Prohibitins

Ubiquitously expressed conserved proteins associated with multiple functions including APOPTOSIS; CELL PROLIFERATION, regulations of various immune and mitochondrial functions, and cellular stress responses. Prohibitin 1 and prohibitin 2 form a ring-shaped complex in the INNER MITOCHONDRIAL MEMBRANE.

Also Known As:

Networked: 392 relevant articles (7 outcomes, 52 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Désaubry, Laurent: 10 articles (01/2021 - 03/2013)
2.	Theiss, Arianne L: 10 articles (01/2021 - 01/2007)
3.	Zhou, Tian-Biao: 10 articles (09/2014 - 01/2012)
4.	Mishra, Suresh: 9 articles (01/2019 - 01/2010)
5.	Qin, Yuan-Han: 8 articles (11/2013 - 01/2012)
6.	Thompson, Winston E: 7 articles (11/2020 - 01/2007)
7.	Cosialls, Ana M: 5 articles (09/2021 - 10/2016)
8.	Gil, Joan: 5 articles (09/2021 - 10/2016)
9.	Iglesias-Serret, Daniel: 5 articles (09/2021 - 10/2016)
10.	Núñez-Vázquez, Sonia: 5 articles (09/2021 - 10/2016)

Related Diseases

1.	Neoplasms (Cancer) 09/12/2017 - "In this study, novel evidence is provided that indicates mitochondrial prohibitins are overexpressed in hematologic tumor cells and promote cell survival under conditions of oxidative stress. " 07/01/1996 - "Our previous studies characterizing prohibitin in immortalized cells, classified into four complementation groups (A-D) based on the ability of whole-cell hybrids to become senescent, have suggested that it has tumor suppressor activity in group B cells. " 11/07/2023 - "Firstly, we found prohibitin is overexpressed in most tumors based on The Cancer Genome Atlas database, and the negative relationships between prohibitin and tumors infiltrating lymphocytes including B lymphocyte, CD4 T lymphocyte, CD8 T lymphocyte, Neutrophil, Macrophage and Dendritic, and its significant correlation with the prognosis of human cancer. " 11/07/2023 - "Exploring the expression level of prohibitin across 27 tumors based on the TGGA database by bioinformatic methods and its relationship with tumor immune infiltration. " 01/01/2023 - "Prohibitins (PHBs) are overexpressed in several types of cancers and implicated in the regulation of signaling networks that promote cell invasion and resistance to cell apoptosis. "
2.	Obesity 01/01/2018 - "Independent studies have shown improved drug efficacy by using prohibitin (PHB)-targeted therapy in obese rodents and non-human primates, thus providing a proof of concept that targeted nanotherapy can be a feasible treatment for obesity. " 01/01/2019 - "Prohibitin: a prime candidate for a pleiotropic effector that mediates sex differences in obesity, insulin resistance, and metabolic dysregulation." 06/15/2017 - "Prohibitin-induced obesity leads to anovulation and polycystic ovary in mice." 01/01/2017 - "Prohibitin - At the crossroads of obesity-linked diabetes and cancer." 04/01/2010 - "In the liver, deficient prohibitin activity participates in the progression of non-alcoholic steatohepatitis and obesity, according to mechanisms that still must be elucidated. "
3.	Colitis 05/01/2011 - "Nanoparticle-based therapeutic delivery of prohibitin to the colonic epithelial cells ameliorates acute murine colitis." 07/01/2009 - "Our previous studies showed that prohibitin (PHB) levels are decreased during colitis and that cultured intestinal epithelial cells overexpressing PHB are protected from oxidative stress. " 05/15/2013 - "Nrf2 is not required for epithelial prohibitin-dependent attenuation of experimental colitis." 11/15/2012 - "Prohibitin attenuates colitis-associated tumorigenesis in mice by modulating p53 and STAT3 apoptotic responses." 05/01/2011 - "Genetic restoration of intestinal epithelial prohibitin 1 (PHB) levels during experimental colitis reduces the severity of disease through sustained epithelial antioxidant expression and reduced NF-κB activation. "
4.	Infections 01/01/2023 - "Characterization of Plasmodium falciparum prohibitins as novel targets to block infection in humans by impairing the growth and transmission of the parasite." 01/01/2023 - "annulata infection does not affect the localization of bovine prohibitin. " 11/01/2020 - "Molecular characterization of prohibitins and their differential responses to WSSV infection in hemocyte subpopulations of Fenneropenaeus chinensis." 08/04/2020 - "As an important finding, BG95 accumulated in mitochondria visualized by anti-prohibitin and MitoTracker staining, and induced statistically significant changes of mitochondrial morphology, distinct from those induced by HCMV infection. " 11/01/2015 - "A Novel Class of Small Molecule Compounds that Inhibit Hepatitis C Virus Infection by Targeting the Prohibitin-CRaf Pathway."
5.	Inflammation (Inflammations) 12/01/2022 - "Deletion of adipocyte prohibitin 1 exacerbates high-fat diet-induced steatosis but not liver inflammation and fibrosis." 01/01/2022 - "The current findings suggest that CSE-mediated mitochondrial dysfunction, oxidative stress, cell apoptosis and inflammation in hPMECs were reduced by overexpression of prohibitin. " 08/01/2012 - "Vitamin D deficiency causes increase in the expression of TNF-α, thereby increasing inflammation and decreases the expression of VDR and prohibitin. " 08/01/2012 - "Vitamin D deficiency decreases the expression of VDR and prohibitin in the lungs of mice with allergic airway inflammation." 01/01/2022 - "Prohibitin Protects Pulmonary Microvascular Endothelial Cells Against Cigarette Smoke Extract-Induced Cell Apoptosis and Inflammation."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Heat-Shock Proteins (Heat-Shock Protein)
3.	Antioxidants
4.	Protein Disulfide-Isomerases
5.	Annexin A1
6.	Fibronectins (Fibronectin)
7.	Quercetin
8.	3' Untranslated Regions (3' UTR)
9.	Glucose (Dextrose)
10.	Tretinoin (Retinoic Acid)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Lasers (Laser)