mu-Crystallins

A subclass of crystallins expressed highly in lens of diurnal Australian MARSUPIALS and in neural tissue, muscle, and kidney in humans. It is not a structural protein accounting for the transparency of the human lens unlike other crystallins but instead plays a role in thyroid hormone bioavailability. It is also a cerebral ketimine reductase which reduces cyclic imines (e.g., DELTA(1)-PIPERIDINE-2-CARBOXYLIC ACID; CYSTATHIONINE KETIMINE and LANTHIONINE KETIMINE) in mammalian brain. Mutations in mu-crystallins are associated with an autosomal dominant NONSYNDROMIC DEAFNESS.

Also Known As:

Networked: 11 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Hashizume, Kiyoshi: 2 articles (07/2010 - 09/2007)
2.	Suzuki, Satoru: 2 articles (07/2010 - 09/2007)
3.	Hashizume, K: 2 articles (07/2009 - 06/2006)
4.	Suzuki, S: 2 articles (07/2009 - 06/2006)
5.	Jeon, Mi Yang: 1 article (05/2019)
6.	Jeon, Songhee: 1 article (05/2019)
7.	Jeong, Ha Jin: 1 article (05/2019)
8.	Kim, Ji Hyun: 1 article (05/2019)
9.	Liu, Quan Feng: 1 article (05/2019)
10.	Urnuhsaikhan, Enerelt: 1 article (05/2019)

Related Diseases

1.	Neoplasms (Cancer) 07/01/2009 - "CRYM protein was increased in cancer tissue and decreased in samples from patients after hormonal therapy. " 03/01/2002 - "Conversely, two genes that were down-regulated during tumor progression in the CWR22 model system were validated in vivo: crystallin mu (CRYM) and a LIM-domain protein LMO4 both showed significantly lower mRNA levels in hormone-refractory tumors as compared with primary tumors (P < 0.001). " 05/01/2019 - "Hippocalcin, α-spectrin, ovarian tumor domain-containing ubiquitin aldehyde-binding protein 1 (otub1), mu-crystallin, serine racemase, and rho GDP dissociation inhibitor 1, which are related to neurogenesis, neuroprotection, and synaptic strength, were upregulated in the hippocampus by moderate exercise. " 02/01/2007 - "However, aldolase C fructose-biphosphate, creatine kinase, B chain dihydrolipoyl dehydrogenase, enolase 2, fumarate hydratase, HSP60, lactoylglutathione lyase, lucine aminopeptidase, Mu-crystallin homolog, NADH-UO 24, neurofilament triplet L protein, septin 2, stathmin and vacuolar ATP synthase subunit E were downregulated in glioblastoma multiform compared with non-tumor tissues. "
2.	Deafness (Deaf Mutism) 06/01/2006 - "In a search for mutations of mu-crystallin (CRYM), a taxion specific crystalline which is also known as an NADP regulated thyroid hormone binding protein, two mutations were found at the C-terminus in patients with non-syndromic deafness. " 12/01/2017 - "The copy number variations and mutations were also used to identify single nucleotide variations (SNVs) in crystallin mu (CRYM), RAB3 GTPase activating protein catalytic subunit 1 (RAB3GAP1) and Wnt family member 10A (WNT10A), implicated in deafness, hypogonadism and tooth/skin abnormalities, respectively. "
3.	Nonsyndromic Deafness 07/01/2009 - "Patients with nonsyndromic deafness were reported to have point mutations in the mu-crystallin gene. " 09/01/2007 - "Recently, patients with nonsyndromic deafness were reported to have point mutations in the mu-crystallin gene. "
4.	Hearing Loss (Hearing Impairment) 06/01/2006 - "To investigate the mechanism of hearing loss caused by CRYM mutations T3 binding activity of mutant mu-crystallin was compared with that of wild-type mu-crystallin, because mu-crystallin is known to be identical to T3 binding protein. "
5.	Facioscapulohumeral Muscular Dystrophy 06/01/2007 - "Abnormal expression of mu-crystallin in facioscapulohumeral muscular dystrophy."

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Proteins (Proteins, Gene)
3.	Carrier Proteins (Binding Protein)
4.	mu-Crystallins
5.	rho Guanine Nucleotide Dissociation Inhibitor alpha
6.	Septins
7.	Hippocalcin
8.	Stathmin
9.	GTPase-Activating Proteins (GTPase-Activating Protein)
10.	Spectrin

Related Therapies and Procedures

1.	Therapeutics