Weight Cycling

01/01/2016 - "Serum organochlorine levels may be affected not only by age, but also factors related to lipid turnover (i.e., episodes of weight cycling and WHR), and warrants further study."
12/01/1999 - "The effect of weight cycling on blood lipids and blood pressure in the Multiple Risk Factor Intervention Trial Special Intervention Group."
11/15/2023 - "Together, these data suggest that weight cycling may induce a unique population of mast cells similar to lipid associated macrophages. "
02/01/2015 - "There is even evidence for an increased ability of fat storage in subcutaneous fat depots (at the trunk in men and at the limbs in women) with weight cycling that may provide a certain protection from ectopic lipid deposition and thus explain the preservation of a favourable metabolic profile despite weight regain. "
05/01/2007 - "Cardiovascular risk factors including lipid profile and blood pressure were not adversely affected by weight cycling. "

11/01/2022 - "Instead, weight cycling reduces insulin secretory capacity in vivo during clamped hyperglycemia and ex vivo in perifused islets. "
11/01/2022 - "Weight Cycling Impairs Pancreatic Insulin Secretion but Does Not Perturb Whole-Body Insulin Action in Mice With Diet-Induced Obesity."
11/01/1997 - "Present findings suggest that weight cycling in rats increases risk of breast cancer development via insulin stimulated mammary cell proliferation."
12/30/2017 - "Many experimental studies support that weight cycling might cause fluctuations in cardiovascular risk factors, such as blood pressure, heart rate, sympathetic activity, and circulating levels of glucose, lipids and insulin. "
02/01/2015 - "In addition, findings from studies of experimental weight cycling have reinforced the notion that fluctuations of cardiovascular risk variables (such as blood pressure, heart rate, sympathetic activity, blood glucose, lipids and insulin) with probable repeated overshoots above normal values during periods of weight regain put an additional stress on the cardiovascular system. "

11/01/2022 - "Thus, we aimed to pinpoint the main regulatory junctions at which weight cycling alters glucose homeostasis in mice. "
11/01/2022 - "The mechanisms responsible for weight cycling-induced deterioration in glucose homeostasis are poorly understood. "
01/01/2022 - "This innate immune memory response may contribute to worsened glucose tolerance following weight cycling."
10/01/2014 - "Weight cycling (defined as number of 5-lb [2.25-kg] weight cycles) ranged 0-6 times per participant and was positively associated with incident diabetes (HR 1.33, 95% CI 1.12, 1.58; P < 0.01), fasting glucose (β = 0.91 mg/dL per cycle; P = 0.02), HOMA-IR (β = 0.25 units per cycle; P = 0.04), and systolic blood pressure (β = 0.94 mmHg per cycle; P = 0.01). "
09/01/2013 - "Weight cycling increases T-cell accumulation in adipose tissue and impairs systemic glucose tolerance."

11/01/2000 - "Weight cycling and high-density lipoprotein cholesterol in women: evidence of an adverse effect: a report from the NHLBI-sponsored WISE study. "
03/01/1996 - "As the present study was conducted on a small population, interaction between weight cycling and smoking status on HDL cholesterol should be confirmed using a larger population."
11/01/2000 - "Reported weight cycling was associated with 7% lower high-density lipoprotein cholesterol (HDL-C) levels in women (p = 0.01). "
03/01/1996 - "Our results showed the effects of weight cycling on changes in coronary risk factors only for HDL cholesterol based on analysis by smoking status. "
01/01/2018 - "Despite an adverse association with HDL-cholesterol in women undergoing coronary angiography for suspected ischemia, weight cycling was associated with a lower adverse outcome rate in women with suspected ischemia."

03/01/1996 - "This study examined the relationship between weight cycling during ages 21 to 35 and changes in coronary risk factors (systolic blood pressure, diastolic blood pressure, total cholesterol, and HDL cholesterol) during ages 35 to 40. "
09/01/2000 - "Most importantly, the weight cycling led to an overshoot or fluctuation of serum cholesterol, triglyceride, glucose, insulin, and glucagon. "
09/01/2000 - "The present study investigated the effect of weight cycling on the size and fatty acid composition of rat fat pads as well as serum cholesterol, triglyceride, glucose, insulin, and glucagon in rats. "

01/01/2018 - "At baseline, women with a weight cycling history had lower HDL-C values, higher body mass index, larger waist circumferences and higher values for fasting blood sugar, but no difference in obstructive CAD prevalence or severity. "
01/01/2020 - "Here, we report that weight cycling induced by alternating feeding mice with a low-fat diet or a high-fat diet in a 1-week switch protocol caused further increased epididymal white adipose tissue (eWAT) weight, preadipocyte proliferation, hepatic inflammation, fasting blood glucose level, and glucose intolerance, compared with the continuously HF-fed mice. "
12/01/2006 - "Moreover, fluctuations in blood pressure, heart rate, sympathetic activity, glomerular filtration rate, blood glucose and lipids that may occur during weight cycling--with overshoots above normal values during weight regain periods--put an additional load on the cardiovascular system, and may be easily overlooked if humans or animals are studied during a state of relatively stable weight. "
02/01/2015 - "In addition, findings from studies of experimental weight cycling have reinforced the notion that fluctuations of cardiovascular risk variables (such as blood pressure, heart rate, sympathetic activity, blood glucose, lipids and insulin) with probable repeated overshoots above normal values during periods of weight regain put an additional stress on the cardiovascular system. "
11/01/1998 - "The general principles of the nutritional management of type 2 diabetes are: (1) Dietary recommendations for patients with diabetes should be similar to those for the general population; (2) Dietary recommendations should be flexible and highly individualized for the patient and his or her family; (3) Table sugar or foods containing sugar do not need to be restricted to a level less than in a typical American diet; (4) Readily digestible starches raise the blood glucose more than sugars; (5) The effects of weight loss on glycemic control will occur within 2 or 3 months, after which more definitive therapies should be instituted; and (6) Patients should not be stigmatized for failing to lose weight, and weight cycling should be discouraged. "

01/01/1997 - "We conclude that weight cycling changes the ratio of polyunsaturated fatty acids to saturated fatty acids and remodels the adipose tissue triacylglycerol species profile in rats."
10/20/2017 - "A history of weight cycling did not result in increased BW or fat mass compared with the control group, nor in deteriorated serum concentrations of glucose, adipokines and serum triglyceride and free fatty acid (FFA) concentrations. "
01/01/2004 - "Body composition and fat distribution (by bioelectrical impedance analysis and anthropometry), systolic and diastolic blood pressure, plasma glucose, total and HDL cholesterol, triglycerides, insulin and insulin resistance by HOMAir, various weight cycling indices. "
09/01/2000 - "Most importantly, the weight cycling led to an overshoot or fluctuation of serum cholesterol, triglyceride, glucose, insulin, and glucagon. "
09/01/2000 - "The present study investigated the effect of weight cycling on the size and fatty acid composition of rat fat pads as well as serum cholesterol, triglyceride, glucose, insulin, and glucagon in rats. "

10/01/2020 - "In addition to causing fluctuations in the physiological parameters, the weight cycling led to increases of adipocyte number and serum fatty acids. "
09/01/2000 - "It is concluded that weight cycling in rats may promote body fatness if an HF diet is consumed and can significantly alter whole body fatty acid balance irrespective of whether they consumed an MF or HF diet. "
09/01/2000 - "Weight cycling-induced alteration in fatty acid metabolism."
12/01/2006 - "Potential mechanisms by which weight cycling contributes to cardiovascular morbidity include hypertension, visceral fat accumulation, changes in adipose tissue fatty acid composition, insulin resistance and dyslipidemia. "
01/01/1997 - "We conclude that weight cycling changes the ratio of polyunsaturated fatty acids to saturated fatty acids and remodels the adipose tissue triacylglycerol species profile in rats."

01/01/1997 - "Depletion of linoleate induced by weight cycling is independent of extent of calorie restriction."
01/01/1997 - "The objective of the present study was to test the hypothesis that the weight cycling-induced reduction in linoleate and alpha-linolenate is independent of extent of calorie restriction. "
04/01/1996 - "Thus, whole-body depletion of linoleate and alpha-linolenate did not occur per se but the partitioning of linoleate and alpha-linolenate was significantly altered by weight-cycling resulting in lower whole-body accumulation and higher apparent oxidation of all polyunsaturates especially linoleate and alpha-linolenate."
04/01/1996 - "Our hypothesis was that repeated fasting-refeeding or weight-cycling would increase the beta-oxidation of linoleate and alpha-linolenate thereby depleting their whole-body levels. "
02/01/1995 - "We conclude that, despite providing adequate n-6 and n-3 polyunsaturates in the diet during the refeeding period, weight cycling in young growing rats causes a moderate, selective depletion of linoleate and alpha-linolenate from tissue stores."

01/01/1997 - "The objective of the present study was to test the hypothesis that the weight cycling-induced reduction in linoleate and alpha-linolenate is independent of extent of calorie restriction. "
04/01/1996 - "Thus, whole-body depletion of linoleate and alpha-linolenate did not occur per se but the partitioning of linoleate and alpha-linolenate was significantly altered by weight-cycling resulting in lower whole-body accumulation and higher apparent oxidation of all polyunsaturates especially linoleate and alpha-linolenate."
04/01/1996 - "Our hypothesis was that repeated fasting-refeeding or weight-cycling would increase the beta-oxidation of linoleate and alpha-linolenate thereby depleting their whole-body levels. "
02/01/1995 - "We conclude that, despite providing adequate n-6 and n-3 polyunsaturates in the diet during the refeeding period, weight cycling in young growing rats causes a moderate, selective depletion of linoleate and alpha-linolenate from tissue stores."

09/01/2002 - "Intervals of caloric restriction/refeeding resulting in weight-cycling were protective against MT development in this mouse model. "
12/24/2022 - "Given the mixed results and the potential for severe caloric restriction to lead to weight cycling, future studies are needed to clarify how caloric restriction affects sleep and the potential implications for weight-management efforts."
01/01/2005 - "In this study, the authors examined biomedical consequences of participation in a professionally delivered, multifaceted very low calorie diet (VLCD) program and whether the degree of benefit associated with treatment was moderated by history of weight cycling. "
09/01/2002 - "In the present study, the consequence of intermittent caloric restriction/refeeding resulting in weight-cycling was evaluated using an oncogene-induced MT mouse model. "
10/01/2020 - "In the WF group, weight cycling was performed two times, using 21 days of ad libitum commercial feed and 21 days of caloric restriction with 40% of the feed consumed by the OVX group. "

11/01/2007 - "Overall, obese bariatric surgery candidates were accurate in self-report of weight, although the degree of accuracy differed by race and weight cycling history."
11/01/2007 - "Accuracy of self-reported weight among bariatric surgery candidates: the influence of race and weight cycling."
11/01/2019 - "We qualitatively summarized studies related to intentional weight loss and weight cycling due to the inconsistent definition, and quantitatively summarized studies when bariatric surgery was the mechanism of intentional weight loss. "
11/01/2019 - "A total of 127 full-text articles were reviewed, and 13 were included (bariatric surgery n=7, self-reported intentional weight loss n=2, self-reported weight cycling n=4). "
11/01/2019 - "We summarized the literature on intentional weight loss, weight cycling after intentional weight loss, bariatric surgery, and endometrial cancer risk. "

01/01/2019 - "Conventional psychopharmacologic therapy must be reassessed under the aspects of weight cycling and development of central obesity as a deterioration factor for a worse clinical course leading to early cardiovascular events in BPD subgroups."
01/01/2015 - "We refer to the former as "presumptions" and the latter as "myths." Here, we present nine myths and 10 presumptions surrounding the effects of rapid weight loss; setting realistic goals in weight loss therapy; stage of change or readiness to lose weight; physical education classes; breastfeeding; daily self-weighing; genetic contribution to obesity; the "Freshman 15"; food deserts; regularly eating (versus skipping) breakfast; eating close to bedtime; eating more fruits and vegetables; weight cycling (i.e., yo-yo dieting); snacking; built environment; reducing screen time in childhood obesity; portion size; participation in family mealtime; and drinking water as a means of weight loss. "
11/01/1998 - "The general principles of the nutritional management of type 2 diabetes are: (1) Dietary recommendations for patients with diabetes should be similar to those for the general population; (2) Dietary recommendations should be flexible and highly individualized for the patient and his or her family; (3) Table sugar or foods containing sugar do not need to be restricted to a level less than in a typical American diet; (4) Readily digestible starches raise the blood glucose more than sugars; (5) The effects of weight loss on glycemic control will occur within 2 or 3 months, after which more definitive therapies should be instituted; and (6) Patients should not be stigmatized for failing to lose weight, and weight cycling should be discouraged. "

05/26/1997 - "Weight cycling might be an important risk factor for premenopausal hysterectomy performed for benign conditions."
05/26/1997 - "In the incidence study, weight cycling was the only significant weight-related risk factor for hysterectomy performed for benign disease (adjusted relative risk 2.49, 95% confidence interval 1.10-5.60), explaining the relation between hysterectomy and psychological factors. "
07/01/1996 - "Weight cycling might be an important risk factor for premenopausal hysterectomy performed for benign conditions. "
07/01/1996 - "In the multivariate analysis, weight cycling was the only significant weight-related factor (relative risk 2.49, 95% CI 1.10-5.60), explaining the relation between hysterectomy and psychologic factors. "
08/01/1998 - "History of hypertension, weight cycling, and lack of education are closely related risk factors for premenopausal hysterectomy. "

05/27/2013 - "Repetitions of pre-competition weight-loss diets done by athletes participating in weight class sports can be regarded as periods of weight cycling. "
12/01/2011 - "To investigate the association between history of multiple weight loss diets followed by weight regain, namely weight cycling (WCy), and both body weight excess and abdominal fat accumulation. "