Sluggish Cognitive Tempo

Defined by a constellation of caregiver-reported symptoms that includes daydreaming, difficulty initiating and sustaining effort, lethargy, and physical underactivity. These symptoms have been observed in both typically developing children and in some children with Attention-Deficit/Hyperactivity Disorder (ADHD), especially those with the predominantly inattentive presentation. (J Abnormal Child Psychology; 46: Jan 2018.127). .

Also Known As:

Networked: 17 relevant articles (2 outcomes, 6 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder)
2.	Sluggish Cognitive Tempo
3.	Dyslexia (Alexia)
4.	Bipolar Disorder (Manic Depressive Psychosis)
5.	Genetic Risk Score

Experts

1.	Becker, Stephen P: 2 articles (11/2019 - 03/2018)
2.	McBurnett, Keith: 2 articles (01/2017 - 11/2013)
3.	Wietecha, Linda: 2 articles (01/2017 - 11/2013)
4.	Williams, David: 2 articles (01/2017 - 11/2013)
5.	Chen, Chaomei: 1 article (01/2022)
6.	Cortese, Samuele: 1 article (01/2022)
7.	Perroud, Nader: 1 article (01/2022)
8.	Sabé, Michel: 1 article (01/2022)
9.	Solmi, Marco: 1 article (01/2022)
10.	Blanco, Estela: 1 article (06/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Sluggish Cognitive Tempo:

1.	Methylphenidate (Ritalin)FDA LinkGeneric 01/01/2021 - "Objective: This study investigated the effects of sluggish cognitive tempo (SCT), other psychiatric symptoms, age, dose, and pretreatment ADHD severity on methylphenidate (MPH) treatment response among ADHD children in both home and school. " 01/01/2021 - "An Open-Label Trial of Methylphenidate Treating Sluggish Cognitive Tempo, Inattention, and Hyperactivity/Impulsivity Symptoms Among 6- to 12-Year-Old ADHD Children: What Are the Predictors of Treatment Response at Home and School?" 08/01/2009 - "In this naturalistic study, we assessed the effect of sluggish cognitive tempo (SCT) symptoms in the response to methylphenidate (MPH) in 88 children and adolescents with attention-deficit/hyperactivity disorder-Inattentive Type (ADHD-I) according to Diagnostic and Statistical Manual of Mental Disorders, 4(th) edition (DSM-IV) criteria. " 03/01/2018 - "To examine whether sluggish cognitive tempo (SCT) symptomatology moderates dose response to methylphenidate and whether the impact of SCT on medication response is distinct from attention-deficit/hyperactivity disorder (ADHD) subtype effects. " 03/01/2018 - "Sluggish Cognitive Tempo as a Possible Predictor of Methylphenidate Response in Children With ADHD: A Randomized Controlled Trial."
2.	Atomoxetine Hydrochloride (Strattera)FDA LinkGeneric 10/01/2014 - "Could atomoxetine improve sluggish cognitive tempo symptoms?" 01/01/2017 - "Atomoxetine-Related Change in Sluggish Cognitive Tempo Is Partially Independent of Change in Attention-Deficit/Hyperactivity Disorder Inattentive Symptoms." 11/01/2013 - "The purpose of this study was to evaluate atomoxetine treatment effects in attention-deficit/hyperactivity disorder (ADHD-only), attention-deficit/hyperactivity disorder with comorbid dyslexia (ADHD+D), or dyslexia only on ADHD core symptoms and on sluggish cognitive tempo (SCT), working memory, life performance, and self-concept. " 01/01/2017 - "Least squares mean changes from baseline to endpoint for atomoxetine versus placebo on the Kiddie-Sluggish Cognitive Tempo Interview (K-SCT) (Parent, Teacher, and Youth) were analyzed using analysis of covariance and multiple regression (partial R2) analyses to test contributions of ADHD and dyslexia to improvements in K-SCT scores. " 01/01/2017 - "To evaluate effects of atomoxetine versus placebo on sluggish cognitive tempo (SCT) and determine factors affecting improvement of SCT in children with attention-deficit/hyperactivity disorder (ADHD) with dyslexia (ADHD+D) or dyslexia only. "
3.	Lisdexamfetamine DimesylateFDA Link 01/01/2021 - "Objective: To examine the efficacy of lisdexamfetamine (LDX) versus placebo on behavioral attributes of sluggish cognitive tempo (SCT) in adults with attention-deficit/hyperactivity disorder (ADHD) and SCT. " 01/01/2021 - "A Placebo-Controlled Trial of Lisdexamfetamine in the Treatment of Comorbid Sluggish Cognitive Tempo and Adult ADHD."
4.	TEMPOIBA 01/01/2023 - "Lee «SCT» (sluggish cognitive tempo) scale to assess manifestations of low cognitive tempo, the «Random Access Memory» method to quantify working memory, the TOVA (The Test of Variables of Attention) computer test to quantify assessment of attention disorders and impulsivity level, electroencephalogram (routine and spectral analysis) (p<0.05). " 11/01/2019 - "Despite the moniker "sluggish cognitive tempo," the evidence is mixed regarding the extent to which it is associated globally with slowed (sluggish) mental (cognitive) information processing speed (tempo). " 01/01/2014 - "A systematic review of empirical studies on SCT in ADHD and other pathologies in PsycInfo, SocIndex, Web of Science and PubMed using the key terms "Sluggish Cognitive Tempo", "Cognitive Tempo", "Sluggish Tempo" was performed. "
5.	Immunoglobulin D (IgD)IBA 08/01/2023 - "The purpose of this study was to examine the relationships between Attention Deficit Hyperactivity Disorder (ADHD), Sluggish Cognitive Tempo (SCT), demographic factors, and Internet Addiction (IA) and internet gaming disorder (IGD) among medical students and resident doctors. "
6.	A-factor (Streptomyces)IBA 01/01/2020 - "Background: Childhood adversity has been suggested, but not yet empirically examined, as a factor in sluggish cognitive tempo (SCT) in childhood.Objective" 05/01/2004 - "The inclusion of sluggish cognitive tempo items markedly changed ADHD symptom associations for boys and girls in a factor analytic framework. "
7.	NicotineFDA Link 01/01/2023 - "An Examination of the Role of Sluggish Cognitive Tempo as a Moderator of the Relationship Between ADHD and Nicotine Use."
8.	IronIBA 06/01/2021 - "Iron status was assessed at ages 6, 12, and 18 months, and verbal intelligence, inattention, and sluggish cognitive tempo (SCT) symptoms were assessed at age 10. "
9.	Tricyclic Antidepressive Agents (Tricyclic Antidepressants)IBA 01/01/2022 - "In chronological order, identified clusters of themes included: tricyclic antidepressants, ADHD diagnosis/treatment, bipolar disorder, EEG, polymorphisms, sleep, executive functions, pharmacology, genetics, environmental risk factors, emotional dysregulation, neuroimaging, non-pharmacological interventions, default mode network, Tourette, polygenic risk score, sluggish cognitive tempo, evidence-synthesis, toxins/chemicals, psychoneuroimmunology, Covid-19, and physical exercise. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 02/01/2021 - "Although there is no proven evidence regarding pharmacotherapy of Sluggish Cognitive Tempo (SCT), we experienced atomoxetine had more effects in decreasing SCT symptoms after switching from methylphenidate in a case with SCT and subthreshold ADHD."