Prolyl Oligopeptidases

A family of serine proteases with specificity for proline-specific cleavage of peptides that are not longer than 30 amino acids. In humans it is broadly distributed in all tissues with higher activity found in the brain.

Also Known As:

Endopeptidase I, Prolyl; Endopeptidase, Post-Proline; Endopeptidase, Proline Specific; Oligopeptidases, Prolyl; Post Proline Cleaving Enzyme; Post Proline Endopeptidase; Post-Proline Cleaving Enzyme; Post-Proline Endopeptidase; Proline Endopeptidase; Proline Specific Endopeptidase; Prolyl Endopeptidase; Prolyl Endopeptidase (Thiol-dependent); Prolyl Endopeptidase I; Prolyl Oligopeptidase

Networked: 200 relevant articles (6 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Endopeptidases: 633
        Serine Endopeptidases: 11
        Prolyl Oligopeptidases: 200
        Trypanosoma cruzi Tc80 prolyl oligopeptidase: 1
        human PREPL protein

Experts

1.	Myöhänen, Timo T: 10 articles (10/2021 - 09/2012)
2.	García-Horsman, J Arturo: 8 articles (01/2017 - 06/2007)
3.	Männistö, Pekka T: 7 articles (01/2017 - 12/2006)
4.	Zolotov, N N: 6 articles (09/2020 - 11/2006)
5.	Lambeir, Anne-Marie: 6 articles (08/2020 - 07/2011)
6.	Khlebnikova, N N: 6 articles (01/2019 - 11/2006)
7.	Krupina, N A: 6 articles (01/2019 - 11/2006)
8.	Campolo, Michela: 5 articles (11/2021 - 12/2020)
9.	Casili, Giovanna: 5 articles (11/2021 - 12/2020)
10.	Esposito, Emanuela: 5 articles (11/2021 - 12/2020)

Related Diseases

1.	Celiac Disease (Celiac Sprue) 09/01/2005 - "No genetic association of the human prolyl endopeptidase gene in the Dutch celiac disease population." 12/20/2005 - "Fermentation, purification, formulation, and pharmacological evaluation of a prolyl endopeptidase from Myxococcus xanthus: implications for Celiac Sprue therapy." 09/01/2005 - "Oral administration of a bacterial prolyl-endopeptidase (PEP) therefore was proposed as a treatment for celiac disease. " 03/01/2003 - "[Oral administration of prolyl-endopeptidase: a rational treatment for celiac disease?]." 01/01/2019 - "Development of wheat genotypes expressing a glutamine-specific endoprotease from barley and a prolyl endopeptidase from Flavobacterium meningosepticum or Pyrococcus furiosus as a potential remedy to celiac disease."
2.	Schizophrenia (Dementia Praecox) 01/01/2017 - "The prolyl oligopeptidase inhibitor IPR19 ameliorates cognitive deficits in mouse models of schizophrenia." 03/23/2023 - "Prolyl Oligopeptidase (POP) inhibition is an emerging strategy for compensating cognitive deficits in hypoglutamatergic states such as schizophrenia, although little is known about how POP inhibitors exert their pharmacological activity. " 03/23/2023 - "Inhibition of Prolyl Oligopeptidase Restores Prohibitin 2 Levels in Psychosis Models: Relationship to Cognitive Deficits in Schizophrenia." 07/09/2010 - "Prolyl endopeptidase (PEP) cleaves neuropeptides and is a drug target for neuropsychiatric diseases such as post-traumatic stress disorder, depression, and schizophrenia. " 07/13/2009 - "Here we describe the design, synthesis and evaluation of the first solid-phase substrates for prolyl oligopeptidase (POP), a cytosolic serine peptidase associated with schizophrenia, bipolar affective disorder and related neuropsychiatric disorders. "
3.	Ischemia 11/02/2021 - "The Protective Role of Prolyl Oligopeptidase (POP) Inhibition in Kidney Injury Induced by Renal Ischemia-Reperfusion." 09/29/2021 - "Prolyl endopeptidase (PREP), involved in inflammatory responses, could be targeted for recovery from the permanent consequences following intestinal ischemia. " 09/29/2021 - "Inhibition of Prolyl Oligopeptidase Prevents Consequences of Reperfusion following Intestinal Ischemia." 08/17/2021 - "The protective role of prolyl oligopeptidase (POP) inhibition in acute lung injury induced by intestinal ischemia-reperfusion." 10/01/1989 - "A potent prolyl endopeptidase inhibitor, Z-thiopro-thiazolidine, and 2 novel pyrrolidone derivatives, p-chlorobenzyl-2-pyrrolidone-5-carboxylate and N-(2-pyridylmethyl)-2-pyrrolidone-5-carboxamide, improved the acquisition of the passive avoidance response in the ischemia-induced amnesic models."
4.	Inborn Genetic Diseases (Disease, Hereditary) 06/01/2012 - "Altered prolyl oligopeptidase (PREP) activity is found in many common neurological and other genetic disorders, and in some cases PREP inhibition may be a promising treatment. "
5.	Pulmonary Fibrosis (Fibrosing Alveolitis) 08/25/2023 - "Prolyl oligopeptidase inhibition ameliorates experimental pulmonary fibrosis both in vivo and in vitro." 08/25/2023 - "In this context, recent scientific research has identified new molecules involved in angiogenesis and inflammation, such as the prolyl oligopeptidase (PREP), a proteolytic enzyme belonging to the serine protease family, linked to the pathology of many lung diseases such as pulmonary fibrosis. "

Related Drugs and Biologics

1.	Enzymes
2.	Peptides (Polypeptides)
3.	Glutens (Glutelin)
4.	Antipsychotic Agents (Antipsychotics)
5.	Pyrrolidinones (Pyrrolidones)
6.	Cysteine (L-Cysteine)
7.	Z-thioPro-thiazolidine
8.	Peptide Hydrolases (Proteases)
9.	Proline (L-Proline)
10.	Prolyl Oligopeptidases

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Oral Administration
4.	Chemoprevention
5.	Surgical Instruments (Clip)