Viral Proteases

A broad category of proteolytic enzymes that are produced by VIRUSES. They play a role in the viral life cycle by processing viral proteins and possibly acting on host cell proteins.

Also Known As:

Networked: 35 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Luo, Honglin: 2 articles (01/2021 - 01/2018)
2.	Ahmad, Varish: 1 article (10/2022)
3.	Alharbi, Ali H: 1 article (10/2022)
4.	Sajid Jamal, Qazi Mohammad: 1 article (10/2022)
5.	Arkona, Christoph: 1 article (12/2021)
6.	Bartenschlager, Ralf: 1 article (12/2021)
7.	Bergemann, Silke: 1 article (12/2021)
8.	Demirel, Peter: 1 article (12/2021)
9.	Fischer, Christina: 1 article (12/2021)
10.	Kallis, Stephanie: 1 article (12/2021)

Related Diseases

1.	Infections 04/15/2017 - "This study provides new tools for evaluating the host cell response to RV infections in real time and suggests that differential 2Apro activities explain, in part, strain-dependent host responses and diverse RV disease phenotypes.IMPORTANCE Genetic variation among human rhinovirus types includes unexpected diversity in the genes encoding viral proteases (2Apro) that help these viruses achieve antihost responses. " 01/01/2022 - "3CLpro and PLpro are two important viral proteases responsible for proteolysis, infection, and replication of the virus. " 03/01/2002 - "At times when cap-dependent translation is first blocked during infection, only 25 to 35% of the total cellular PABP is cleaved; therefore, we hypothesized that the pool of PABP associated with polysomes may be preferentially targeted by viral proteases. " 11/18/2021 - "6. Regulation of apoptosis: Enteroviruses prevent apoptosis during early stages of infection and promote cell death during later stages by using the viral proteases 2A and 3C, and viroporin 2B. " 01/01/2021 - "Successful antiviral regimens for the treatment of human immunodeficiency virus and hepatitis C virus infections have established viral proteases as validated targets for antiviral drug development. "
2.	Virus Diseases (Viral Diseases) 08/29/2022 - "Thus, SG extracts and the active ingredients could potentially be used to prevent/treat viral infections, including SARS-CoV-2, due to their dual-inhibition functions against viral proteases." 01/01/2019 - "Many viral proteases also cleave host factors to facilitate virus infection. " 01/01/2018 - "In this mini-review, we give an overview of plant viral proteases emphasizing their importance during viral infections and the varied functionalities that result from their proteolytic activities." 01/01/2023 - "Viral proteases play a crucial role in viral infection and are regarded as promising targets for antiviral drug development. " 01/01/2023 - "This study provides a new approach to analyzing viral proteases and holds the potential for developing direct-acting antivirals and novel therapies for viral infections."
3.	COVID-19 02/08/2022 - "These results from our work would provide informative rationales to design a practical and noninvasive alternative for COVID-19 diagnostic testing-the presence of viral proteases in biofluids is validated." 01/01/2021 - "Viral Proteases as Targets for Coronavirus Disease 2019 Drug Development." 01/01/2021 - "Targeting SARS-CoV-2 viral proteases as a therapeutic strategy to treat COVID-19." 11/06/2020 - "In this Review, we discuss how host and viral proteases participated in the pathogenesis of COVID-19 as well as the prospects and ongoing clinical trials of protease inhibitors as treatments." 10/01/2022 - "Thus, significant docking interaction and stable dynamicity of Doxo-protease complex with time was suggested that Doxo could be a choice to inhibit potentially the viral proteases that could prevent the entry inside the host cell to control the COVID-19 disease. "
4.	Neoplasms (Cancer) 12/13/2007 - "Ovarian tumor domain-containing viral proteases evade ubiquitin- and ISG15-dependent innate immune responses." 05/01/2004 - "This study serves as a template for design of recombinant proteins to enhance and control apoptosis of tumor cells via specific viral proteases and for use of viral proteases as in vivo reporters for cancer therapy." 12/13/2007 - "In this issue of Cell Host & Microbe, Frias-Staheli and colleagues demonstrate that research on viral proteases of certain nairoviruses and arteriviruses reveals the presence of ovarian tumor domain-containing sequences that act as general deubiquitinases and deISGylases and increase viral replication by inhibiting the antiviral response mediated by ISG15." 01/01/2016 - "Viral ovarian tumor domain proteases (vOTUs) are one of the two principal classes of viral proteases observed to reverse posttranslational modification of host proteins by ubiquitin and interferon-stimulated gene product 15 (ISG15), subsequently facilitating downregulation of IFN-I signaling pathways. "
5.	Bites and Stings (Sting) 01/01/2023 - "Overall, our study highlights a multifaceted and effective strategy by which an RNA virus antagonizes cGAS-STING signaling which may be useful for the design of antivirals targeting viral proteases." 11/16/2020 - "Our data suggest widespread 2'3'-cGAMP signaling in insect antiviral immunity and explain how a family of cGAS-STING evasion enzymes evolved from viral proteases through gain of secondary nuclease activity. "

Related Drugs and Biologics

1.	Antiviral Agents (Antivirals)
2.	Peptide Hydrolases (Proteases)
3.	Papain
4.	RNA (Ribonucleic Acid)
5.	Protease Inhibitors (Protease Inhibitor)
6.	Cysteine Proteases (Cysteine Protease)
7.	Recombinant Proteins
8.	Proteins (Proteins, Gene)
9.	Polyproteins
10.	Enzymes

Related Therapies and Procedures

1.	Therapeutics