Decellularized Extracellular Matrix

A biomaterial with a network of macromolecules with varying composition and organization of tissue-specific proteins and polysaccharides. It is prepared from organs and tissues by decellularization (e.g., with a detergent) to mimic native microenvironment for tissue-specific functions.

Also Known As:

Networked: 86 relevant articles (2 outcomes, 16 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Cho, Dong-Woo: 3 articles (01/2021 - 01/2019)
2.	Fatherree, Jackson P: 2 articles (01/2022 - 10/2020)
3.	Guarin, Justinne R: 2 articles (01/2022 - 10/2020)
4.	McGinn, Rachel A: 2 articles (01/2022 - 10/2020)
5.	Naber, Stephen P: 2 articles (01/2022 - 10/2020)
6.	Oudin, Madeleine J: 2 articles (01/2022 - 10/2020)
7.	Hoshiba, Takashi: 2 articles (12/2021 - 04/2019)
8.	Dai, Jihang: 2 articles (01/2021 - 01/2020)
9.	Ferreira, Luís P: 2 articles (01/2021 - 12/2020)
10.	Gaspar, Vítor M: 2 articles (01/2021 - 12/2020)

Related Diseases

1.	Myocardial Infarction 01/01/2021 - "Cross-transplantation of decellularized extracellular matrix (dECM) can stimulate regeneration in myocardial infarct (MI) models. " 04/01/2021 - "A first-in-man clinical study on a myocardial-derived decellularized extracellular matrix hydrogel suggested the potential for efficacy in chronic myocardial infarction (MI) patients. " 01/18/2023 - "Injectable Decellularized Extracellular Matrix Hydrogel Containing Stromal Cell-Derived Factor 1 Promotes Transplanted Cardiomyocyte Engraftment and Functional Regeneration after Myocardial Infarction." 11/01/2023 - "Recent studies have shown promising results using decellularized ECM-derived hydrogels produced through pepsin digestion in various lung injury models and even a human clinical trial for myocardial infarction. "
2.	Lung Injury 11/01/2023 - "Recent studies have shown promising results using decellularized ECM-derived hydrogels produced through pepsin digestion in various lung injury models and even a human clinical trial for myocardial infarction. "
3.	Pancreatitis 01/01/2023 - "Combinational Treatment Involving Decellularized Extracellular Matrix Hydrogels With Mesenchymal Stem Cells Increased the Efficacy of Cell Therapy in Pancreatitis."
4.	Neoplasms (Cancer) 01/01/2022 - "This study reports a tumor model fabricated via 3D bioprinting with adipose decellularized extracellular matrix (ECM) enhanced hybrid bioink. " 01/01/2021 - "Many decellularized extracellular matrix-derived whole organs have been widely used in studies of tissue engineering and cancer models. " 01/01/2018 - "Using a combination of media conditioning experiments and decellularized extracellular matrices (ECMs), this study investigates the hypothesis that CD44v6 overexpression enhances tumor cell malignant behavior by modulating stromal cell-mediated ECM remodeling. " 07/01/2023 - "Then, a 3D culture model was generated using cryopreserved PDX tumors embedded in pre-gelled porcine skin decellularized extracellular matrix with normal human dermal fibroblasts. " 01/01/2023 - "Bioprinted cancer-stromalin-vitromodels in a decellularized ECM-based bioink exhibit progressive remodeling and maturation."
5.	Wounds and Injuries (Trauma) 12/01/2022 - "Decellularized extracellular matrix (dECM) scaffolds placed into these wounds have shown the ability to modulate the immune response and drive constructive healing. " 01/01/2022 - "However, the material properties of decellularized ECM (dECM) from in vitro cell cultures and the effect of these properties on wound remodeling remain unclear. " 01/01/2022 - "The decellularized extracellular matrices (d-ECMs) currently utilized to repair endometrial injuries are derived from three tissue sources, the endometrium (dE-ECM), placental amniotic membrane (dA-ECM), and urinary (dU-ECM). " 01/01/2019 - "Decellularized extracellular matrix microparticles seeded with bone marrow mesenchymal stromal cells for the treatment of full-thickness cutaneous wounds." 01/01/2017 - "Decellularized ECM has been suggested to be efficacious for the repair of tissue injuries. "

Related Drugs and Biologics

1.	Hydrogels
2.	Pepsin A (Pepsin)
3.	Gelatin
4.	Biocompatible Materials (Biomaterials)
5.	Alginates
6.	Cryogels
7.	Proteome
8.	Methacrylates
9.	Copper
10.	Anti-Bacterial Agents (Antibiotics)

Related Therapies and Procedures

1.	Cell- and Tissue-Based Therapy (Cell Therapy)
2.	Drug Therapy (Chemotherapy)
3.	Transplantation
4.	Injections
5.	Precision Medicine