Endoplasmic Reticulum Chaperone BiP

An ENDOPLASMIC RETICULUM specific chaperone of the HSP70 family. They are involved in folding and oligomerization of secreted and membrane proteins and ENDOPLASMIC RETICULUM STRESS related UNFOLDED PROTEIN RESPONSE.

Also Known As:

BiP, Molecular Chaperone; Binding immunoglobulin Protein Molecular Chaperone; GRP78, Molecular Chaperone; Heat Shock Protein 5; Protein, HSPA5; Binding-immunoglobulin Protein Molecular Chaperone; Glucose Regulated Protein 78 kDa; Grp78; HSPA5 Protein; Heat-Shock Protein 5; Molecular Chaperone BiP; Molecular Chaperone GRP78

Networked: 1803 relevant articles (71 outcomes, 274 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Molecular Chaperones: 1279
    - Heat-Shock Proteins: 8088
      - HSP70 Heat-Shock Proteins: 1903
        Endoplasmic Reticulum Chaperone BiP: 1803
        human HSPA5 protein
        mouse Hspa5 protein
        rat GRP78 protein

Experts

1.	Lee, Amy S: 55 articles (12/2021 - 06/2004)
2.	Pizzo, Salvatore V: 22 articles (01/2021 - 11/2005)
3.	Li, Zhuoyu: 20 articles (03/2022 - 08/2012)
4.	Wang, Qi: 17 articles (01/2022 - 01/2005)
5.	Austin, Richard C: 13 articles (05/2022 - 05/2003)
6.	Cohen, Marie: 13 articles (01/2022 - 10/2011)
7.	Zhang, Lichao: 13 articles (03/2019 - 05/2013)
8.	Gonzalez-Gronow, Mario: 12 articles (05/2022 - 11/2005)
9.	Li, Zongwei: 12 articles (01/2017 - 08/2012)
10.	Chang, Yu-Jia: 12 articles (07/2015 - 02/2010)

Related Diseases

1.	Neoplasms (Cancer) 09/15/2013 - "Patients with stage II cancers treated by surgery alone, with high GRP78 also had improved survival (71% v 50%; p = 0.032). " 01/15/2008 - "Our results reveal three major mechanisms mediated by GRP78 for cancer progression: enhancement of tumor cell proliferation, protection against apoptosis, and promotion of tumor angiogenesis. " 01/01/2020 - "The ability of GRP78 to respond to endoplasmic reticulum stress (ERS) determines whether tumor cells survive and whether the changes in expression level of GRP78 regulated by endoplasmic reticulum (ER) caused by various factors will directly or indirectly affect cell proliferation, apoptosis, and injury, or reduce the body's defense ability, or have protective effects on various organs." 10/06/2017 - "Targeting UPR in both macrophage and cancer cells indicates that PERK or GRP78 reduction enhances macrophage clearance of cancer cells. " 10/01/2012 - "Up regulated GRP78 expression in tumor cells has been correlated with aggressive malignancies whereas some reports have predicted an improved prognosis. "
2.	Hypoxia (Hypoxemia) 01/01/2021 - "In this study, we aimed to explore the effects of GRP78 on hypoxia/reperfusion (H/R)-induced cardiomyocyte injury. " 01/01/2020 - "In the current study, we showed that iPSC-derived CMS neurons have increased expression of ER stress markers Grp78 and XBP1s under normoxia and hyperphosphorylation of PERK under hypoxia, alleviating ER stress does not rescue the hypoxia-induced CMS neuronal cell death. " 03/01/2012 - "In this study we describe the effect of hypoxia on astrocytes and neurons cell surface GRP78. " 04/01/1994 - "Further support for PKC in regulating GRP78 gene expression by hypoxia stems from gel-mobility shift studies in mixtures of nuclear extracts from aerobic or hypoxic cells with a 36 bp region of the GRP78 promoter (-170 to -135). " 03/01/2023 - "Hypoxia evoked significant ER stress in WAT, evidenced by increased GRP78, CHOP, and phosphorylation of IRE1α, PERK. "
3.	Prostatic Neoplasms (Prostate Cancer) 12/22/2017 - "In this study, we explore the interplay between the AutoAbs against cell surface-associated GRP78, TF expression/activity, and prostate cancer progression. " 01/01/2020 - "Shh is overexpressed in high-grade prostate cancer and is positively correlated with the expression of both GRP78 and AR. " 01/01/2020 - "Shh plays an important role in prostate cancer progression, but its correlation with GRP78 and AR is elusive. " 01/01/2020 - "Shh Overexpression Is Correlated with GRP78 and AR Expression in Primary Prostate Cancer: Clinicopathological Features and Outcomes in a Chinese Cohort." 06/06/2017 - "We found that TERS signaling induced a UPR in recipient human prostate cancer cells that included the cell surface expression of the chaperone GRP78. "
4.	Lung Neoplasms (Lung Cancer) 01/01/2022 - "Objective: This study aimed to evaluate the associations between endoplasmic reticulum (ER) stress-related genes EIF2AK3/PERK, HSPA5/GRP78, and DDIT3/CHOP polymorphisms and the risk of lung cancer. " 12/01/2021 - "This study investigated the regulation of GRP78 in tumour-associated macrophage polarization in lung cancer. " 11/12/2020 - "This study investigated the pathophysiological role of GRP78 in the survival of lung cancer cells. " 01/01/2018 - "The aim of this study is to detect the circulating level of GRP78 in the plasma of lung cancer patients and to evaluate the role of GRP78 in the early diagnosis of lung cancer. " 07/01/2005 - "The aim of this study was to detect Grp78 expression in lung cancer using immunohistochemical (IHC) staining, and also to evaluate the relationship between the Grp78 expression level and the prognosis of patients with lung cancer. "
5.	Colonic Neoplasms (Colon Cancer) 11/01/2013 - "The aim of this study was to explore the mechanism of GRP78 in two human colon cancer cell lines. " 10/01/2012 - "This study demonstrates the significance of cell surface GRP78 in colon cancer, which may be used as a marker for reduced tumorigenicity." 02/01/2011 - "Taken together, the present study provides evidences to support that GRP78 and CHOP expression, and GSK3α/β activation in mediating the MCPP-induced human colon cancer cell apoptosis." 01/01/2023 - "Positive correlation between the levels of HuR, iASPP, and GRP78 are detectable in colon cancer tissues in vivo. " 08/01/2018 - "Supplementation of p-CA downregulated Grp78 and activated UPR mediated apoptosis both in in vitro and in vivo models of colon cancer. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Glucose (Dextrose)
3.	Caspase 3 (Caspase-3)
4.	Endoplasmic Reticulum Chaperone BiP
5.	glucose-regulated proteins
6.	Messenger RNA (mRNA)
7.	Caspase 12
8.	Antibodies
9.	Transcription Factor CHOP
10.	Tunicamycin

Related Therapies and Procedures

1.	Therapeutics
2.	Radiotherapy
3.	Drug Therapy (Chemotherapy)
4.	Electroacupuncture
5.	Caloric Restriction