A TELOMERE cap complex consisting of telomere-specific proteins in association with telomeric DNA such as telomeric dsDNA-sDNA junction. They are involved in the protection of chromosome ends and TELOMERASE regulation and play a role in CELLULAR SENESCENCE and ageing-related pathology. In general it consists of six mostly TELOMERE-BINDING PROTEINS (POT1, RAP1, TIN2, TPP1, TRF1, and TRF2).
Also Known As:
Capping Complex, Telomeric; Complex, CST; Complex, Ctc1-Stn1-Ten1; Complex, POT1-TPP1 Shelterin; Complex, Shelterin; Complex, Telomere POT1-TPP1; Complex, Telomeric Capping; Ctc1 Stn1 Ten1 Complex; POT1 TPP1 Shelterin Complex; POT1-TPP1 Complex, Telomere; Shelterin Complex, POT1-TPP1; Telomere POT1 TPP1 Complex; Telomeric Stn1 Ten1 Capping Complex; Telosomes; CST Complex; Ctc1-Stn1-Ten1 Complex; POT1-TPP1 Shelterin Complex; Telomere Cap Complex; Telomere POT1-TPP1 Complex; Telomeric Capping Complex; Telomeric Stn1-Ten1 Capping Complex; Telosome