Cardiac Papillary Fibroelastoma

Primary tumors, predominantly of the CARDIAC VALVES, characterized by multiple papillary frond structures. Although histologically benign, they may result in complications (e.g., valve dysfunction, EMBOLISM; STROKE; and SUDDEN DEATH).

Also Known As:

Networked: 55 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Disease Progression
2.	Brain Ischemia (Cerebral Ischemia)
3.	Neoplasms (Cancer)
4.	Myxoma (Myxomas)
5.	Stroke (Strokes)

Experts

1.	Alonso, Nieves: 2 articles (07/2014 - 09/2013)
2.	Balboa, Oscar: 2 articles (07/2014 - 09/2013)
3.	Clavera, Belén: 2 articles (07/2014 - 09/2013)
4.	Galiana, Alberto: 2 articles (07/2014 - 09/2013)
5.	Magadán, Víctor: 2 articles (07/2014 - 09/2013)
6.	Redondo-Robles, Laura: 2 articles (07/2014 - 09/2013)
7.	Tejada, Javier: 2 articles (07/2014 - 09/2013)
8.	Hoshino, Satoshi: 1 article (12/2021)
9.	Itakura, Ryosuke: 1 article (12/2021)
10.	Ito, Toshiaki: 1 article (12/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cardiac Papillary Fibroelastoma:

1.	AnticoagulantsIBA 12/01/2021 - "Lung ventilation/perfusion scintigraphy shows the efficacy of anticoagulant therapy and surgical treatment for papillary fibroelastoma originating from the tricuspid valve." 04/25/1998 - "The growing number of reports of surgery for papillary fibroelastomas of the heart led us to evaluate the diagnostic potential of ultrasonography in patients with cerebral or coronary signs and to assess the efficacy of anticoagulant therapy in preventing recurrent cerebral ischemia and disease progression after resection. "
2.	A 7 (A-7)IBA 01/01/2003 - "The patient underwent a left ventriculotomy and excision of a.7 cm friable mass, which was later identified as a papillary fibroelastoma (PFE) by routine histopathologic studies. "
3.	Warfarin (Coumadin)FDA LinkGeneric 08/26/2020 - "We present an unusual case of cardiac papillary fibroelastoma originating from the coumadin ridge (CR) in a 70-year-old woman. " 08/26/2020 - "Cardiac papillary fibroelastoma originating from the coumadin ridge and review of literature." 06/01/2019 - "Surgical exploration revealed a papillary fibroelastoma originating from the coumadin ridge, which is fairly rare but important as a source of cerebral embolization." 10/01/2017 - "A Large Cardiac Papillary Fibroelastoma Arising from the Coumadin Ridge: Unusual Location and Presentation." 01/01/2017 - "Papillary fibroelastoma arising from the coumadin ridge."
4.	Calbindin 2IBA 11/01/2000 - "Calretinin expression was identified in 100% of CMs and was negative in all cases of mural thrombi, jaw myxoma, and papillary fibroelastoma. "
5.	Antiphospholipid AntibodiesIBA 04/01/1994 - "[Emboligenic mitral papillary fibroelastoma and positive antiphospholipid antibodies]." 04/01/1994 - "Cardiac papillary fibroelastoma has been associated to high levels of antiphospholipid antibodies, either primary or in the context of systemic lupus erythematosus. "
6.	Rubber (Elastica)IBA 01/01/2016 - "We diagnosed this condition as papillary fibroelastoma based upon the pathological findings with hematoxylin and eosin staining, and Elastica van Gieson staining. "
7.	Hematoxylin (Haematoxylon)IBA 01/01/2016 - "We diagnosed this condition as papillary fibroelastoma based upon the pathological findings with hematoxylin and eosin staining, and Elastica van Gieson staining. "
8.	Eosine Yellowish-(YS) (Eosin)IBA 01/01/2016 - "We diagnosed this condition as papillary fibroelastoma based upon the pathological findings with hematoxylin and eosin staining, and Elastica van Gieson staining. "
9.	AntibodiesIBA 10/20/2023 - "Immunohistochemical examination with antibodies against spike SARS-CoV-2 was performed on 21 heart tumors: 10 myxomas operated before 2020 (the control group), four cardiac myxomas, one proliferating myxoma, three papillary fibroelastomas, two myxofibrosarcomas, one chondrosarcoma resected in 2022-2023. "
10.	Amyloid (Amyloid Fibrils)IBA 08/01/2021 - "Role of imaging for diagnosis and management of aortic valve papillary fibroelastoma and cardiac amyloid light chain amyloidosis: a case report."

Therapies and Procedures

1.	Therapeutics 08/01/2021 - "A papillary fibroelastoma of the aortic valve with intermittent obstruction of the coronary arteries requires surgical therapy. " 04/01/2017 - "We report a case of effective anticoagulation therapy prior to surgical excision of an aortic valve papillary fibroelastoma. " 04/01/2017 - "[Effective Anticoagulation Therapy Prior to Surgical Excision of an Aortic Valve Papillary Fibroelastoma Diagnosed after a Transient Cerebral Ischemic Attack;Report of a Case]." 04/01/2016 - "<Learning objective: Primary surgical excision is the recommended therapy for symptomatic cardiac papillary fibroelastoma. " 04/01/2016 - "Primary surgical excision is the recommended therapy for symptomatic cardiac papillary fibroelastoma. "
2.	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 01/01/2018 - "In this report, we present a case of papillary fibroelastoma which was found incidentally before coronary artery bypass grafting operation and successful removal of the lesion with a valve sparing approach." 01/01/2005 - "One was an 82-year-old woman with a left ventricular papillary fibroelastoma, who underwent previous coronary artery bypass grafting. " 06/01/1994 - "The incidental finding of a small pedunculated papillary fibroelastoma arising from the atrial septum detected by transesophageal two-dimensional echocardiography (TEE) in a patient undergoing coronary artery bypass grafting is reported. " 11/01/1993 - "Transesophageal echocardiographic localization of an aortic valve papillary fibroelastoma during routine coronary artery bypass surgery."
3.	Thoracotomy 02/28/2020 - "The Right Anterior Thoracotomy Approach to Resect a Cardiac Papillary Fibroelastoma of the Aortic Valve." 10/01/2018 - "[Excision of a Left Ventricular Papillary Fibroelastoma via Right Thoracotomy with a Small Skin Incision]." 08/01/2018 - "This includes a description of how robotic assistance was gradually integrated during right mini-thoracotomy aortic valve replacement, a series of cases in which the robot was docked for parts of the procedure, a single case of a totally endoscopic robot-assisted aortic valve replacement with a stentless valve, and three cases of aortic valve papillary fibroelastoma resections. "
4.	Endovascular Procedures 07/01/2014 - "Mechanical endovascular procedure for the treatment of acute ischemic stroke caused by total detachment of a papillary fibroelastoma." 09/02/2013 - "Mechanical endovascular procedure for the treatment of acute ischemic stroke caused by total detachment of a papillary fibroelastoma."
5.	Sternotomy 11/13/2023 - "These cases involved heart valve papillary fibroelastomas located in two common sites: the aortic valve on the left heart, which was accessed via an upper hemi-sternotomy, and the tricuspid valve on the right heart, which was accessed via beating heart total thoracoscopy. " 12/01/2006 - "The standard approach to the resection of aortic valve papillary fibroelastoma has involved traditional full median sternotomy. "