Calcinosis Cutis

Pathological deposition of calcium in the skin and subcutaneous tissue. Excessive calcification of the skin may be associated with underlying diseases that cause tissue damage (e.g., EHLERS-DANLOS SYNDROME; PSEUDOXANTHOMA ELASTICUM; ROTHMUND-THOMSON SYNDROME; and WERNER SYNDROME) or that cause abnormal calcium and phosphate metabolism (e.g., CALCIPHYLAXIS; CHRONIC KIDNEY FAILURE; HYPERPARATHYROIDISM; and SARCOIDOSIS).

Also Known As:

Networked: 299 relevant articles (11 outcomes, 13 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Systemic Scleroderma (Systemic Sclerosis)
2.	Calcinosis
3.	Shock
4.	Pain (Aches)
5.	Interstitial Lung Diseases (Interstitial Lung Disease)

Experts

1.	Cohen, Philip R: 4 articles (09/2021 - 12/2012)
2.	Chung, Lorinda: 3 articles (02/2022 - 11/2015)
3.	Valenzuela, Antonia: 3 articles (02/2022 - 11/2015)
4.	Marie, Isabelle: 3 articles (10/2013 - 02/2009)
5.	Callen, Jeffrey P: 3 articles (06/2012 - 04/2008)
6.	Calame, Antoanella: 2 articles (09/2021 - 01/2021)
7.	Uebelhoer, Nathan S: 2 articles (09/2021 - 01/2021)
8.	Smith, Gideon P: 2 articles (11/2020 - 09/2013)
9.	Lin, Shan-Yang: 2 articles (03/2014 - 11/2005)
10.	Dominique, Stéphane: 2 articles (10/2013 - 06/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Calcinosis Cutis:

1.	Diltiazem (Cardizem)FDA LinkGeneric 09/01/2017 - "Idiopathic Calcinosis Cutis Universalis Treated Successfully with Oral Diltiazem-A Case Report." 05/01/2010 - "We emphasize the fact that the presence of calcinosis cutis has not been described previously in patients with SS, and that diltiazem has partially improved our patient's cutaneous lesions." 09/01/2017 - "We successfully treated a case of idiopathic calcinosis cutis using oral diltiazem." 04/01/2014 - "Diltiazem is recommended by some authors as first-line approach in calcinosis cutis and is also the therapeutic principal referred by the largest number of available publications. " 01/01/2023 - "This case report also highlighted the importance of diltiazem in the treatment of calcinosis cutis which is more commonly seen in patients with dermatomyositis."
2.	sodium thiosulfateFDA Link 12/01/2020 - "Efficacy of intralesional sodium thiosulfate for the treatment of dystrophic calcinosis cutis: A double-blind, placebo-controlled pilot study." 12/01/2022 - "Clinical and ultrasonography follow-up of five cases of calcinosis cutis successfully treated with intralesional sodium thiosulfate." 01/01/2022 - "Topical sodium thiosulfate as treatment of calcinosis cutis: Case series and systematic review." 10/01/2020 - "Topical sodium thiosulfate: a reliable treatment for digital calcinosis cutis - a case series with six patients." 08/01/2020 - "Dystrophic calcinosis cutis: treatment with intravenous sodium thiosulfate."
3.	Calcium Gluconate (CBG)IBA 08/06/2023 - "Data of neonates diagnosed with iatrogenic calcinosis cutis caused by calcium gluconate exudation between December 2012 and June 2021 were analyzed retrospectively. " 08/06/2023 - "Neonatal iatrogenic calcinosis cutis caused by calcium gluconate extravasation." 11/01/2021 - "A rare case report of neonatal calcinosis cutis induced by distant and delayed extravasation of intravenous calcium gluconate." 08/13/2020 - "Severe Iatrogenic Calcinosis Cutis From Extravasated Calcium Gluconate." 08/01/2010 - "Although iatrogenic calcinosis cutis is generally a benign entity, the early recognition of the presentation of extravasation of calcium gluconate is important to avoid severe complications and possible medical malpractice disputes. "
4.	Diphosphonates (Bisphosphonates)IBA 02/26/2021 - "These results provide further evidence that bisphosphonates can be used successfully to treat calcinosis cutis in pediatric rheumatologic disorders. " 11/16/2021 - "Bisphosphonates for the Treatment of Calcinosis Cutis-A Retrospective Single-Center Study." 11/16/2021 - "(4) Conclusions: Bisphosphonates appear to have beneficial effects in a subgroup of calcinosis cutis patients. " 01/01/2013 - "Dystrophic Cutaneous Calcification and Metaplastic Bone Formation due to Long Term Bisphosphonate Use in Breast Cancer." 11/16/2021 - "(2) Methods: In this retrospective analysis we evaluate the effects of intravenous pamidronate, a second-generation bisphosphonate, in seven patients with calcinosis cutis using consecutive clinical pictures, radiological examinations and patient's subjective evaluation. "
5.	Triamcinolone Acetonide (Azmacort)FDA LinkGeneric 03/01/1997 - "The efficacy of treatment with triamcinolone acetonide in calcinosis cutis following extravasation of calcium gluconate: a preliminary study." 03/01/1997 - "This experiment was designed to evaluate the efficacy and safety of treatment with triamcinolone acetonide in calcinosis cutis following extravasation of calcium gluconate. " 03/01/1997 - "We suggest that intralesional injection of triamcinolone acetonide for the treatment of calcinosis cutis following extravasation of calcium gluconate is effective, probably due to its antiinflammatory effect and its role in facilitating the resorption of calcium in the tissue."
6.	sodium metabisulfite (sodium pyrosulfite)IBA 12/01/2017 - "Clinical and radiological improvement in idiopathic calcinosis cutis with topical 25% sodium metabisulfite." 09/01/2016 - "Topical sodium metabisulfite is a promising emerging therapy that should be considered as a valid alternative treatment in calcinosis cutis. " 09/01/2016 - "Topical sodium metabisulfite for the treatment of calcinosis cutis: a promising new therapy." 09/01/2016 - "Four women diagnosed with calcinosis cutis, secondary to dermatomyositis, systemic sclerosis and radiodermatitis after breast cancer, were evaluated for their response to topical 25% sodium metabisulfite. " 05/01/2023 - "Traumatic dystrophic calcinosis cutis in a child successfully treated with sodium metabisulfite ointment."
7.	Minocycline (Cyclops)FDA LinkGeneric 03/01/2012 - "Although there is no uniformly effective treatment for calcinosis cutis, several surgical and medical therapies have demonstrated varying degrees of benefit in the treatment of calcinosis, including surgical excision, laser therapy, extracorporeal shock wave lithotripsy, diltiazem, minocycline, colchicine, and topical sodium thiosulfate, along with others. "
8.	ColchicineFDA LinkGeneric 03/01/2012 - "Although there is no uniformly effective treatment for calcinosis cutis, several surgical and medical therapies have demonstrated varying degrees of benefit in the treatment of calcinosis, including surgical excision, laser therapy, extracorporeal shock wave lithotripsy, diltiazem, minocycline, colchicine, and topical sodium thiosulfate, along with others. "
9.	CalciumIBA 11/01/2005 - "The findings of this study could explain why canine HAC may cause clinical signs such as calcinosis cutis that are associated with altered calcium metabolism." 11/03/2023 - "Iatrogenic calcinosis cutis may be seen as a complication of the infusion of calcium-containing fluids via intraosseous access, in addition to the more commonly observed peripheral intravenous access. " 10/12/2023 - "Histologically demonstrated calcium deposition within the dermis and subcutaneous tissue consistent with calcinosis cutis. " 10/11/2023 - "Calcinosis cutis is the deposition of insoluble calcium in the skin and subcutaneous tissues. " 10/06/2023 - "Subepidermal calcified nodules are benign entities that can be seen in the head and neck region and are part of a family of calcifying disorders known as calcinosis cutis, in which calcium is deposited in subcutaneous tissue. "
10.	SaltsIBA 11/01/2020 - "Calcinosis cutis is the aberrant deposition of insoluble calcified salts in cutaneous tissue that occurs in association with a variety of diseases. " 03/11/2014 - "Calcinosis cutis (CC) is a type of calcinosis wherein insoluble compounds or salts deposited on the skin. " 11/01/2022 - "The common cutaneous findings were sclerodactyly (86.7%), stellate scars (78.3%), parrot-beaked nose (76.7%), mask-like facies (75%), microstomia (56.7%), salt and pepper pigmentation (55%), puffy finger (46.7%), telangiectasia (46.7%), digital ulcer (38.3%), fixed flexion deformity (33.3%), and calcinosis cutis (8.33%). " 01/01/2023 - "Calcinosis cutis is characterized by the deposition of calcium salts in the skin and subcutaneous tissue. " 12/01/2022 - "Calcinosis cutis (CC) is characterized by deposit of calcium salts in the skin and subcutaneous tissue; its clinical presentation consists of indurated painful nodules, which can ulcerate and become superinfected. "

Therapies and Procedures

1.	Therapeutics 09/01/1999 - "The calcinosis cutis resolved completely in all three dogs with no (two cases) or only palliative (one case) therapy." 06/01/2022 - "Calcinosis cutis is challenging to treat with no gold standard therapy. " 08/01/2022 - "Local, non-systemic, and minimally invasive therapies for calcinosis cutis: a systematic review." 01/01/2018 - "We report three patients with long-standing and extensive CTD-associated calcinosis cutis treated with IV STS after having failed multiple prior therapies. " 02/01/2016 - "Our patient was 54-year-old lady, a case of limited cutaneous scleroderma with widespread progressive calcinosis cutis unresponsive to current therapy. "
2.	Extracorporeal Shockwave Therapy 09/01/2016 - "The aim of this prospective, controlled, monocentric study was to assess safety and efficacy of extracorporeal shock wave therapy (ESWT) for calcinosis cutis of the finger in SSc patients. " 05/25/2015 - "[Calcinosis cutis treatment with extracorporeal shockwave therapy]." 09/01/2016 - "Safety and efficacy of extracorporeal shock wave therapy (ESWT) in calcinosis cutis associated with systemic sclerosis."
3.	Lithotripsy (Extracorporeal Shockwave Lithotripsy) 12/01/2021 - "Dystrophic calcinosis cutis successfully treated with extracorporeal shockwave lithotripsy." 03/01/2012 - "Treatment of calcinosis cutis by extracorporeal shock-wave lithotripsy." 03/01/2015 - "Effectiveness of extracorporeal shock wave lithotripsy to treat dystrophic calcinosis cutis ulcers." 04/01/2005 - "Electric shock wave lithotripsy (ESWL) as a pain control measure in dermatomyositis with calcinosis cutis-old method, new discovery." 04/01/2005 - "A 23-year-old Chinese man with dermatomyositis associated calcinosis cutis received electric shock wave lithotripsy (ESWL) as an alternate to a conventional pharmacological regimen to reduce pain associated with the complications of subcutaneous calcinosis nodules. "
4.	Gas Lasers 01/01/2020 - "CO2 laser seems to be a valuable tool to treat milia-like calcinosis cutis lesions." 06/01/2014 - "A dystrophic calcinosis cutis case treated with CO2 laser." 01/01/2020 - "To describe the treatment of Milia-like idiopathic calcinosis cutis of the forehead in an adult without Down's syndrome successfully treated with a CO2 laser. " 01/01/2020 - "Here, we describe the successful use of a CO2 laser in the treatment of milia-like calcinosis cutis of the forehead in an adult without Down's syndrome. " 01/01/2020 - "Milia-like idiopathic calcinosis cutis of the forehead in an adult without Down's syndrome successfully treated with a CO2 laser."
5.	Laser Therapy (Surgery, Laser) 12/01/2020 - "Seven weeks following the cystoscopic laser ablation of the ectopic ureter and resolution of the urinary incontinence, the calcinosis cutis lesions completely resolved without any specific treatment. " 03/01/2012 - "Although there is no uniformly effective treatment for calcinosis cutis, several surgical and medical therapies have demonstrated varying degrees of benefit in the treatment of calcinosis, including surgical excision, laser therapy, extracorporeal shock wave lithotripsy, diltiazem, minocycline, colchicine, and topical sodium thiosulfate, along with others. "