Doublecortin-Like Kinases

A family of doublecortin domain-containing serine-threonine kinases that were originally identified in neuronal cells.

Also Known As:

Doublecortin Like Kinase 1; Doublecortin Like Kinase 2; Doublecortin Like Kinase Proteins; Doublecortin Like Kinases; Kinase Proteins, Doublecortin-Like; Kinases, Doublecortin-Like; Proteins, Doublecortin-Like Kinase; Doublecortin-Like Kinase 1; Doublecortin-Like Kinase 2; Doublecortin-Like Kinase Proteins

Networked: 99 relevant articles (1 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Houchen, Courtney W: 18 articles (12/2020 - 03/2014)
2.	Weygant, Nathaniel: 14 articles (12/2021 - 05/2014)
3.	Qu, Dongfeng: 14 articles (12/2020 - 05/2014)
4.	May, Randal: 13 articles (01/2020 - 03/2014)
5.	Chandrakesan, Parthasarathy: 12 articles (12/2020 - 05/2014)
6.	An, Guangyu: 8 articles (12/2021 - 01/2015)
7.	Sureban, Sripathi M: 8 articles (12/2019 - 05/2014)
8.	Ali, Naushad: 7 articles (01/2020 - 05/2014)
9.	Ge, Yang: 6 articles (12/2021 - 01/2016)
10.	Yao, Jiannan: 6 articles (12/2021 - 01/2017)

Related Diseases

1.	Pancreatic Neoplasms (Pancreatic Cancer) 07/23/2023 - "Objective: To explore the mechanism of Doublecortin-like kinase 1 (DCLK1) in promoting cell migration, invasion and proliferation in pancreatic cancer. " 07/23/2023 - "[Doublecortin-like kinase 1 activates Hippo pathway to promote migration, invasion and proliferation of pancreatic cancer cells]." 01/01/2023 - "In addition, we emphasized the role of tuft cells in the genesis and development of pancreatic cancers, especially the part of markers for tuft cell's doublecortin-like kinase 1 (DCLK1). " 01/22/2021 - "Doublecortin-like kinase 1 (DCLK1)-positive pancreatic cancer stem cells develop at a precancerous stage and may contribute to the lack of efficacy of pancreatic cancer therapy. " 01/01/2019 - "Doublecortin-like kinase 1 (DCLK1) is often overexpressed in pancreatic cancer, and recent studies indicate that DCLK1+ PDAC cells can initiate pancreatic tumorigenesis. "
2.	Colorectal Neoplasms (Colorectal Cancer) 06/18/2022 - "The oncogenic role of doublecortin-like kinase 1 (DCLK1) as a putative cancer stem cell (CSC) marker has been clarified in colorectal cancer (CRC). " 01/01/2020 - "Doublecortin-like kinase 1 (DCLK1) is a cancer stem cell marker for the colorectal cancer (CRC). " 01/01/2020 - "Doublecortin-like kinase 1 (DCLK1) promotes tumour proliferation in human colorectal cancer (CRC). " 12/23/2019 - "Doublecortin-like kinase 1 (DCLK1) labels tumor stem cells (TSCs) in genetic mouse models of colorectal cancer (CRC). " 02/10/2015 - "Doublecortin-like kinase 1 (DCLK1) marks TSCs in pancreatic and colorectal cancer and regulates EMT and stemness. "
3.	Carcinogenesis 01/01/2019 - "Specific stem cell marker, doublecortin-like kinase 1 (DCLK1) plays critical roles in the tumorigenesis and progression of CRC. " 01/01/2017 - "In this review, we will briefly discuss pivotal roles of the CSC marker doublecortin-like kinase 1 (DCLK1) in hepatic tumorigenesis. " 01/01/2019 - "Doublecortin-like kinase 1 (DCLK1) is often overexpressed in pancreatic cancer, and recent studies indicate that DCLK1+ PDAC cells can initiate pancreatic tumorigenesis. " 12/01/2017 - "The 5' (α)-promoter of the human doublecortin-like kinase 1 (DCLK1) gene becomes epigenetically silenced during colon carcinogenesis, resulting in loss of expression of the canonical long(L)-isoform1 (DCLK1-L) in human colon adenocarcinomas (hCRCs). " 01/01/2020 - "Doublecortin-like kinase 1 (DCLK1) is involved in tumorigenesis, tumor growth and metastasis, and epithelial-to-mesenchymal transition in many digestive tract tumors. "
4.	Colonic Neoplasms (Colon Cancer) 04/01/2013 - "Doublecortin-like kinase 1 exhibits cancer stem cell-like characteristics in a human colon cancer cell line." 12/01/2017 - "The 5' (α)-promoter of the human doublecortin-like kinase 1 (DCLK1) gene becomes epigenetically silenced during colon carcinogenesis, resulting in loss of expression of the canonical long(L)-isoform1 (DCLK1-L) in human colon adenocarcinomas (hCRCs). " 03/06/2015 - "One notable example of specific up-regulation in KRAS codon 12 mutant SW48 cells is provided by the short form of the colon cancer stem cell marker doublecortin-like Kinase 1 (DCLK1) that can be reversed by suppression of KRAS." 01/01/2015 - "Doublecortin-like kinase 1 (Dclk1), a microtubule-associated kinase, marks the fifth lineage of intestinal epithelial cells called tuft cells that function as tumor stem cells in Apc mutant models of colon cancer. " 11/01/2018 - "The aim of the present study was to explore the cytotoxic effects of 5-FU, in combination with inhibition of doublecortin-like kinase 1 (Dclk1), a tumor stem cell marker that regulates pro-survival signaling in colorectal cancer cells, in the human colon cancer cell line, COLO-320. "
5.	Breast Neoplasms (Breast Cancer) 06/01/2018 - "Our previous study has showed doublecortin like kinase 1 (DCLK1) serves as an oncogene to regulate basal-like breast cancer cell proliferation, migration and invasion, and is associated with malignant status and poor prognosis. " 06/01/2018 - "miR-424-5p regulates cell proliferation, migration and invasion by targeting doublecortin-like kinase 1 in basal-like breast cancer." 01/12/2016 - "Doublecortin-like kinase 1 expression associates with breast cancer with neuroendocrine differentiation." 04/01/2023 - "Doublecortin-like kinase 2 promotes breast cancer cell invasion and metastasis." 01/01/2019 - "Doublecortin-like kinase 1 (DCLK1) has been universally identified as a cancer stem cell (CSC) marker and is found to be overexpressed in many types of cancers including breast cancer. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Fluorouracil (Carac)
3.	Transcription Factors (Transcription Factor)
4.	Messenger RNA (mRNA)
5.	Survivin
6.	Phosphotransferases (Kinase)
7.	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)
8.	Protein Kinases (Protein Kinase)
9.	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)
10.	Biomarkers (Surrogate Marker)

Related Therapies and Procedures

1.	Therapeutics
2.	Chemoradiotherapy