Leucine-Rich Repeat Proteins

A protein with a three-dimensional structure that forms an alpha/beta horseshoe fold. It is found in a large number of proteins with diverse functions, including in INNATE IMMUNITY RESPONSE and NERVOUS SYSTEM.

Also Known As:

Networked: 265 relevant articles (2 outcomes, 22 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Nichols, R Jeremy: 8 articles (06/2022 - 10/2009)
2.	Newton, Alexandra C: 8 articles (01/2021 - 04/2005)
3.	Alessi, Dario R: 5 articles (01/2018 - 10/2009)
4.	Zhao, Jing: 4 articles (06/2022 - 07/2015)
5.	Gao, Tianyan: 4 articles (01/2017 - 04/2005)
6.	Huang, Chuanshu: 3 articles (01/2021 - 10/2018)
7.	Jin, Honglei: 3 articles (01/2021 - 10/2018)
8.	Kortholt, Arjan: 3 articles (01/2020 - 08/2015)
9.	Rideout, Hardy J: 3 articles (01/2019 - 01/2009)
10.	Knapp, Steven J: 3 articles (01/2018 - 08/2008)

Related Diseases

1.	Diabetic Retinopathy (Retinopathy, Diabetic) 11/22/2023 - "The lack of homology domain and leucine rich repeat protein phosphatase 2 ameliorates visual impairment in rats with diabetic retinopathy through regulation of the AKT-GSK-3β-Nrf2 signal cascade." 03/01/2010 - "This study sought to determine the distribution of opticin, an extracellular matrix small leucine-rich repeat protein secreted by the non-pigmented ciliary body epithelium (CBE), in pathological eye tissues including posterior hyaloid membranes (PHM) and epiretinal membranes (ERM) from subjects with proliferative diabetic retinopathy (PDR), central retinal vein occlusion (CRVO) and proliferative vitreoretinopathy (PVR). "
2.	Vascular Remodeling 01/01/2022 - "Pleckstrin homology domain and leucine rich repeat protein phosphatase (PHLPP) knockout mice have improved outcomes after a stroke, traumatic brain injury (TBI), and decreased maladaptive vascular remodeling following vascular injury. " 01/01/2020 - "Endothelial Scaffolding Protein ENH (Enigma Homolog Protein) Promotes PHLPP2 (Pleckstrin Homology Domain and Leucine-Rich Repeat Protein Phosphatase 2)-Mediated Dephosphorylation of AKT1 and eNOS (Endothelial NO Synthase) Promoting Vascular Remodeling."
3.	Stroke (Strokes) 01/01/2018 - "Nuclear localization leucine-rich-repeat protein 1 (NLRP1) is a cytoplasmic protein, involved in autoimmune diseases, mammalian reproduction, neuronal cell death, and stroke. " 01/01/2022 - "Pleckstrin homology domain and leucine rich repeat protein phosphatase (PHLPP) knockout mice have improved outcomes after a stroke, traumatic brain injury (TBI), and decreased maladaptive vascular remodeling following vascular injury. "
4.	Traumatic Brain Injuries (Traumatic Brain Injury) 01/01/2022 - "Pleckstrin homology domain and leucine rich repeat protein phosphatase (PHLPP) knockout mice have improved outcomes after a stroke, traumatic brain injury (TBI), and decreased maladaptive vascular remodeling following vascular injury. " 03/01/2023 - "To explore expression of histone H1 after traumatic brain injury (TBI) and the effect of the nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3) inflammasome pathway on its expression. "
5.	Vascular System Injuries 01/01/2022 - "Pleckstrin homology domain and leucine rich repeat protein phosphatase (PHLPP) knockout mice have improved outcomes after a stroke, traumatic brain injury (TBI), and decreased maladaptive vascular remodeling following vascular injury. "

Related Drugs and Biologics

1.	Phosphoric Monoester Hydrolases (Phosphatases)
2.	Nucleotides
3.	Proteins (Proteins, Gene)
4.	Phosphotransferases (Kinase)
5.	Inflammasomes
6.	Proline (L-Proline)
7.	Arginine (L-Arginine)
8.	Long Noncoding RNA
9.	Antisense RNA (Anti-Sense RNA)
10.	Nitric Oxide Synthase (NO Synthase)

Related Therapies and Procedures

1.	Therapeutics
2.	Ischemic Postconditioning