, T: 3 articles (11/2016 - 09/2013)
10.	Kammerlander, C: 3 articles (12/2015 - 11/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Proximal Femoral Fractures:

1.	ElementsIBA 01/01/2017 - "The strain data is very useful for identifying fracture initiation within the femur, and for eventual validation of proximal femur fracture strength models derived from Quantitative Computed Tomography-based Finite Element Analysis (QCT/FEA)." 04/01/2001 - "Improved prediction of proximal femoral fracture load using nonlinear finite element models." 01/01/2020 - "This study aimed to evaluate bone strength of the proximal femur with or without hip OA and proximal femoral fracture risk using computed tomography (CT)-based finite element analysis (FEA). " 11/01/2019 - "This study models all combinations of a range of implant variables for nine standard AO/OTA proximal femur fractures using finite element analysis. " 10/01/2014 - "Multiple loading conditions analysis can improve the association between finite element bone strength estimates and proximal femur fractures: a preliminary study in elderly women."
2.	Tranexamic Acid (AMCA)FDA Link 02/01/2023 - "Tranexamic acid is effective in reducing blood loss and transfusion rates, without increasing the risk of thromboembolic events after proximal femoral fractures. " 02/01/2023 - "The aim of our study was to investigate the use of tranexamic acid in patients with proximal femoral fractures and compare the total blood loss, transfusion rates, complications, and the application method. " 02/01/2023 - "Does tranexamic acid reliably reduce blood loss in proximal femur fracture surgery?"
3.	Opioid Analgesics (Opioids)IBA 01/01/2022 - "A total of 166 patients with hip and proximal femur fractures from August 12, 2018 to April 25, 2021; 81 received FICB plus systemic opioids, and 85 received only systemic opioids. " 01/01/2022 - "FICB is a safe and effective preoperative technique for initial pain management in patients with hip and proximal femur fractures, as it can also be used with additional systemic opioids. " 01/01/2022 - "To demonstrate that administering FICB preoperatively to patients with hip or proximal femur fractures in the emergency department (ED) is likely to reduce opioid use and related complications, and to decrease hospital length of stay (LOS). " 10/25/2021 - "Perioperative PCB in elderly patients with a proximal femur fracture could be an effective analgesia technique, as it decrease the number of patients with severe pain, need for on demand analgesia and opioid consumption. " 08/01/2020 - "Delirium is a common complication after proximal femoral fracture surgery, with pain and opioid consumption as the contributing factors. "
4.	Dalteparin (Dalteparin Sodium)FDA Link 02/01/2023 - "Both dalteparin and reviparin are safe and effective agents for thromboprophylaxis in patients with proximal femur fractures."
5.	SuspensionsIBA 01/01/2020 - "Sixty patients with proximal femur fractures were randomized into two groups: a balanced suspension group and a pillow group. " 01/01/2020 - "Balanced Suspension versus Pillow on Preoperative Pain for Proximal Femur Fractures: A Randomized Controlled Trial." 01/01/2020 - "To evaluate the efficacy of a balanced suspension system, using the Thomas splint, with Pearson attachment, compared with a pillow for preoperative pain in patients with proximal femoral fractures. "
6.	Calcifediol (Calcidiol)FDA Link 11/01/2000 - "As there is little evidence of the efficacy of 25-hydroxyvitamin D3 (25-HCC) in reducing the risk of new fractures in osteoporotic women, we performed an open, prospective study with a follow-up of 1 yr in 58 females over 65 yr of age with osteoporosis and proximal femoral fractures. "
7.	reviparin (reviparin-sodium)IBA 02/01/2023 - "Both dalteparin and reviparin are safe and effective agents for thromboprophylaxis in patients with proximal femur fractures."
8.	Polymethyl Methacrylate (Sol)IBA 12/04/2018 - "The objective of this study was to evaluate, by means of a static flexural test, the biomechanical parameters necessary for the occurrence of a proximal femoral fracture in a synthetic bone model after the removal of a dynamic hip screw (DHS) and comparing the results obtained with a reinforcement technique using polymethylmethacrylate (PMMA). " 01/01/2017 - "To evaluate, through biomechanical testing, the resistance to and energy required for the occurrence of proximal femoral fracture in synthetic bone after removal of a proximal femoral nail model (PFN), comparing the results obtained with a reinforcement technique using polymethylmethacrylate (PMMA). " 02/01/2012 - "Implant augmentation with small amounts of PMMA enhances the cut-out resistance in proximal femoral fractures. " 04/01/2021 - "The proximal femoral fractures were stabilized with implantation of the PFNA or Gamma nail and augmentation was performed with two different cements: polymethylmethacrylate (PMMA) in 4 studies and calcium phosphate (CP) in one study. " 07/01/2019 - "Objective This study aims to evaluate, through biomechanical tests, the resistance and energy required for proximal femoral fracture in synthetic bones after removing cannulated screws shaped as an inverted triangle, comparing the obtained results to those of a reinforcement technique with polymethylmethacrylate (PMMA) as bone cement. "
9.	Bupivacaine (Bupivacaine Hydrochloride)FDA LinkGeneric 11/01/2015 - "Determination of the minimum initial intrathecal dose of isobaric 0.5% bupivacaine for the surgical repair of a proximal femoral fracture: A prospective, observational trial." 03/01/2000 - "This prospective randomized study was designed to determine the hemodynamic effects and quality of combined lumbar and sacral plexus block compared with plain bupivacaine spinal anesthesia in the elderly for repair of proximal femoral fractures. " 01/01/2022 - "An unblinded study of adult patients with hip and proximal femur fractures who consented to receive an FICB with 30 cc of bupivacaine with epinephrine administered in the ED. "
10.	Diphosphonates (Bisphosphonates)IBA 11/01/2022 - "We included randomized controlled trials examining fracture healing and union rates in adults with proximal femoral fractures undergoing osteosynthesis fixation methods and administered bisphosphonates within 1 month of operation with a control group. " 01/01/2017 - "However, in six studies, the mean age of patients with bisphosphonate-related AFFs is younger than those with typical proximal femoral fractures (mean age range of 66-75 years versus 75-89 years respectively). " 12/02/2018 - "A Case Series and Discussion on Surgical Treatment Strategy for Atypical Proximal Femoral Fractures Associated with Bisphosphonate Use." 06/01/2017 - "Patients may be at an increased risk of atypical proximal femoral fractures with prolonged bisphosphonate use. " 06/01/2017 - "Retrospective review of patients with atypical bisphosphonate related proximal femoral fractures."

Therapies and Procedures

1.	Arthroplasty 10/01/2013 - "But there are good results for arthroplasty after proximal femoral fractures in younger active patients as well, when the fracture was not recognized or treated immediately. " 01/01/2014 - "The aim of the study was to investigate the efficacy of greater trochanteric fixation using a multifilament cable to ensure abductor lever arm continuity in patients with a proximal femoral fracture undergoing partial hip arthroplasty. " 01/01/2019 - "Conversion hip arthroplasty reliably provides improved quality of life and immediate weight bearing, making it an effective treatment for salvage of failed fixation of pathologic proximal femur fractures." 10/01/2004 - "Hip arthroplasty is an effective treatment for salvage of failed treatment of pathologic proximal femoral fractures. " 03/01/2016 - "The aim of this study was to analyze in-hospital mortality in proximal femoral fracture patients operatively treated with hip arthroplasty procedure. "
2.	Analgesia 01/01/2022 - "The aim of this study is to compare the efficacy of ultrasound-guided transmuscular (anterior) quadratus lumborum block (QLB) versus infrainguinal fascia iliaca compartment block (FICB) in proximal femur fractures for postoperative analgesia. " 10/01/2015 - "To ascertain the efficacy of fascia iliaca block for providing analgesia for adults with proximal femoral fractures when compared with standard management. " 10/01/2014 - "to determine the efficacy of the fascia iliaca block in providing analgesia to patients with a proximal femoral fracture in the emergency department. " 10/25/2021 - "Psoas compartment block efficacy and safety for perioperative analgesia in the elderly with proximal femur fractures: a randomized controlled study." 10/01/2023 - "PENG block provides better analgesia than a femoral block before spinal anaesthesia for proximal femur fracture surgery. "
3.	Intramedullary Fracture Fixation 03/01/2012 - "LISS can be used effectively in treating proximal femoral fractures, especially for complex fractures patterns in which intramedullary nailing may be difficult. " 11/01/2022 - "The purpose of this study was to compare patients with proximal femur fractures undergoing antegrade versus retrograde intramedullary nailing (AIMN vs RIMN) and determine the safety and efficacy of RIMN. " 12/01/2019 - "The aim of this study is to evaluate the results of elastic stable intramedullary nailing (ESIN) of extra-articular proximal femur fractures in children and adolescents. " 01/01/2023 - "Retrograde intramedullary nailing can be an effective treatment strategy for extremely proximal femur fractures when necessary. " 01/01/2023 - "To report the results of retrograde intramedullary nailing (RIMN) for the treatment of extremely proximal femur fractures. "
4.	Spinal Anesthesia 04/01/2020 - "The aim of this study was to compare the overall efficacy of the two blocks in patients with proximal femur fracture before positioning for spinal anesthesia. " 04/01/2020 - "Comparison of preoperative ultrasound guided fascia iliaca block versus femoral nerve block for proximal femur fractures before positioning for spinal anesthesia: an observational study." 01/01/2022 - "[Spinal anesthesia vs. general anesthesia for surgical stabilization of proximal femoral fractures : The REGAIN trial in context]." 03/01/2018 - "Comparative Study for Evaluating Efficacy of Fascia Iliaca Compartment Block for Alleviating Pain of Positioning for Spinal Anesthesia in Patients with Hip and Proximal Femur Fractures." 03/01/2000 - "This prospective randomized study was designed to determine the hemodynamic effects and quality of combined lumbar and sacral plexus block compared with plain bupivacaine spinal anesthesia in the elderly for repair of proximal femoral fractures. "
5.	Traction 01/01/2002 - "We performed a prospective randomised trial to evaluate the efficacy of pre-operative skin traction for proximal femoral fractures in 311 patients. " 01/01/2018 - "The objective of this study is to assess the clinical utility of internal rotation traction radiography in the classification of proximal femoral fractures. " 05/01/2023 - "The research question was: which are the effects of skin traction, its advantages and disadvantages in adult patients with proximal femur fractures hospitalised in orthopaedic wards? " 05/01/2023 - "The use of skin traction in the adult patients with proximal femur fracture. " 08/27/2021 - "Conclusion: In this pilot study, the application of traction does not affect skin and subcutaneous microcirculation in the surgery of proximal femur fractures."