Tripeptidyl-Peptidase 1
Lysosomal Serine proteases that release N-terminal tripeptide from a polypeptide and cleave peptides between hydrophobic residues. An enzyme that in humans encoded by the TPP1 gene. It is involved in the degradation of bone collagen. Mutations in this gene are associated with the CEROID LIPOFUSCINOSIS, NEURONAL, 2; and SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE CEROID LIPOFUSCINOSIS, NEURONAL, 2; AND SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 7.
Also Known As:
Peptidase I, Tripeptidyl; Protein, CLN2; Protein, TPP1; CLN2 Protein; TPP1 Protein; Tripeptidyl Aminopeptidase I; Tripeptidyl Peptidase I; Tripeptidyl Protease I; Tripeptidyl-Peptidase I
Networked: 114
relevant articles (0 outcomes,
6 trials/studies)
Bio-Agent Context: Research Results
Experts
1. | Lobel, Peter:
17 articles
(01/2020 - 10/2004)
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2. | Sleat, David E:
14 articles
(01/2020 - 10/2004)
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3. | Sohar, Istvan:
9 articles
(03/2014 - 05/2002)
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4. | Schulz, Angela:
8 articles
(01/2021 - 01/2016)
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5. | Crystal, Ronald G:
8 articles
(12/2020 - 11/2004)
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6. | Sondhi, Dolan:
8 articles
(12/2020 - 11/2004)
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7. | Hackett, Neil R:
7 articles
(12/2020 - 11/2004)
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8. | Specchio, Nicola:
5 articles
(01/2021 - 01/2016)
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9. | Kohlschütter, Alfried:
5 articles
(05/2019 - 04/2004)
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10. | Davidson, Beverly L:
5 articles
(11/2015 - 10/2004)
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