Bromodomain Containing Proteins

Non-histone chromosomal proteins that regulate GENE EXPRESSION through a variety of mechanisms including recognizing acetylated HISTONE LYSINE residues and through transcriptional machinery regulation.

Also Known As:

Containing Protein, BRDs; Containing Proteins, Bromodomain; Protein, BRDs Containing; Proteins, Bromodomain Containing; Proteins, Bromodomain-Containing; BRDs Containing Protein; Bromodomain-Containing Proteins

Networked: 38 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843

Experts

1.	Prinjha, Rab K: 3 articles (07/2018 - 10/2014)
2.	Boyson, Samuel P: 2 articles (07/2021 - 01/2020)
3.	Glass, Karen C: 2 articles (07/2021 - 01/2020)
4.	Barton, Michelle C: 2 articles (01/2017 - 02/2016)
5.	Kang, Nianqian: 1 article (06/2022)
6.	Wang, Lifei: 1 article (06/2022)
7.	Wang, Yan: 1 article (06/2022)
8.	Yang, Zhiyong: 1 article (06/2022)
9.	Yu, Yingxia: 1 article (06/2022)
10.	Zhao, Juan: 1 article (06/2022)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2024 - "In this study, we used the cancer genome atlas (TCGA) dataset to analyze the expression of bromodomain-containing proteins in HCC, as bromodomains are emerging attractive therapeutic targets. " 06/01/2022 - "Bromodomain-containing proteins 7 and 9 (BRD7 and BRD9) have been considered as potential targets of clinical drug design toward treatment of human cancers and other diseases. " 01/01/2021 - "Additionally, our integrated genomics and interactome profiling in prostate tumor show that YY1 and bromodomain-containing proteins (BRD2/4) co-occupy a majority of gene-regulatory elements, coactivating downstream targets. " 08/01/2019 - "In this sense, bromodomain-containing proteins have emerged as potential epigenetic targets in cancer research and other therapeutic areas. " 11/01/2017 - "Members of the BET family of bromodomain containing proteins have been identified as potential targets for blocking proliferation in a variety of cancer cell lines. "
2.	Infections 04/01/2021 - "SARS-CoV-2 proteins physically associate with many different host proteins over the course of infection, and notably there are several interactions between viral proteins and epigenetic enzymes such as HDACs and bromodomain-containing proteins as shown by correlation-based studies. "
3.	Inflammation (Inflammations) 06/02/2014 - "Pharmacological inhibition of bromodomain-containing proteins in inflammation." 10/09/2014 - "Through their function as epigenetic readers of the histone code, the BET family of bromodomain-containing proteins regulate expression of multiple genes of therapeutic relevance, including those involved in tumor cell growth and inflammation. " 03/01/2014 - "This has led to major strides in the understanding of the function of bromodomain-containing proteins and their involvement in diseases such as cancer and inflammation. " 12/12/2019 - "The Bromodomain and Extra-Terminal motif (BET) proteins, Bromodomain-containing protein (Brd) 2 (Brd2), Brd3 and Brd4 regulate inflammation in non-gestational tissues. " 05/03/2020 - "Emerging evidences indicate bromodomain-containing proteins 2 and 4 (BRD2 and BRD4) play critical roles in cancers, inflammations, cardiovascular diseases and other pathologies. "
4.	Genetic Translocation (Chromosomal Translocation) 03/01/2016 - "Chromosomal translocations of bromodomain-containing proteins have been implicated in many diseases. " 07/19/2021 - "Dysregulated gene expression, chromosomal translocations, and/or mutations in bromodomain-containing proteins have been correlated with poor patient outcomes in cancer. "
5.	Cardiovascular Diseases (Cardiovascular Disease) 05/03/2020 - "Emerging evidences indicate bromodomain-containing proteins 2 and 4 (BRD2 and BRD4) play critical roles in cancers, inflammations, cardiovascular diseases and other pathologies. " 11/15/2017 - "The BET family of bromodomain-containing proteins (BRDs) is believed to be a promising drug target for therapeutic intervention in a number of diseases including cancer, inflammation and cardiovascular diseases. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Viral Proteins
3.	Enzymes
4.	Lysine (L-Lysine)
5.	Histone Deacetylase Inhibitors
6.	Apoptosis Regulatory Proteins
7.	Protein Isoforms (Isoforms)
8.	Transcription Factors (Transcription Factor)
9.	Peptides (Polypeptides)
10.	Nuclear Proteins (Protein, Nuclear)

Related Therapies and Procedures

1.	Therapeutics