Homeobox Protein Nkx-2.2

A homeobox-containing transcription factor that functions in INSULIN-SECRETING CELLS. Mutations in the NKX2-2 gene are associated with MATURITY-ONSET DIABETES OF THE YOUNG and OLIGODENDROGLIOMA.

Also Known As:

Homeobox Protein Nkx 2.2; Homeodomain Protein, Nkx-2.2; Nkx 2.2 Homeodomain Protein; Nkx 2.2 Protein; Protein Nkx-2.2, Homeobox; Protein, Nkx-2.2 Homeodomain; Protein, Nkx2.2; Nkx-2.2 Homeodomain Protein; Nkx-2.2 Protein; Nkx2.2 Protein

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Ding, Yipei: 1 article (02/2021)
2.	Wang, Yangyang: 1 article (02/2021)
3.	Xie, Weidong: 1 article (02/2021)
4.	Zhong, Jin: 1 article (02/2021)
5.	Hu, Yun-Hua: 1 article (11/2020)
6.	Mei, Zhi-Liang: 1 article (11/2020)
7.	Wang, Hong-Bin: 1 article (11/2020)
8.	Xiong, Li: 1 article (11/2020)

Related Diseases

1.	Inflammation (Inflammations) 02/01/2021 - "Islet cells exposed to inflammation exhibited markedly downregulated protein levels of transcription factor MafA, pancreatic and duodenal homeobox 1, paired box 6, homeobox protein Nkx-2.2, synaptosomal-associated protein 25, glucagon and insulin-2, while the expression of miR-146a-5p and miR-21a-5p were upregulated. "
2.	Hypertrophy 11/01/2020 - "Finally, our data showed that CSN6 was partially dependent on the stabilization of Nkx2.2 protein to inhibit SIRT2 and promote myocardial hypertrophy. "

Related Drugs and Biologics

1.	Sirtuin 2
2.	Synaptosomal-Associated Protein 25
3.	Transcription Factors (Transcription Factor)
4.	Proteins (Proteins, Gene)
5.	Glucagon (Glukagon)