Protocadherins

Members of cadherin superfamily involved in cell adhesion and cell-cell interactions in neural development. They are subdivided into clustered (cPcdhs) and non-clustered protocadherin (ncPcdhs) depending whether their genes are tandemly arranged in vertebrates.

Also Known As:

Cadherin Related Neuronal Receptors; Neuronal Receptors, Cadherin-Related; Non Clustered Pcdhs; Non Clustered Protocadherins; Pcdhs, Clustered; Pcdhs, Non-Clustered; Protocadherins, Clustered; Protocadherins, Non-Clustered; Receptors, Cadherin-Related Neuronal; Cadherin-Related Neuronal Receptors; Clustered Pcdhs; Clustered Protocadherins; Non-Clustered Pcdhs; Non-Clustered Protocadherins; cPcdhs; ncPcdhs

Networked: 49 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	van Roy, Frans: 3 articles (04/2022 - 12/2009)
2.	Sotomayor, Marcos: 2 articles (01/2019 - 10/2016)
3.	Cooper, Sharon R: 2 articles (10/2016 - 11/2015)
4.	Jontes, James D: 2 articles (10/2016 - 11/2015)
5.	Struhl, Gary: 2 articles (12/2015 - 06/2010)
6.	Lachman, Herbert M: 2 articles (07/2008 - 06/2008)
7.	Nolan, Karen: 2 articles (07/2008 - 06/2008)
8.	Novak, Tomas: 2 articles (07/2008 - 06/2008)
9.	Pedrosa, Erika: 2 articles (07/2008 - 06/2008)
10.	Stopkova, Pavla: 2 articles (07/2008 - 06/2008)

Related Diseases

1.	Neoplasms (Cancer) 04/25/2022 - "In view of the compelling evidence for gene silencing of protocadherins in human tumors, we started investigations on Pcdh functions in mouse cancer models. " 12/01/2020 - "Protocadherins (PCDHs) have been reported as tumor suppressor genes, implying that these genes may be involved in tumor suppression in a variety of cancers. " 05/14/2019 - "Promoter methylation of protocadherins has been suggested as a prognostic marker in different tumors, but in PDAC this epigenetic modification has not been extensively studied. " 05/14/2019 - "By bioinformatics analysis, we identified protocadherins among the most frequently mutated genes in PDAC suggesting an important role of these genes in the biology of this tumor. " 01/01/2019 - "In cancer, clustered PCDHs undergo a mechanism of long-range epigenetic silencing by hypermethylation. "
2.	Nervous System Diseases (Neurological Disorders) 12/01/2013 - "Previous studies identified that non-clustered protocadherins play significant roles in neuronal development and other implications in neurological disorders. " 01/01/2013 - "Furthermore, several δ-protocadherins have been implicated in neurological disorders and in cancers, highlighting the importance of scrutinizing their properties and their dysregulation in various pathologies." 09/29/2010 - "Non-clustered protocadherins (PCDHs) are calcium-dependent adhesion molecules which have attracted attention for their possible roles in the neuronal circuit formation during development and their implications in the neurological disorders such as autism and mental retardation. "
3.	Hematologic Neoplasms (Hematological Malignancy) 01/01/2019 - "In this study, we detected frequent methylation alterations at CpG islands associated to these clustered PCDHs in all the solid tumours analysed (colorectal, gastric and biliary tract cancers, pilocytic astrocytoma), but not hematologic neoplasms such as chronic lymphocytic leukemia. "
4.	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 01/01/2019 - "In this study, we detected frequent methylation alterations at CpG islands associated to these clustered PCDHs in all the solid tumours analysed (colorectal, gastric and biliary tract cancers, pilocytic astrocytoma), but not hematologic neoplasms such as chronic lymphocytic leukemia. "
5.	Biliary Tract Neoplasms (Biliary Tract Cancer) 01/01/2019 - "In this study, we detected frequent methylation alterations at CpG islands associated to these clustered PCDHs in all the solid tumours analysed (colorectal, gastric and biliary tract cancers, pilocytic astrocytoma), but not hematologic neoplasms such as chronic lymphocytic leukemia. "

Related Drugs and Biologics

1.	Biomarkers (Surrogate Marker)
2.	Proteins (Proteins, Gene)
3.	Cadherins (E-Cadherin)
4.	Cell Adhesion Molecules
5.	Ephrins
6.	Protein Isoforms (Isoforms)
7.	Cytokine Receptors (Cytokine Receptor)
8.	Odorant Receptors (Odorant Receptor)
9.	HLA-C Antigens (HLA-C)
10.	Tumor Biomarkers (Tumor Markers)

Related Therapies and Procedures

1.	Therapeutics
2.	Precision Medicine