Viperin Protein

01/01/2023 - "Virus-inhibitory protein, endoplasmic reticulum-associated, interferon-inducible (Viperin) is one of the important IFN-stimulated genes (ISGs), and elicits host defense against infection. "
01/01/2019 - "Expression of the interferon-stimulated protein Viperin correlates with viral load burden in patients, and studies in mice have demonstrated its role to limit disease severity against CHIKV infection. "
06/14/2011 - "(2011) showed that the antiviral host protein viperin is co-opted to function with vMIA for facilitating infection."
01/01/2017 - "Viperin (virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible) is a widely distributed protein that is expressed in response to infection and causes antiviral effects against a broad spectrum of viruses. "
01/01/2021 - "The results showed that the transcription levels of IFNA, IFNB, and several ISGs, including myxovirus resistance (MX), interferon-induced transmembrane protein 3 (IFITM3), protein kinase R (PKR), oligoadenylate synthase (OAS), interferon-induced protein with tetratricopeptide repeats 5 (IFIT5), interferon-stimulated gene 12 (ISG12), virus inhibitory protein (VIPERIN), interferon-alpha-inducible protein 6 (IFI6), and integrin-associated protein (CD47), were upregulated in joints on days 1-7 of infection (the levels of increase of MX, IFIT5, OAS, VIPERIN, ISG12, and IFI6 were the most significant, at hundreds-fold). "

01/01/2018 - "The viperin protein is highly induced after viral infection and exhibit broad-spectrum antiviral activity. "
01/01/2013 - "The host protein viperin is an interferon stimulated gene (ISG) that is up-regulated during a number of viral infections. "
01/01/2022 - "p97-mediated degradation of the deubiquitinase USP33 results in a deficiency of Viperin protein expression during viral infection, which substantially attenuates host antiviral ability. "
06/01/2012 - "One such ISG found to be either directly induced by type I, II, and III interferons or indirectly through viral infection is the 'virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible' protein, or viperin. "
03/20/2014 - "Recent work has highlighted the importance of the host antiviral protein viperin in this process, with its ability to limit a large variety of viral infections as well as play a role in the production of type I interferon and the modulation of a number of transcription factor binding sites. "

02/01/2015 - "The effect of early viperin protein expression on RSV infection in cells that are normally permissive to RSV cultivation was examined by using either transient transfected HEp2 cells or stable transfected HeLa cells that expressed the viperin protein. "
02/01/2015 - "We examined the effect of respiratory syncytial virus (RSV) infection on viperin protein expression in the permissive HEp2 and non-permissive RAW 264.7 macrophage cell lines. "

12/15/2022 - "Here, we show that the interferon-inducible (IFN-inducible) protein viperin drove metabolic alteration in cancer cells. "
12/15/2022 - "The interferon-inducible protein viperin controls cancer metabolic reprogramming to enhance cancer progression."